ORPHA:314769
Somatomammotropinoma
Synonyms: GH and PRL cosecreting pituitary adenoma · Growth hormone and prolactin cosecreting pituitary adenoma · Somatolactotropinoma · Somatoprolactinoma
- Type
- Disease
- Group
- Disorder
- Age of onset
- Adolescent, Adult
- Status
- active
A rare, mixed, functioning pituitary adenoma characterized by the cosecretion of growth hormone and prolactin, which manifests with signs and symptoms of both acromegaly and hyperprolactinemia.
1
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Somatomammotropinoma | GH and PRL cosecreting pituitary adenoma · Growth hormone and prolactin cosecreting pituitary adenoma · Somatolactotropinoma · Somatoprolactinoma |
| fr | Somatomammotropinome | Adénome hypophysaire secrétant GH et PRL · Adénome hypophysaire secrétant l'hormone de croissance et la prolactine · Adénome hypophysaire somatoprolactinique |
| de | Somatomammotropinom | Hypophysenadenom, GH und PRL co-sezernierendes · Wachtumshormon und Prolaktin co-sezernierendes Hypophysenadenom |
| es | Somatomamotropinoma | Adenoma hipofisario co-secretor de GH y PRL · Adenoma hipofisario co-secretor de hormona de crecimiento y prolactina · Somatolactotropinoma · Somatoprolactinoma |
| it | Somatomammotropinoma | Adenoma ipofisario co-secernente GH e PRL · Adenoma ipofisario co-secernente l'ormone della crescita e la prolattina |
| nl | Somatomammotropinoom | Somatolactotropinoom · Somatoprolactinoom · GH- en PRL-co-afscheidend hypofyseadenoom · Groeihormoon- en prolactine-co-afscheidend hypofyseadenoom |
| pt | Somatomamotropinoma | Adenoma pituitário co-secretor de GH e PRL · Adenoma pituitário co-secretor de hormona de crescimento e prolactina |
| pl | Somatomammotropinoma | Gruczolak przysadki wydzielający GH i PRL · Gruczolak przysadki wydzielający hormon wzrostu i prolaktynę |
| cs | Mammo-somatotrofní adenom | Adenom hypofýzy produkující GH a PRL · Adenom hypofýzy produkující růstový hormon a prolaktin |
| uk | Соматомаммотропінома | Аденома гіпофіза, що косекретує ГР та ПРЛ · Аденома гіпофіза, що косекретує гормон росту та пролактин · Соматолактотропінома · Соматопролактинома |
| zh | 体细胞生长激素瘤 | 生长激素和泌乳素共分泌性垂体腺瘤 |
| tr | Somatomamotropinom | Somatoprolaktinom · Somatolaktotropinom · GH ve PRL salgılayan hipofiz adenomu · Büyüme hormonu ve prolaktin salgılayan hipofiz adenomu |
Definition in:
2
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | D35.2 | NTBT | attributed | validated |
| ICD-11 | 2F37.Y | NTBT | attributed | validated |
| MONDO | 0017823 | E | validated | |
| UMLS | C4755297 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
3
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (2):
- ORPHA:715120Hyperpituitarism
rare endocrine diseases - ORPHA:314759Mixed functioning pituitary adenoma
rare endocrine diseases; rare neoplastic diseases
No children.
4
Genes
0 directOrphanet records no gene directly on this code.
5
Prevalence and incidence
1 record| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Point prevalence | Unknown | — | Worldwide | Class only | Validated | ORPHANET |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
6
HPO phenotypes
60 annotations · validated 2019-02-25| HPO | Term (as annotated by Orphanet) | Diagnostic |
|---|---|---|
| Very frequent (99-80%) | ||
| HP:0000830 | Anterior hypopituitarism | |
| HP:0002829 | Arthralgia | |
| HP:0001769 | Broad foot | |
| HP:0000337 | Broad forehead | |
| HP:0000280 | Coarse facial features | |
| HP:0003859 | Cortical diaphyseal thickening of the upper limbs | |
| HP:0006191 | Deep palmar crease | |
| HP:0001869 | Deep plantar creases | |
| HP:0000845 | Elevated circulating growth hormone concentration | Diagnostic criterion |
| HP:0012378 | Fatigue | |
| HP:0000293 | Full cheeks | |
| HP:0000975 | Hyperhidrosis | |
| HP:0000870 | Increased circulating prolactin concentration | Diagnostic criterion |
| HP:0001386 | Joint swelling | |
| HP:0001176 | Large hands | |
| HP:0000276 | Long face | |
| HP:0004099 | Macrodactyly | |
| HP:0000158 | Macroglossia | |
| HP:0000400 | Macrotia | |
| HP:0000303 | Mandibular prognathia | |
| HP:0002758 | Osteoarthritis | |
| HP:0000098 | Tall stature | |
| HP:0001182 | Tapered finger | |
| HP:0000179 | Thick lower lip vermilion | |
| HP:0001072 | Thickened skin | |
| HP:0000445 | Wide nose | |
| Frequent (79-30%) | ||
| HP:0001231 | Abnormal fingernail morphology | |
| HP:0008388 | Abnormal toenail morphology | |
| HP:0000164 | Abnormality of the dentition | |
| HP:0000141 | Amenorrhea | |
| HP:0000739 | Anxiety | |
| HP:0012802 | Broad jaw | |
| HP:0100021 | Cerebral palsy | |
| HP:0000716 | Depression | |
| HP:0000819 | Diabetes mellitus | |
| HP:0100607 | Dysmenorrhea | |
| HP:0002007 | Frontal bossing | |
| HP:0100829 | Galactorrhea | |
| HP:0002230 | Generalized hirsutism | |
| HP:0001609 | Hoarse voice | |
| HP:0000822 | Hypertension | |
| HP:0000044 | Hypogonadotropic hypogonadism | |
| HP:0002808 | Kyphosis | |
| HP:0002076 | Migraine | |
| HP:0100540 | Palpebral edema | |
| HP:0003401 | Paresthesia | |
| HP:0002893 | Pituitary adenoma | |
| HP:0011760 | Pituitary growth hormone cell adenoma | Diagnostic criterion |
| HP:0006767 | Pituitary prolactin cell adenoma | Diagnostic criterion |
| HP:0010535 | Sleep apnea | |
| HP:0003416 | Spinal canal stenosis | |
| HP:0000664 | Synophrys | |
| HP:0000687 | Widely spaced teeth | |
| Occasional (29-5%) | ||
| HP:0000956 | Acanthosis nigricans | |
| HP:0100518 | Dysuria | |
| HP:0007440 | Generalized hyperpigmentation | |
| HP:0100786 | Hypersomnia | |
| HP:0001639 | Hypertrophic cardiomyopathy | |
| HP:0000802 | Impotence | |
| HP:0001653 | Mitral regurgitation | |
Run the differential on the 12 obligate / very frequent terms
Annotation source: 22720333[PMID]
7
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/314769
- This record as JSON: /data/d/314769.json