{"orpha":314769,"name":"Somatomammotropinoma","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":["GH and PRL cosecreting pituitary adenoma","Growth hormone and prolactin cosecreting pituitary adenoma","Somatolactotropinoma","Somatoprolactinoma"],"definition":"A rare, mixed, functioning pituitary adenoma characterized by the cosecretion of growth hormone and prolactin, which manifests with signs and symptoms of both acromegaly and hyperprolactinemia.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-314769/","orphanet_url":"https://www.orpha.net/en/disease/detail/314769","names":{"fr":{"name":"Somatomammotropinome","synonyms":["Adénome hypophysaire secrétant GH et PRL","Adénome hypophysaire secrétant l'hormone de croissance et la prolactine","Adénome hypophysaire somatoprolactinique"],"definition":"Adénome hypophysaire fonctionnel mixte rare caractérisé par une sécrétion simultanée d'hormone de croissance et de prolactine, se manifestant par des signes et des symptômes d'acromégalie et d'hyperprolactinémie."},"de":{"name":"Somatomammotropinom","synonyms":["Hypophysenadenom, GH und PRL co-sezernierendes","Wachtumshormon und Prolaktin co-sezernierendes Hypophysenadenom"]},"es":{"name":"Somatomamotropinoma","synonyms":["Adenoma hipofisario co-secretor de GH y PRL","Adenoma hipofisario co-secretor de hormona de crecimiento y prolactina","Somatolactotropinoma","Somatoprolactinoma"],"definition":"El somatomamotropinoma es un adenoma hipofisario funcionante, mixto y poco frecuente, caracterizado por la co-secreción de hormona del crecimiento y prolactina, que se manifiesta con signos y síntomas de ambos, acromegalia e hiperprolactinemia."},"it":{"name":"Somatomammotropinoma","synonyms":["Adenoma ipofisario co-secernente GH e PRL","Adenoma ipofisario co-secernente l'ormone della crescita e la prolattina"],"definition":"Il somatomammotropinoma è un adenoma ipofisario misto funzionante raro, che secerne contemporaneamente l'ormone della crescita e la prolattina. I pazienti presentano i segni clinici caratteristici dell'acromegalia e dell'iperprolattinemia."},"nl":{"name":"Somatomammotropinoom","synonyms":["Somatolactotropinoom","Somatoprolactinoom","GH- en PRL-co-afscheidend hypofyseadenoom","Groeihormoon- en prolactine-co-afscheidend hypofyseadenoom"],"definition":"Somatomammotropinoom is een zeldzaam, gemengd, functionerend hypofyseadenoom, en wordt gekarakteriseerd door co-secretie van groeihormoon en prolactine, dat zich manifesteert met tekenen en symptomen van zowel acromegalie als hyperprolactinemie."},"pt":{"name":"Somatomamotropinoma","synonyms":["Adenoma pituitário co-secretor de GH e PRL","Adenoma pituitário co-secretor de hormona de crescimento e prolactina"]},"pl":{"name":"Somatomammotropinoma","synonyms":["Gruczolak przysadki wydzielający GH i PRL","Gruczolak przysadki wydzielający hormon wzrostu i prolaktynę"],"definition":"*Somatomammotropinoma/Gruczolak przysadki wydzielający hormon wzrostu i prolaktynę jest rzadkim, mieszanym, hormonalnie czynnym gruczolakiem przysadki, który charakteryzuje się jednoczesnym wydzielaniem hormonu wzrostu i prolaktyny, co daje podmiotowe i przedmiotowe objawy akromegalii i hiperprolaktynemii."},"cs":{"name":"Mammo-somatotrofní adenom","synonyms":["Adenom hypofýzy produkující GH a PRL","Adenom hypofýzy produkující růstový hormon a prolaktin"]},"uk":{"name":"Соматомаммотропінома","synonyms":["Аденома гіпофіза, що косекретує ГР та ПРЛ","Аденома гіпофіза, що косекретує гормон росту та пролактин","Соматолактотропінома","Соматопролактинома"],"definition":"A rare, mixed, functioning pituitary adenoma characterized by the cosecretion of growth hormone and prolactin, which manifests with signs and symptoms of both acromegaly and hyperprolactinemia."},"zh":{"name":"体细胞生长激素瘤","synonyms":["生长激素和泌乳素共分泌性垂体腺瘤"],"definition":"生长激素瘤是一种罕见的混合性功能性垂体腺瘤，以生长激素和催乳素的共同分泌为特征，表现为肢端肥大症和高催乳素血症。"},"tr":{"name":"Somatomamotropinom","synonyms":["Somatoprolaktinom","Somatolaktotropinom","GH ve PRL salgılayan hipofiz adenomu","Büyüme hormonu ve prolaktin salgılayan hipofiz adenomu"]}},"xrefs":[{"source":"ICD-10","code":"D35.2","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"ICD-11","code":"2F37.Y","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"MONDO","code":"0017823","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C4755297","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":97978,"name":"Rare endocrine disease"},"parents":[{"orpha":715120,"name":"Hyperpituitarism","classifications":[193]},{"orpha":314759,"name":"Mixed functioning pituitary adenoma","classifications":[193,202]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":[],"onset":["Adolescent","Adult"],"prevalence":[{"type":"Point prevalence","qualification":"Class only","class":"Unknown","value":0.0,"area":"Worldwide","status":"Validated","source":"ORPHANET"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2019-02-25","source":"22720333[PMID]","terms":[{"hpo":"HP:0000830","label":"Anterior hypopituitarism","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0002829","label":"Arthralgia","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0001769","label":"Broad foot","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0000337","label":"Broad forehead","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0000280","label":"Coarse facial features","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0003859","label":"Cortical diaphyseal thickening of the upper limbs","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0006191","label":"Deep palmar crease","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0001869","label":"Deep plantar creases","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0000845","label":"Elevated circulating growth hormone concentration","frequency":"Very frequent (99-80%)","criteria":"Diagnostic criterion"},{"hpo":"HP:0012378","label":"Fatigue","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0000293","label":"Full cheeks","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0000975","label":"Hyperhidrosis","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0000870","label":"Increased circulating prolactin concentration","frequency":"Very frequent (99-80%)","criteria":"Diagnostic criterion"},{"hpo":"HP:0001386","label":"Joint swelling","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0001176","label":"Large hands","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0000276","label":"Long face","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0004099","label":"Macrodactyly","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0000158","label":"Macroglossia","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0000400","label":"Macrotia","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0000303","label":"Mandibular prognathia","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0002758","label":"Osteoarthritis","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0000098","label":"Tall stature","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0001182","label":"Tapered finger","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0000179","label":"Thick lower lip vermilion","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0001072","label":"Thickened skin","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0000445","label":"Wide nose","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0001231","label":"Abnormal fingernail morphology","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0008388","label":"Abnormal toenail morphology","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000164","label":"Abnormality of the dentition","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000141","label":"Amenorrhea","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000739","label":"Anxiety","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0012802","label":"Broad jaw","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0100021","label":"Cerebral palsy","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000716","label":"Depression","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000819","label":"Diabetes mellitus","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0100607","label":"Dysmenorrhea","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002007","label":"Frontal bossing","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0100829","label":"Galactorrhea","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002230","label":"Generalized hirsutism","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001609","label":"Hoarse voice","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000822","label":"Hypertension","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000044","label":"Hypogonadotropic hypogonadism","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002808","label":"Kyphosis","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002076","label":"Migraine","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0100540","label":"Palpebral edema","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0003401","label":"Paresthesia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002893","label":"Pituitary adenoma","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0011760","label":"Pituitary growth hormone cell adenoma","frequency":"Frequent (79-30%)","criteria":"Diagnostic criterion"},{"hpo":"HP:0006767","label":"Pituitary prolactin cell adenoma","frequency":"Frequent (79-30%)","criteria":"Diagnostic criterion"},{"hpo":"HP:0010535","label":"Sleep apnea","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0003416","label":"Spinal canal stenosis","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000664","label":"Synophrys","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000687","label":"Widely spaced teeth","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000956","label":"Acanthosis nigricans","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0100518","label":"Dysuria","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0007440","label":"Generalized hyperpigmentation","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0100786","label":"Hypersomnia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001639","label":"Hypertrophic cardiomyopathy","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000802","label":"Impotence","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001653","label":"Mitral regurgitation","frequency":"Occasional (29-5%)","criteria":null}]}}