Growing teratoma syndrome
- Type
- Particular clinical situation in a disease or syndrome
- Group
- Disorder
- Inheritance
- Not applicable
- Age of onset
- Adult
- Status
- active
A rare neoplastic disorder characterized by benign metastatic masses increasing in size and number after chemotherapy for non-seminomatous germ cell tumors of testis or ovary. It may present at any time after chemotherapy, with a median occurrence within 24 months after treatment completion. Per definition, the resected specimen exclusively contains mature teratoma components, and serum tumor markers have normalized. The retroperitoneum is the most common site, although almost any other localization has been reported. Increased tumor size may cause mechanical compression of vital organs, with renal dysfunction, bowel ischemia, and biliary obstruction as major complications.
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Growing teratoma syndrome | |
| fr | Syndrome du tératome croissant | |
| de | Growing-Teratoma-Syndrom | GTS · Wachsendes Teratom-Syndrom |
| es | Síndrome del teratoma creciente | |
| it | Sindrome del teratoma crescente | |
| nl | Groeiend teratoom-syndroom | |
| pt | Síndrome do tetaroma crescente | |
| pl | Zespół rosnącego potworniaka | |
| cs | Syndrom rostoucího teratomu | |
| uk | Синдром зростаючої тератоми | |
| zh | 生长性畸胎瘤综合征 | |
| tr | Büyüyen teratom sendromu |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | D48.7 | NTBT | attributed | validated |
| MONDO | 0017807 | E | validated | |
| UMLS | C3891714 | E | validated | |
| MedDRA | 10085759 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (1):
- ORPHA:99913Extragonadal non-dysgerminomatous germ cell tumor
rare neoplastic diseases; rare transplant-related disorders
No children.
Genes
0 directOrphanet records no gene directly on this code.
Prevalence and incidence
1 record| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Point prevalence | Unknown | — | Worldwide | Class only | Not yet validated | ORPHANET |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
HPO phenotypes
Orphanet has no HPO annotation for this code in this release.
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/314613
- This record as JSON: /data/d/314613.json