raremaprare-disease reference indexOrphadata 2026-06-23 · HPO 2026-09-01
ORPHA:3096

Reye syndrome

Type
Disease
Group
Disorder
Age of onset
Adolescent, Adult, Childhood, Infancy
Status
active

A rare, systemic disease characterized by persistent vomiting with confusion, lethargy, disorientation, hyperreflexia, hyperventilation, and tachycardia, with rapid progression to seizures, non-inflammatory encephalopathy, coma and death. It typically develops between 12 hours and 3 weeks after recovery from a viral illness, such as upper respiratory tract infection or gastroenteritis. Hepatomegaly, acute hepatic steatosis, fatty liver degeneration and multiple laboratory abnormalities are associated.

1

Names in Orphadata languages

12 of 12 languages
LangNameSynonyms
enReye syndrome
frSyndrome de Reye
deReye-SyndromReye-Sequenz
esSíndrome de Reye
itSindrome di Reye
nlSyndroom van Reye
ptSíndrome Reye
plZespół Reye'a
csReyeův syndromReyův syndrom
ukСиндром Рейє
zhReye综合征
trReye sendromu

Definition in:

2

Cross-references

qualifier = Orphanet mapping relation
SourceCodeQualifierICD relationValidation
ICD-10G93.7NTBTattributedvalidated
ICD-118E46Especificvalidated
MONDO0005942Evalidated
MeSHD012202Evalidated
UMLSC0035400Evalidated
GARD7570Evalidated
MedDRA10039012Evalidated

E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.

3

Classification

Preferential parent (Orphanet linearisation):

Parents in the classifications (1):

No children.

4

Genes

0 direct

Orphanet records no gene directly on this code.

5

Prevalence and incidence

0 records

No prevalence record in this release.

6

HPO phenotypes

Orphanet has no HPO annotation for this code in this release.

7

Sources for this card