{"orpha":3096,"name":"Reye syndrome","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":[],"definition":"A rare, systemic disease characterized by persistent vomiting with confusion, lethargy, disorientation, hyperreflexia, hyperventilation, and tachycardia, with rapid progression to seizures, non-inflammatory encephalopathy, coma and death. It typically develops between 12 hours and 3 weeks after recovery from a viral illness, such as upper respiratory tract infection or gastroenteritis. Hepatomegaly, acute hepatic steatosis, fatty liver degeneration and multiple laboratory abnormalities are associated.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-3096/","orphanet_url":"https://www.orpha.net/en/disease/detail/3096","names":{"fr":{"name":"Syndrome de Reye","definition":"Maladie systémique rare caractérisée par des vomissements persistants accompagnés d'une confusion, d'une léthargie, d'une désorientation, d'une hyperréflexie, d'une hyperventilation et d'une tachycardie, progressant rapidement vers des convulsions, une encéphalopathie non inflammatoire, un coma et le décès. Le syndrome se développe généralement entre 12 heures et 3 semaines après le rétablissement d'une maladie virale, telle qu'une infection des voies respiratoires supérieures ou une gastro-entérite. Une hépatomégalie, une stéatose hépatique aiguë résultant d'une dégénérescence graisseuse du foie, et de multiples anomalies biologiques sont associées."},"de":{"name":"Reye-Syndrom","synonyms":["Reye-Sequenz"],"definition":"Eine seltene, systemische Erkrankung, die durch anhaltendes Erbrechen mit Verwirrung, Lethargie, Desorientierung, Hyperreflexie, Hyperventilation und Tachykardie gekennzeichnet ist und schnell zu Krampfanfällen, nicht-entzündlicher Enzephalopathie, Koma und Tod führt. Sie entwickelt sich typischerweise zwischen 12 Stunden und 3 Wochen nach der Genesung von einer Viruserkrankung, wie einer Infektion der oberen Atemwege oder einer Gastroenteritis. Hepatomegalie, akute Lebersteatose, Fettleberdegeneration und zahlreiche Laboranomalien sind damit verbunden."},"es":{"name":"Síndrome de Reye","definition":"Es una enfermedad sistémica poco frecuente caracterizada por vómitos persistentes que se presentan junto a confusión, letargia, desorientación, hiperreflexia, hiperventilación y taquicardia, con rápida progresión a convulsiones y encefalopatía no inflamatoria que evoluciona a coma y fallecimiento. Por lo general, se desarrolla entre las 12 horas y 3 semanas después de la recuperación de una enfermedad viral, como infecciones del tracto respiratorio superior o gastroenteritis. El síndrome está asociado a hepatomegalia, esteatosis hepática aguda, degeneración del hígado graso y múltiples alteraciones en las determinaciones analíticas."},"it":{"name":"Sindrome di Reye","definition":"È una malattia sistemica rara, caratterizzata da vomito persistente associato a confusione, letargia, disorientamento, iperreflessia, iperventilazione e tachicardia, a rapida evoluzione nelle crisi epilettiche, nell'encefalopatia non infiammatoria, nel coma e nella morte. Di solito esordisce tra dodici ore e tre settimane dopo la guarigione da una malattia virale, ad esempio un'infezione delle vie aeree superiori o una gastroenterite. Si associa ad epatomegalia, steatosi epatica acuta e degenerazione grassa del fegato con anomalie laboratoristiche multiple."},"nl":{"name":"Syndroom van Reye","definition":"Een zeldzame, systemische ziekte gekarakteriseerd door persisterend braken met verwardheid, lethargie, desoriëntatie, hyperreflexie, hyperventilatie, en tachycardie, met snelle progressie naar insulten, niet-inflammatoire encefalopathie, coma en overlijden. Doorgaans ontwikkelt het zich tussen 12 uur en 3 weken na herstel van een virale ziekte, zoals infectie van de bovenste luchtwegen of gastro-enteritis. Hepatomegalie, acute steatose van de lever, degeneratie van vette lever en meervoudige laboratoriumafwijkingen zijn geassocieerd."},"pt":{"name":"Síndrome Reye"},"pl":{"name":"Zespół Reye'a"},"cs":{"name":"Reyeův syndrom","synonyms":["Reyův syndrom"]},"uk":{"name":"Синдром Рейє","definition":"A rare, systemic disease characterized by persistent vomiting with confusion, lethargy, disorientation, hyperreflexia, hyperventilation, and tachycardia, with rapid progression to seizures, non-inflammatory encephalopathy, coma and death. It typically develops between 12 hours and 3 weeks after recovery from a viral illness, such as upper respiratory tract infection or gastroenteritis. Hepatomegaly, acute hepatic steatosis, fatty liver degeneration and multiple laboratory abnormalities are associated."},"zh":{"name":"Reye综合征"},"tr":{"name":"Reye sendromu"}},"xrefs":[{"source":"ICD-10","code":"G93.7","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"ICD-11","code":"8E46","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"649014905"},{"source":"MONDO","code":"0005942","qualifier":"E","icd_relation":null,"validated":true},{"source":"MeSH","code":"D012202","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0035400","qualifier":"E","icd_relation":null,"validated":true},{"source":"GARD","code":"7570","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10039012","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":98006,"name":"Rare neurologic disease"},"parents":[{"orpha":182222,"name":"Rare systemic disease","classifications":[196]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":[],"onset":["Adolescent","Adult","Childhood","Infancy"],"prevalence":[],"phenotypes":null}