ORPHA:300895
ALK-positive anaplastic large cell lymphoma
Synonyms: ALK+ ALCL · ALK+ anaplastic large cell lymphoma
- Type
- Histopathological subtype
- Group
- Subtype of disorder
- Inheritance
- Not applicable
- Age of onset
- Adolescent, Adult, Childhood
- Status
- active
A type of ALCL, a rare and aggressive peripheral T-cell non-Hodgkin lymphoma affecting lymph nodes and extranodal sites, which is characterized by the expression of a protein called anaplastic lymphoma kinase (ALK).
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Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | ALK-positive anaplastic large cell lymphoma | ALK+ ALCL · ALK+ anaplastic large cell lymphoma |
| fr | Lymphome anaplasique à grandes cellules ALK positif | ALCL ALK+ · LAGC ALK+ · Lymphome anaplasique à grandes cellules ALK+ |
| de | Lymphom, anaplastisches großzelliges, ALK-positives | ALK+ ALCL · ALK+ anaplastisches großzelliges Lymphom |
| es | Linfoma anaplásico de células grandes ALK-positivo | ALK+ ALCL · Linfoma anaplásico de células grandes ALK+ |
| it | Linfoma anaplastico a grandi cellule ALK-positivo | ALK+ ALCL · Linfoma anaplastico a grandi cellule ALK+ |
| nl | ALK-positief anaplastisch grootcellig lymfoom | ALK+ ALCL · ALK+ anaplastisch grootcellig lymfoom |
| pt | Linfoma anaplásico de grandes células ALK - positivo | |
| pl | ALK-pozytywny chłoniak anaplastyczny z dużych komórek | ALK+ ALCL · ALK+ chłoniak anaplastyczny z dużych komórek |
| cs | ALK-pozitivní anaplastický velkobuněčný lymfom | ALK+ ALCL · ALK+ anaplastický velkobuněčný lymfom |
| uk | ALK-позитивна анапластична великоклітинна лімфома | ALK+ ALCL · Анапластична великоклітинна лімфома ALK+ |
| zh | ALK阳性间变性大细胞淋巴瘤 | ALK阳性间变性大细胞淋巴瘤 |
| tr | ALK-pozitif anaplastik büyük hücreli lenfoma | ALK+ ALCL · ALK + anaplastik büyük hücreli lenfoma |
Definition in:
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Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | C84.6 | E | specific | validated |
| ICD-11 | 2A90.A | E | specific | validated |
| ICD-11 | XH9484 | E | specific | validated |
| MONDO | 0017602 | E | validated | |
| UMLS | C1332079 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
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Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (1):
- ORPHA:98841Anaplastic large cell lymphoma
rare hematological diseases; rare neoplastic diseases; rare transplant-related disorders
No children.
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Genes
1 direct| Gene | Association | Status | HGNC | Ensembl | OMIM | Locus | Name | Source of validation |
|---|---|---|---|---|---|---|---|---|
| ALK | Disease-causing somatic mutation(s) in | Assessed | HGNC:427 | ENSG00000171094 | 105590 | 2p23.2-p23.1 | ALK receptor tyrosine kinase | 12112524[PMID] |
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Prevalence and incidence
1 record| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Point prevalence | Unknown | — | Europe | Class only | Not yet validated | ORPHANET |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
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HPO phenotypes
Orphanet has no HPO annotation for this code in this release.
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Sources for this card
- Orphanet page: orpha.net/en/disease/detail/300895
- This record as JSON: /data/d/300895.json