{"orpha":300895,"name":"ALK-positive anaplastic large cell lymphoma","type":"Histopathological subtype","group":"Subtype of disorder","status":"active","flags":[],"synonyms":["ALK+ ALCL","ALK+ anaplastic large cell lymphoma"],"definition":"A type of ALCL, a rare and aggressive peripheral T-cell non-Hodgkin lymphoma affecting lymph nodes and extranodal sites, which is characterized by the expression of a protein called anaplastic lymphoma kinase (ALK).","note":null,"url":"https://raremap.alftech.space/d/ORPHA-300895/","orphanet_url":"https://www.orpha.net/en/disease/detail/300895","names":{"fr":{"name":"Lymphome anaplasique à grandes cellules ALK positif","synonyms":["ALCL ALK+","LAGC ALK+","Lymphome anaplasique à grandes cellules ALK+"],"definition":"Le lymphome anaplasique à grandes cellules ALK positif (LAGC ALK+) est un type de LAGC, un lymphome non hodgkinien à cellules T périphériques, agressif et rare, qui affecte les ganglions lymphatiques et des sites extra-nodaux. Il est caractérisé par l'expression de la protéine kinase lymphome anaplasique (ALK)."},"de":{"name":"Lymphom, anaplastisches großzelliges, ALK-positives","synonyms":["ALK+ ALCL","ALK+ anaplastisches großzelliges Lymphom"]},"es":{"name":"Linfoma anaplásico de células grandes ALK-positivo","synonyms":["ALK+ ALCL","Linfoma anaplásico de células grandes ALK+"],"definition":"Es un tipo de linfoma anaplásico de células grandes (LACG), un linfoma periférico no-Hodgkin de células T poco frecuente y agresivo, que afecta a los ganglios linfáticos y regiones extraganglionares, que se caracteriza por la expresión de una proteína llamada quinasa del linfoma anaplásico (ALK, por sus siglas en inglés)."},"it":{"name":"Linfoma anaplastico a grandi cellule ALK-positivo","synonyms":["ALK+ ALCL","Linfoma anaplastico a grandi cellule ALK+"],"definition":"Il linfoma anaplastico a grandi cellule ALK-positivo (ALK+ ALCL) è un tipo di ALCL (si veda questo termine), un linfoma periferico non-Hodgkin a cellule T, raro e aggressivo, che interessa i linfonodi e le sedi extranodali ed è caratterizzato dall'espressione della proteina ALK, chinasi del linfoma anaplastico."},"nl":{"name":"ALK-positief anaplastisch grootcellig lymfoom","synonyms":["ALK+ ALCL","ALK+ anaplastisch grootcellig lymfoom"],"definition":"Een type van ALCL, een zeldzaam en agressief perifeer T-cel non-Hodgkinlymfoom dat lymfeklieren en gebieden buiten de lymfeklieren treft, gekarakteriseerd door de expressie van een proteïne genaamd anaplastisch lymfoomkinase (ALK)."},"pt":{"name":"Linfoma anaplásico de grandes células ALK - positivo"},"pl":{"name":"ALK-pozytywny chłoniak anaplastyczny z dużych komórek","synonyms":["ALK+ ALCL","ALK+ chłoniak anaplastyczny z dużych komórek"]},"cs":{"name":"ALK-pozitivní anaplastický velkobuněčný lymfom","synonyms":["ALK+ ALCL","ALK+ anaplastický velkobuněčný lymfom"]},"uk":{"name":"ALK-позитивна анапластична великоклітинна лімфома","synonyms":["ALK+ ALCL","Анапластична великоклітинна лімфома ALK+"],"definition":"A type of ALCL, a rare and aggressive peripheral T-cell non-Hodgkin lymphoma affecting lymph nodes and extranodal sites, which is characterized by the expression of a protein called anaplastic lymphoma kinase (ALK)."},"zh":{"name":"ALK阳性间变性大细胞淋巴瘤","synonyms":["ALK阳性间变性大细胞淋巴瘤"],"definition":"一种ALCL，罕见的侵袭性外周T细胞非霍奇金淋巴瘤，累及淋巴结和结外部位，其特征为间变性淋巴瘤激酶（ALK）表达。"},"tr":{"name":"ALK-pozitif anaplastik büyük hücreli lenfoma","synonyms":["ALK+ ALCL","ALK + anaplastik büyük hücreli lenfoma"]}},"xrefs":[{"source":"ICD-10","code":"C84.6","qualifier":"E","icd_relation":"specific","validated":true},{"source":"ICD-11","code":"2A90.A","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"589245621"},{"source":"ICD-11","code":"XH9484","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"1797801084"},{"source":"MONDO","code":"0017602","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C1332079","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":250908,"name":"Rare neoplastic disease"},"parents":[{"orpha":98841,"name":"Anaplastic large cell lymphoma","classifications":[194,202,233]}],"children":[],"genes":[{"symbol":"ALK","name":"ALK receptor tyrosine kinase","gene_type":"gene with protein product","association":"Disease-causing somatic mutation(s) in","status":"Assessed","source":"12112524[PMID]","hgnc":"427","ensembl":"ENSG00000171094","omim":"105590","loci":["2p23.2-p23.1"]}],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["Adolescent","Adult","Childhood"],"prevalence":[{"type":"Point prevalence","qualification":"Class only","class":"Unknown","value":0.0,"area":"Europe","status":"Not yet validated","source":"ORPHANET"}],"phenotypes":null}