ORPHA:29207
Reactive arthritis
Synonyms: Fiessinger-Leroy disease
- Type
- Disease
- Group
- Disorder
- Inheritance
- Multigenic/multifactorial, Not applicable
- Age of onset
- Adolescent, Adult, Elderly
- Status
- active
A rare spondyloarthritis characterized by acute or chronic sterile synovitis with or without extra-articular manifestations, becoming manifest after an infection.
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Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Reactive arthritis | Fiessinger-Leroy disease |
| fr | Arthrite réactionnelle | Maladie de Fiessinger-Leroy |
| de | Arthritis, reaktive | Fiessinger-Leroy-Krankheit |
| es | Artritis reactiva | Enfermedad de Fiessinger-Leroy |
| it | Artrite reattiva | Malattia di Fiessinger-Leroy |
| nl | Reactieve artritis | Ziekte van Fiessinger-Leroy |
| pt | Artrite reativa | Artrite uretrítica · Artrite venérea · Doença de Fiessinger-Leroy · Poliartrite entérica |
| pl | Reaktywne zapalenie stawów | Choroba Fiessingera i Leroy'a · Zespół Fiessingera, Leroy'a i Reitera · Zespół Reitera · Choroba Reitera · Zespół Reitera · Choroba Fiessingera i Leroy'a · Zespół Fiessingera, Leroy'a i Reitera |
| cs | Reaktivní artritida | Arthritis urethritica · Fiessingerova-Leroyova choroba · Polyarteritis enterica · Venerická artritida · Fiessingerův-Leroyův-Reiterův syndrom · Reiterův syndrom · Fiessinger-Leroyova choroba · Fiessinger-Leroy-Reiterův syndrom |
| uk | Реактивний артрит | Артрит уретричний · Хвороба Фіссінгера-Леруа · Кишковий поліартрит · Венеричний артрит |
| zh | 反应性关节炎 | Fiessinger-Leroy-Reiter 综合征 |
| tr | Reaktif artrit | Reiter hastalığı · Reiter sendromu · Zührevi artrit · Artrit üretrit · Poliartrit enterika · Fiessinger-Leroy hastalığı · Fiessinger-Leroy-Reiter sendromu |
Definition in:
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Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | M02.3 | E | specific | validated |
| ICD-11 | FA11.2 | NTBT | specific | validated |
| MONDO | 0017376 | E | validated | |
| MeSH | D016918 | E | validated | |
| UMLS | C0085435 | E | validated | |
| GARD | 5693 | E | validated | |
| MedDRA | 10003267 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
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Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (2):
- ORPHA:486955Rare pediatric rheumatologic disease
rare systemic or rheumatologic diseases of childhood - ORPHA:182231Rare rheumatologic disease
rare systemic and rheumatological diseases
No children.
Codes that Orphanet moved or referred to this one:
- ORPHA:93688OBSOLETE: Non-idiopathic juvenile arthritis referred to · inactive
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Genes
2 direct| Gene | Association | Status | HGNC | Ensembl | OMIM | Locus | Name | Source of validation |
|---|---|---|---|---|---|---|---|---|
| HLA-B | Biomarker tested in | Not yet assessed | HGNC:4932 | ENSG00000234745 | 142830 | 6p21.33 | major histocompatibility complex, class I, B | |
| HLA-B | Major susceptibility factor in | Assessed | HGNC:4932 | ENSG00000234745 | 142830 | 6p21.33 | major histocompatibility complex, class I, B | 33014690[PMID] |
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Prevalence and incidence
1 record| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Point prevalence | 1-9 / 100 000 | — | Worldwide | Class only | Validated | ORPHANET |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
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HPO phenotypes
36 annotations · validated 2024-10-09| HPO | Term (as annotated by Orphanet) | Diagnostic |
|---|---|---|
| Very frequent (99-80%) | ||
| HP:0001597 | Abnormal nail morphology | |
| HP:0002829 | Arthralgia | |
| HP:0001369 | Arthritis | |
| HP:0100773 | Cartilage destruction | |
| HP:0100543 | Cognitive impairment | |
| HP:0000509 | Conjunctivitis | |
| HP:0002014 | Diarrhea | |
| HP:0008391 | Dystrophic fingernails | |
| HP:0100686 | Enthesitis | |
| HP:0000962 | Hyperkeratosis | |
| HP:0001387 | Joint stiffness | |
| HP:0001386 | Joint swelling | |
| HP:0002754 | Osteomyelitis | |
| HP:0200039 | Pustule | |
| HP:0011107 | Recurrent aphthous stomatitis | |
| Frequent (79-30%) | ||
| HP:0002027 | Abdominal pain | |
| HP:0002103 | Abnormality of the pleura | |
| HP:0002037 | Inflammation of the large intestine | |
| HP:0001101 | Iritis | |
| HP:0003419 | Low back pain | |
| HP:0000988 | Skin rash | |
| Occasional (29-5%) | ||
| HP:0001659 | Aortic regurgitation | |
| HP:0034438 | Balanitis | |
| HP:0011227 | Elevated circulating C-reactive protein concentration | |
| HP:0003565 | Elevated erythrocyte sedimentation rate | |
| HP:0012219 | Erythema nodosum | |
| HP:0001945 | Fever | |
| HP:0001701 | Pericarditis | |
| HP:0000613 | Photophobia | |
| HP:0002206 | Pulmonary fibrosis | |
| HP:0000010 | Recurrent urinary tract infections | |
| HP:0002093 | Respiratory insufficiency | |
| HP:0012317 | Sacroiliac arthritis | |
| HP:0500006 | Urethritis | |
| HP:0000554 | Uveitis | |
| HP:0001824 | Weight loss | |
Run the differential on the 12 obligate / very frequent terms
Annotation source: 33014690[PMID]
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Sources for this card
- Orphanet page: orpha.net/en/disease/detail/29207
- This record as JSON: /data/d/29207.json