{"orpha":29207,"name":"Reactive arthritis","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":["Fiessinger-Leroy disease"],"definition":"A rare spondyloarthritis characterized by acute or chronic sterile synovitis with or without extra-articular manifestations, becoming manifest after an infection.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-29207/","orphanet_url":"https://www.orpha.net/en/disease/detail/29207","names":{"fr":{"name":"Arthrite réactionnelle","synonyms":["Maladie de Fiessinger-Leroy"],"definition":"Spondylarthrite rare caractérisée par une synovite aseptique aiguë ou chronique, avec ou sans manifestations extra-articulaires, se déclarant après une infection."},"de":{"name":"Arthritis, reaktive","synonyms":["Fiessinger-Leroy-Krankheit"],"definition":"Eine seltene Spondyloarthritis, die durch eine akute oder chronische sterile Synovitis mit oder ohne extraartikuläre Manifestationen gekennzeichnet ist und sich nach einer Infektion manifestiert."},"es":{"name":"Artritis reactiva","synonyms":["Enfermedad de Fiessinger-Leroy"],"definition":"Es una espondiloartritis poco frecuente caracterizada por sinovitis estéril aguda o crónica, con o sin manifestaciones extra-articulares, que se manifiesta tras una infección."},"it":{"name":"Artrite reattiva","synonyms":["Malattia di Fiessinger-Leroy"],"definition":"Si tratta di una spondiloartrite rara, caratterizzata da sinovite sterile, acuta o cronica, con o senza sintomi extra-articolari, che si manifesta a seguito di un'infezione."},"nl":{"name":"Reactieve artritis","synonyms":["Ziekte van Fiessinger-Leroy"],"definition":"Een zeldzame spondyloartritis, gekenmerkt door acute of chronische steriele synovitis met of zonder extra-articulaire manifestaties, die zich manifesteert na een infectie."},"pt":{"name":"Artrite reativa","synonyms":["Artrite uretrítica","Artrite venérea","Doença de Fiessinger-Leroy","Poliartrite entérica"],"definition":"Espondiloartrite rara caracterizada por sinuvite crónica estéril com/sem manifestações extra-articulares, que surgem após episódio infecioso."},"pl":{"name":"Reaktywne zapalenie stawów","synonyms":["Choroba Fiessingera i Leroy'a","Zespół Fiessingera, Leroy'a i Reitera","Zespół Reitera","Choroba Reitera","Zespół Reitera","Choroba Fiessingera i Leroy'a","Zespół Fiessingera, Leroy'a i Reitera"]},"cs":{"name":"Reaktivní artritida","synonyms":["Arthritis urethritica","Fiessingerova-Leroyova choroba","Polyarteritis enterica","Venerická artritida","Fiessingerův-Leroyův-Reiterův syndrom","Reiterův syndrom","Fiessinger-Leroyova choroba","Fiessinger-Leroy-Reiterův syndrom"]},"uk":{"name":"Реактивний артрит","synonyms":["Артрит уретричний","Хвороба Фіссінгера-Леруа","Кишковий поліартрит","Венеричний артрит"],"definition":"A rare spondyloarthritis characterized by acute or chronic sterile synovitis with or without extra-articular manifestations, becoming manifest after an infection."},"zh":{"name":"反应性关节炎","synonyms":["Fiessinger-Leroy-Reiter 综合征"]},"tr":{"name":"Reaktif artrit","synonyms":["Reiter hastalığı","Reiter sendromu","Zührevi artrit","Artrit üretrit","Poliartrit enterika","Fiessinger-Leroy hastalığı","Fiessinger-Leroy-Reiter sendromu"]}},"xrefs":[{"source":"ICD-10","code":"M02.3","qualifier":"E","icd_relation":"specific","validated":true},{"source":"ICD-11","code":"FA11.2","qualifier":"NTBT","icd_relation":"specific","validated":true,"icd11_uri":"594689864"},{"source":"MONDO","code":"0017376","qualifier":"E","icd_relation":null,"validated":true},{"source":"MeSH","code":"D016918","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0085435","qualifier":"E","icd_relation":null,"validated":true},{"source":"GARD","code":"5693","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10003267","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[{"type":"Referred to","orpha":93688,"name":"OBSOLETE: Non-idiopathic juvenile arthritis","status":"inactive"}],"preferential_parent":{"orpha":98023,"name":"Rare systemic or rheumatologic disease"},"parents":[{"orpha":486955,"name":"Rare pediatric rheumatologic disease","classifications":[231]},{"orpha":182231,"name":"Rare rheumatologic disease","classifications":[196]}],"children":[],"genes":[{"symbol":"HLA-B","name":"major histocompatibility complex, class I, B","gene_type":"gene with protein product","association":"Biomarker tested in","status":"Not yet assessed","source":null,"hgnc":"4932","ensembl":"ENSG00000234745","omim":"142830","loci":["6p21.33"]},{"symbol":"HLA-B","name":"major histocompatibility complex, class I, B","gene_type":"gene with protein product","association":"Major susceptibility factor in","status":"Assessed","source":"33014690[PMID]","hgnc":"4932","ensembl":"ENSG00000234745","omim":"142830","loci":["6p21.33"]}],"genes_via_subtypes":[],"inheritance":["Multigenic/multifactorial","Not applicable"],"onset":["Adolescent","Adult","Elderly"],"prevalence":[{"type":"Point prevalence","qualification":"Class only","class":"1-9 / 100 000","value":0.0,"area":"Worldwide","status":"Validated","source":"ORPHANET"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2024-10-09","source":"33014690[PMID]","terms":[{"hpo":"HP:0001597","label":"Abnormal nail morphology","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0002829","label":"Arthralgia","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0001369","label":"Arthritis","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0100773","label":"Cartilage destruction","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0100543","label":"Cognitive impairment","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0000509","label":"Conjunctivitis","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0002014","label":"Diarrhea","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0008391","label":"Dystrophic fingernails","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0100686","label":"Enthesitis","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0000962","label":"Hyperkeratosis","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0001387","label":"Joint stiffness","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0001386","label":"Joint swelling","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0002754","label":"Osteomyelitis","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0200039","label":"Pustule","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0011107","label":"Recurrent aphthous stomatitis","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0002027","label":"Abdominal pain","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002103","label":"Abnormality of the pleura","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002037","label":"Inflammation of the large intestine","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001101","label":"Iritis","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0003419","label":"Low back pain","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000988","label":"Skin rash","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001659","label":"Aortic regurgitation","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0034438","label":"Balanitis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0011227","label":"Elevated circulating C-reactive protein concentration","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0003565","label":"Elevated erythrocyte sedimentation rate","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0012219","label":"Erythema nodosum","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001945","label":"Fever","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001701","label":"Pericarditis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000613","label":"Photophobia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002206","label":"Pulmonary fibrosis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000010","label":"Recurrent urinary tract infections","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002093","label":"Respiratory insufficiency","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0012317","label":"Sacroiliac arthritis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0500006","label":"Urethritis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000554","label":"Uveitis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001824","label":"Weight loss","frequency":"Occasional (29-5%)","criteria":null}]}}