Tropical spastic paraparesis
Synonyms: HAM/TSP · HTLV-1-associated myelopathy/tropical spastic paraparesis · Human T-lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis · Human T-lymphotropic virus type-1-associated myelopathy/tropical spastic paraparesis · TSP
- Type
- Disease
- Group
- Disorder
- Inheritance
- Not applicable
- Age of onset
- Adult
- Status
- active
Tropical spastic paraparesis is a chronic systemic immune-mediated inflammatory myeloneuropathy, more frequently reported in women than in men, that usually presents in adulthood with slowly progressive spastic paraparesis of the lower limbs, bladder and bowel dysfunction, and sensory disturbances in the lower extremities (e.g. paresthesia and dysesthesia) and that is associated with a human T-cell lymphotropic virus type 1 (HTLV-1) infection.
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Tropical spastic paraparesis | HAM/TSP · HTLV-1-associated myelopathy/tropical spastic paraparesis · Human T-lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis · Human T-lymphotropic virus type-1-associated myelopathy/tropical spastic paraparesis · TSP |
| fr | Paraparésie spastique tropicale | HAM/TSP · Myélopathie associée au HTLV-1 · Paraparésie spastique tropicale associée au HTLV1 · Paraparésie spastique tropicale associée au virus T-lymphotrope humain de type 1 · Paraparésie spastique tropicale associée au virus T-lymphotrope humain de type I · TSP |
| de | Tropische Spastische Paraparese | HAM/TSP · HTLV-1-assoziierte Myelopathie · Humane T-lymphotrope Virus 1-assoziierte Myelopathie/Tropische Spastische Paraparese · TSP |
| es | Paraparesia espástica tropical | HAM/TSP · Paraparesia espástica tropical/mielopatía asociada al HTLV-1 · Paraparesia espástica tropical/mielopatía asociada al virus linfotrópico de células T humanas tipo 1 · Paraparesia espástica tropical/mielopatía asociada al virus linfotrópico de células T humanas tipo I · TSP |
| it | Paraparesi spastica tropicale | HAM/TSP · Mielopatia/paraparesi spastica tropicale, associata a HTLV-1 · Mielopatia/paraparesi spastica tropicale, associata a virus T-linfotropico umano tipo 1 · Mielopatia/paraparesi spastica tropicale, associata a virus T-linfotropico umano tipo I · TSP |
| nl | Tropische spastische paraparese | HAM/TSP · HTLV-1-geassocieerde myelopathie/tropische spastische paraparese · Humaan T-lymfotroop virus type 1-geassocieerde myelopathie/tropische spastische paraparese · Humaan T-lymfotroop virus type I-geassocieerde myelopathie/tropische spastische paraparese · TSP |
| pt | Paraparésia espástica tropical | HAM/TSP · Mielopatia associada ao HTLV-1/paraparésia espástica tropical · Mielopatia associada ao vírus linfotrópico-T humano tipo 1/paraparésia espástica tropical · Mielopatia associada ao vírus linfotrópico-T humano tipo I/paraparésia espástica tropical · TSP |
| pl | Tropikalna parapareza spastyczna | HAM/TSP · Mielopatia/tropikalna parapareza spastyczna związana z HTLV-1 · Mielopatia/tropikalna parapareza spastyczna związana z ludzkim wirusem T-limfotropowym typu 1 · Mielopatia/tropikalna parapareza spastyczna związana z ludzkim wirusem T-limfotropowym typu I · TSP |
| cs | Tropická spastická paraparéza | HAM/TSP · Myelopatie/tropická spastická paraparéza asociovaná s HTLV-1 · Myelopatie/tropická spastická paraparéza asociovaná s lidským T-lymfotropickým virem typu I · Myelopatie/tropická spastická paraparéza asociovaná s lidským T-lymfotropickým virem typu 1 · TSP |
| uk | Тропічний спастичний парапарез | HAM/TSP · HTLV-1-асоційована мієлопатія/тропічний спастичний параліч · Т-лімфотропний вірус людини, асоційований з мієлопатією/тропічним спастичним парапарезом типу I · Т-лімфотропний вірус людини, асоційований з мієлопатією/тропічним спастичним парапарезом типу 1 · TSP |
| zh | 热带痉挛性截瘫 | 人T淋巴细胞病毒1型相关脊髓病/热带痉挛性轻截瘫 |
| tr | Tropikal spastik paraparezi | TSP · HAM/TSP · HTLV-1-ilişkili miyelopati / tropikal spastik paraparezi · İnsan T-lenfotropik virüs tip I-ilişkili miyelopati / tropikal spastik paraparezi · İnsan T lenfotropik virüs tip 1 ilişkili miyelopati / tropikal spastik paraparezi |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| OMIM | 159580 | E | validated | |
| ICD-10 | G04.1 | E | specific | validated |
| ICD-11 | 8A45.00 | E | specific | validated |
| MONDO | 0008039 | E | validated | |
| MeSH | D015493 | E | validated | |
| UMLS | C0030481 | E | validated | |
| GARD | 8208 | E | validated | |
| MedDRA | 10044696 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (2):
- ORPHA:98010Infectious disease of the nervous system
rare neurological diseases - ORPHA:163585Rare viral disease
rare infectious diseases
No children.
Genes
0 directOrphanet records no gene directly on this code.
Prevalence and incidence
1 record| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Point prevalence | Unknown | — | Worldwide | Class only | Not yet validated | ORPHANET |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
HPO phenotypes
Orphanet has no HPO annotation for this code in this release.
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/289326
- This record as JSON: /data/d/289326.json