{"orpha":289326,"name":"Tropical spastic paraparesis","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":["HAM/TSP","HTLV-1-associated myelopathy/tropical spastic paraparesis","Human T-lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis","Human T-lymphotropic virus type-1-associated myelopathy/tropical spastic paraparesis","TSP"],"definition":"Tropical spastic paraparesis is a chronic systemic immune-mediated inflammatory myeloneuropathy, more frequently reported in women than in men, that usually presents in adulthood with slowly progressive spastic paraparesis of the lower limbs, bladder and bowel dysfunction, and sensory disturbances in the lower extremities (e.g. paresthesia and dysesthesia) and that is associated with a human T-cell lymphotropic virus type 1 (HTLV-1) infection.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-289326/","orphanet_url":"https://www.orpha.net/en/disease/detail/289326","names":{"fr":{"name":"Paraparésie spastique tropicale","synonyms":["HAM/TSP","Myélopathie associée au HTLV-1","Paraparésie spastique tropicale associée au HTLV1","Paraparésie spastique tropicale associée au virus T-lymphotrope humain de type 1","Paraparésie spastique tropicale associée au virus T-lymphotrope humain de type I","TSP"],"definition":"Myéloneuropathie inflammatoire chronique systémique à médiation immunitaire, plus fréquente chez les femmes que chez les hommes. La maladie se manifeste généralement à l'âge adulte par une paraparésie spastique lentement progressive des membres inférieurs, des troubles vésicaux et intestinaux et des troubles sensoriels affectant les membres inférieurs (de type paresthésie et dysesthésie). Elle est associée à une infection par le virus lymphotrope T humain de type 1 (HTLV-1)."},"de":{"name":"Tropische Spastische Paraparese","synonyms":["HAM/TSP","HTLV-1-assoziierte Myelopathie","Humane T-lymphotrope Virus 1-assoziierte Myelopathie/Tropische Spastische Paraparese","TSP"],"definition":"Bei der tropischen spastischen Paraparese handelt es sich um eine chronische, systemische, immunvermittelte entzündliche Myeloneuropathie, die häufiger bei Frauen als bei Männern beobachtet wird. Sie beginnt gewöhnlich im Erwachsenenalter mit langsam fortschreitender spastischer Paraparese der unteren Gliedmaßen, Blasen- und Darmstörungen und sensorischen Störungen in den unteren Extremitäten (z.B. Parästhesie und Dysästhesie). Die Erkrankung ist mit einer Infektion des humanen T-Zell-Lymphotropen Virus Typ 1 (HTLV-1) assoziiert."},"es":{"name":"Paraparesia espástica tropical","synonyms":["HAM/TSP","Paraparesia espástica tropical/mielopatía asociada al HTLV-1","Paraparesia espástica tropical/mielopatía asociada al virus linfotrópico de células T humanas tipo 1","Paraparesia espástica tropical/mielopatía asociada al virus linfotrópico de células T humanas tipo I","TSP"],"definition":"Es una mieloneuropatía sistémica crónica inflamatoria mediada por el sistema inmunitario, más frecuente en mujeres que en hombres. Por lo general, se presenta en la edad adulta con paraparesia espástica de progresión lenta acompañada de trastornos sensitivos (p. ej., parestesia y disestesia) en las extremidades inferiores y disfunción vesical e intestinal. Este trastorno está asociado a la infección por el virus linfotrópico de células T humanas tipo 1 (HTLV-1)."},"it":{"name":"Paraparesi spastica tropicale","synonyms":["HAM/TSP","Mielopatia/paraparesi spastica tropicale, associata a HTLV-1","Mielopatia/paraparesi spastica tropicale, associata a virus T-linfotropico umano tipo 1","Mielopatia/paraparesi spastica tropicale, associata a virus T-linfotropico umano tipo I","TSP"],"definition":"La paraparesi spastica tropicale è una mieloneuropatia infiammatoria immuno-mediata, sistemica e cronica, più comune nelle femmine rispetto ai maschi, che insorge di solito nell'età adulta con paraparesi spastica ad evoluzione lenta negli arti inferiori, disfunzione della vescica e dell'intestino e disturbi sensoriali a livello degli arti inferiori (parestesia e disestesia), in associazione con un'infezione da virus linfotropo delle cellule T umane di tipo 1 (HTLV-1)."},"nl":{"name":"Tropische spastische paraparese","synonyms":["HAM/TSP","HTLV-1-geassocieerde myelopathie/tropische spastische paraparese","Humaan T-lymfotroop virus type 1-geassocieerde myelopathie/tropische spastische paraparese","Humaan T-lymfotroop virus type I-geassocieerde myelopathie/tropische spastische paraparese","TSP"],"definition":"Tropische spastische paraparese is een chronische, systemische, immuun-gemedieerde inflammatoire myeloneuropathie die frequenter wordt gerapporteerd bij vrouwen dan bij mannen, die meestal tot uiting komt in de volwassenheid met traag progressieve spastische paraparese van de onderste ledematen, blaas- en darmdisfunctie, en zintuigelijke stoornissen in de onderste ledematen (e.g. paresthesie en dysesthesie), en die geassocieerd is met een infectie met een humaan T-cel-lymfotroop virus type 1 (HTLV-1)."},"pt":{"name":"Paraparésia espástica tropical","synonyms":["HAM/TSP","Mielopatia associada ao HTLV-1/paraparésia espástica tropical","Mielopatia associada ao vírus linfotrópico-T humano tipo 1/paraparésia espástica tropical","Mielopatia associada ao vírus linfotrópico-T humano tipo I/paraparésia espástica tropical","TSP"]},"pl":{"name":"Tropikalna parapareza spastyczna","synonyms":["HAM/TSP","Mielopatia/tropikalna parapareza spastyczna związana z HTLV-1","Mielopatia/tropikalna parapareza spastyczna związana z ludzkim wirusem T-limfotropowym typu 1","Mielopatia/tropikalna parapareza spastyczna związana z ludzkim wirusem T-limfotropowym typu I","TSP"]},"cs":{"name":"Tropická spastická paraparéza","synonyms":["HAM/TSP","Myelopatie/tropická spastická paraparéza asociovaná s HTLV-1","Myelopatie/tropická spastická paraparéza asociovaná s lidským T-lymfotropickým virem typu I","Myelopatie/tropická spastická paraparéza asociovaná s lidským T-lymfotropickým virem typu 1","TSP"]},"uk":{"name":"Тропічний спастичний парапарез","synonyms":["HAM/TSP","HTLV-1-асоційована мієлопатія/тропічний спастичний параліч","Т-лімфотропний вірус людини, асоційований з мієлопатією/тропічним спастичним парапарезом типу I","Т-лімфотропний вірус людини, асоційований з мієлопатією/тропічним спастичним парапарезом типу 1","TSP"],"definition":"Tropical spastic paraparesis is a chronic systemic immune-mediated inflammatory myeloneuropathy, more frequently reported in women than in men, that usually presents in adulthood with slowly progressive spastic paraparesis of the lower limbs, bladder and bowel dysfunction, and sensory disturbances in the lower extremities (e.g. paresthesia and dysesthesia) and that is associated with a human T-cell lymphotropic virus type 1 (HTLV-1) infection."},"zh":{"name":"热带痉挛性截瘫","synonyms":["人T淋巴细胞病毒1型相关脊髓病/热带痉挛性轻截瘫"],"definition":"热带痉挛性轻截瘫是一种慢性全身免疫介导的炎症性脊髓神经病，女性发病率高于男性，成年后常伴有下肢慢性进行性痉挛性双下肢瘫、膀胱和肠道功能障碍，及下肢感觉障碍（如感觉异常和感觉迟钝），其与人T淋巴细胞病毒1型（HTLV-1）感染相关。"},"tr":{"name":"Tropikal spastik paraparezi","synonyms":["TSP","HAM/TSP","HTLV-1-ilişkili miyelopati / tropikal spastik paraparezi","İnsan T-lenfotropik virüs tip I-ilişkili miyelopati / tropikal spastik paraparezi","İnsan T lenfotropik virüs tip 1 ilişkili miyelopati / tropikal spastik paraparezi"]}},"xrefs":[{"source":"OMIM","code":"159580","qualifier":"E","icd_relation":null,"validated":true},{"source":"ICD-10","code":"G04.1","qualifier":"E","icd_relation":"specific","validated":true},{"source":"ICD-11","code":"8A45.00","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"1043229589"},{"source":"MONDO","code":"0008039","qualifier":"E","icd_relation":null,"validated":true},{"source":"MeSH","code":"D015493","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0030481","qualifier":"E","icd_relation":null,"validated":true},{"source":"GARD","code":"8208","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10044696","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":68416,"name":"Rare infectious disease"},"parents":[{"orpha":98010,"name":"Infectious disease of the nervous system","classifications":[181]},{"orpha":163585,"name":"Rare viral disease","classifications":[203]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["Adult"],"prevalence":[{"type":"Point prevalence","qualification":"Class only","class":"Unknown","value":0.0,"area":"Worldwide","status":"Not yet validated","source":"ORPHANET"}],"phenotypes":null}