raremaprare-disease reference indexOrphadata 2026-06-23 · HPO 2026-09-01
ORPHA:279947

Postorgasmic illness syndrome

Synonyms: POIS

Type
Clinical syndrome
Group
Disorder
Inheritance
Not applicable
Age of onset
Adolescent, Adult
Status
active

Postorgasmic illness syndrome is a rare urogenital disease characterized by the appearance of flu-like symptoms (fever, extreme fatigue, myalgia, itchy burning eyes, nasal congestion/rhinorrhea), as well as mood changes, irritability and concentration, memory and attention difficulties, within a few minutes to a few hours after ejaculation. Symptoms disappear spontaneously 3-7 days after onset.

1

Names in Orphadata languages

12 of 12 languages
LangNameSynonyms
enPostorgasmic illness syndromePOIS
frMaladie postorgasmique= en
dePostorgasmic-Illness-Syndrom= en
esSíndrome de enfermedad postorgásmica= en
itSindrome post-orgasmica= en
nlPostorgastische ziekte-syndroom= en
ptSíndrome de doença pós-orgásmica= en
plZespół choroby postorgazmicznej= en
csPostorgasmická nemoc= en
ukСиндром посторгазмової хвороби= en
zh性高潮后疾病综合征= en
trPostorgazmik hastalık sendromu= en

Definition in:

2

Cross-references

qualifier = Orphanet mapping relation
SourceCodeQualifierICD relationValidation
ICD-10F52.3NTBTattributedvalidated
ICD-11HA02.YNTBTindexvalidated
MONDO0017213Evalidated
UMLSC4749582Evalidated
GARD10809Evalidated

E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.

3

Classification

Preferential parent (Orphanet linearisation):

Parents in the classifications (1):

No children.

4

Genes

0 direct

Orphanet records no gene directly on this code.

5

Prevalence and incidence

2 records
TypeClassValueAreaQualificationValidationSource
Point prevalence<1 / 1 000 000—WorldwideClass onlyValidatedORPHANET
Cases/families45 casesWorldwideCase(s)Validated21241453[PMID]

Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.

6

HPO phenotypes

18 annotations · validated 2016-10-31
HPOTerm (as annotated by Orphanet)Diagnostic
Very frequent (99-80%)
HP:0011446Abnormality of higher mental function
HP:0012378Fatigue
Frequent (79-30%)
HP:0000366Abnormality of the nose
HP:0001945Fever
HP:0002315Headache
HP:0000975Hyperhidrosis
HP:0000822Hypertension
HP:0000737Irritability
Occasional (29-5%)
HP:0000622Blurred vision
HP:0000750Delayed speech and language development
HP:0000716Depression
HP:0001260Dysarthria
HP:0001609Hoarse voice
HP:0003552Muscle stiffness
HP:0001324Muscle weakness
HP:0001962Palpitations
HP:0000613Photophobia
HP:0000217Xerostomia

Run the differential on the 2 obligate / very frequent terms

Annotation source: 21241453[PMID]

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Sources for this card