{"orpha":279947,"name":"Postorgasmic illness syndrome","type":"Clinical syndrome","group":"Disorder","status":"active","flags":[],"synonyms":["POIS"],"definition":"Postorgasmic illness syndrome is a rare urogenital disease characterized by the appearance of flu-like symptoms (fever, extreme fatigue, myalgia, itchy burning eyes, nasal congestion/rhinorrhea), as well as mood changes, irritability and concentration, memory and attention difficulties, within a few minutes to a few hours after ejaculation. Symptoms disappear spontaneously 3-7 days after onset.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-279947/","orphanet_url":"https://www.orpha.net/en/disease/detail/279947","names":{"fr":{"name":"Maladie postorgasmique","synonyms":["POIS"],"definition":"Une maladie urogénitale rare caractérisée par des symptômes évoquant une grippe (fièvre, fatigue extrême, myalgie, sensation d'yeux qui brûlent et qui démangent, congestion nasale/rhinorrhée), ainsi que des sautes d'humeur, une irritabilité et des troubles de la concentration, de la mémoire et de l'attention, survenant quelques minutes à quelques heures après l'éjaculation. Les symptômes disparaissent spontanément 3 à 7 jours après leur apparition."},"de":{"name":"Postorgasmic-Illness-Syndrom","synonyms":["POIS"]},"es":{"name":"Síndrome de enfermedad postorgásmica","synonyms":["POIS"],"definition":"Es una enfermedad urogenital poco frecuente caracterizada por la aparición de síntomas similares a la gripe (fiebre, fatiga extrema, mialgia, ardor pruriginoso en los ojos, congestión nasal / rinorrea), así como cambios en el estado de ánimo, irritabilidad y dificultades de concentración, memoria y atención desde unos minutos a unas pocas horas después de la eyaculación. Los síntomas desaparecen espontáneamente a los 3-7 días después del inicio."},"it":{"name":"Sindrome post-orgasmica","synonyms":["POIS"],"definition":"La sindrome post-orgasmica è una malattia urogenitale rara, caratterizzata dall'insorgenza di sintomi simil-influenzali (febbre, affaticamento estremo, mialgia, prurito e bruciore agli occhi, congestione nasale/rinorrea), sbalzi d'umore, irritabilità e difficoltà di concentrazione, difficoltà mnemoniche e di attenzione, che insorgono pochi minuti o poche ore dopo l'eiaculazione. I sintomi scompaiono spontaneamente 3-7 giorni dopo l'esordio."},"nl":{"name":"Postorgastische ziekte-syndroom","synonyms":["POIS"],"definition":"Postorgastische ziekte-syndroom is een zeldzame urogenitale ziekte die gekarakteriseerd wordt door het verschijnen van griepachtige symptomen (koorts, extreme vermoeidheid, myalgie, jeukende en branderige ogen, neuscongestie/rinorroe), alsook stemmingswisselingen, prikkelbaarheid en moeilijkheden met concentratie, geheugen en aandacht, binnen enkele minuten tot enkele uren na ejaculatie. Symptomen verdwijnen spontaan 3-7 dagen na aanvang."},"pt":{"name":"Síndrome de doença pós-orgásmica","synonyms":["POIS"]},"pl":{"name":"Zespół choroby postorgazmicznej","synonyms":["POIS"]},"cs":{"name":"Postorgasmická nemoc","synonyms":["POIS"]},"uk":{"name":"Синдром посторгазмової хвороби","synonyms":["POIS"],"definition":"Postorgasmic illness syndrome is a rare urogenital disease characterized by the appearance of flu-like symptoms (fever, extreme fatigue, myalgia, itchy burning eyes, nasal congestion/rhinorrhea), as well as mood changes, irritability and concentration, memory and attention difficulties, within a few minutes to a few hours after ejaculation. Symptoms disappear spontaneously 3-7 days after onset."},"zh":{"name":"性高潮后疾病综合征","synonyms":["POIS"],"definition":"性高潮后病情综合征是一种罕见的泌尿生殖系统疾病，其特征是在射精后几分钟到几小时内出现流感样症状（发烧、极度疲劳、肌痛、眼痒、鼻塞/鼻漏），以及情绪变化、易怒和注意力集中、记忆力和注意力困难。发病3-7天后症状自然消失。"},"tr":{"name":"Postorgazmik hastalık sendromu","synonyms":["POIS"]}},"xrefs":[{"source":"ICD-10","code":"F52.3","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"ICD-11","code":"HA02.Y","qualifier":"NTBT","icd_relation":"index","validated":true,"icd11_uri":"1094271130"},{"source":"MONDO","code":"0017213","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C4749582","qualifier":"E","icd_relation":null,"validated":true},{"source":"GARD","code":"10809","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":98023,"name":"Rare systemic or rheumatologic disease"},"parents":[{"orpha":182222,"name":"Rare systemic disease","classifications":[196]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["Adolescent","Adult"],"prevalence":[{"type":"Point prevalence","qualification":"Class only","class":"<1 / 1 000 000","value":0.0,"area":"Worldwide","status":"Validated","source":"ORPHANET"},{"type":"Cases/families","qualification":"Case(s)","class":null,"value":45.0,"area":"Worldwide","status":"Validated","source":"21241453[PMID]"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2016-10-31","source":"21241453[PMID]","terms":[{"hpo":"HP:0011446","label":"Abnormality of higher mental function","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0012378","label":"Fatigue","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0000366","label":"Abnormality of the nose","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001945","label":"Fever","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002315","label":"Headache","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000975","label":"Hyperhidrosis","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000822","label":"Hypertension","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000737","label":"Irritability","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000622","label":"Blurred vision","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000750","label":"Delayed speech and language development","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000716","label":"Depression","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001260","label":"Dysarthria","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001609","label":"Hoarse voice","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0003552","label":"Muscle stiffness","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001324","label":"Muscle weakness","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001962","label":"Palpitations","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000613","label":"Photophobia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000217","label":"Xerostomia","frequency":"Occasional (29-5%)","criteria":null}]}}