Toxic maculopathy due to antimalarial drugs
- Type
- Disease
- Group
- Disorder
- Inheritance
- Not applicable
- Age of onset
- All ages
- Status
- active
Toxic maculopathy due to antimalarial drugs is a rare, acquired eye disease, due to long-term exposure to chloroquine (CQ) or hydroxychloroquine (HCQ), characterized by a slowly progressive, usually non-reversible, development of bilateral atrophic bull's-eye maculopathy (progressive loss of central vision acuity, reduced color vision and central scotoma), which in severe cases can spread over the entire fundus, leading to widespread retinal atrophy and visual loss.
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Toxic maculopathy due to antimalarial drugs | |
| fr | Maculopathie toxique due aux antipaludéens | |
| de | Makulopathie, toxische, durch anti-Malaria-Medikamente | |
| es | Maculopatía tóxica por antimaláricos | |
| it | Maculopatia tossica da farmaci antimalarici | |
| nl | Toxische maculopathie door antimalariamiddel | |
| pt | Maculopatia tóxica por fármacos antimaláricos | |
| pl | Toksyczna makulopatia spowodowana lekami przeciwmalarycznymi | |
| cs | Toxická makulopatie způsobená antimalariky | |
| uk | Токсична макулопатія внаслідок прийому протималярійних препаратів | |
| zh | 抗疟药所致中毒性黄斑病变 | |
| tr | Antimalaryal ilaçlara bağlı toksik makulopati |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | H35.3 | NTBT | attributed | validated |
| ICD-10 | T37.2 | NTBT | attributed | validated |
| ICD-11 | 9B78.3Y | NTBT | attributed | validated |
| MONDO | 0017204 | E | validated | |
| UMLS | C4706522 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (1):
- ORPHA:716432Rare isolated progressive predominantly macular disorder
rare ophthalmic disorders
No children.
Genes
0 directOrphanet records no gene directly on this code.
Prevalence and incidence
1 record| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Point prevalence | Unknown | — | Worldwide | Class only | Not yet validated | ORPHANET |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
HPO phenotypes
Orphanet has no HPO annotation for this code in this release.
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/279894
- This record as JSON: /data/d/279894.json