Drug- or toxin-induced pulmonary arterial hypertension
Synonyms: Drug- or toxin-induced PAH
- Type
- Clinical group
- Group
- Group of disorders
- Inheritance
- Multigenic/multifactorial
- Age of onset
- Adolescent, Adult, Childhood, Elderly
- Status
- active
Drug- or toxin-induced pulmonary arterial hypertension (PAH) is a form of pulmonary arterial hypertension (PAH) secondary to the exposition to drugs. Drug- or toxin-induced PAH is characterized by elevated pulmonary arterial resistance leading to right heart failure. Drug or toxin induced PAH is progressive and potentially fatal.
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Drug- or toxin-induced pulmonary arterial hypertension | Drug- or toxin-induced PAH |
| fr | Hypertension artérielle pulmonaire médicamenteuse ou toxique | HTAP médicamenteuse ou toxique |
| de | Pulmonale arterielle Hypertonie, Medikamenten- oder Toxin-induzierte | PAH, Medikamenten- oder Toxin-induzierte |
| es | Hipertensión arterial pulmonar inducida por fármacos o toxinas | HAP inducida por drogas o toxinas |
| it | Ipertensione arteriosa polmonare indotta dalle tossine o dai farmaci | PAH indotta dalle tossine o dai farmaci |
| nl | Medicatie- of toxinegeïnduceerde pulmonale arteriële hypertensie | Medicatie- of toxinegeïnduceerde PAH |
| pt | Hipertensão arterial pulmonar induzida por fármacos ou toxinas | |
| pl | Tętnicze nadciśnienie płucne indukowane lekiem lub toksyną | PAH inukowane lekiem lub toksyną |
| cs | Plicní arteriální hypertenze indukovaná léky nebo toxinem | Léky nebo toxinem indukovaná PAH |
| uk | Легенева артеріальна гіпертензія, спричинена лікарськими засобами або токсинами | ЛАГ, спричинена лікарськими засобами або токсинами |
| zh | 药物或毒素引起的肺动脉高压 | 药物或毒物引起的PAH |
| tr | İlaç veya toksin kaynaklı pulmoner arteriyel hipertansiyon | İlaç veya toksin kaynaklı PAH |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| MONDO | 0017149 | E | validated | |
| MONDO | 17149 | E | validated | |
| UMLS | C0340544 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (1):
- ORPHA:182090Pulmonary arterial hypertension
rare respiratory diseases; rare transplant-related disorders
No children.
Genes
1 direct| Gene | Association | Status | HGNC | Ensembl | OMIM | Locus | Name | Source of validation |
|---|---|---|---|---|---|---|---|---|
| BMPR2 | Major susceptibility factor in | Assessed | HGNC:1078 | ENSG00000204217 | 600799 | 2q33.1-q33.2 | bone morphogenetic protein receptor type 2 | 22523367[PMID] |
Prevalence and incidence
1 record| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Point prevalence | 1-9 / 1 000 000 | — | France | Class only | Validated | 16456139[PMID]_ORPHANET |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
HPO phenotypes
Orphanet has no HPO annotation for this code in this release.
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/275786
- This record as JSON: /data/d/275786.json