{"orpha":275786,"name":"Drug- or toxin-induced pulmonary arterial hypertension","type":"Clinical group","group":"Group of disorders","status":"active","flags":[],"synonyms":["Drug- or toxin-induced PAH"],"definition":"Drug- or toxin-induced pulmonary arterial hypertension (PAH) is a form of pulmonary arterial hypertension (PAH) secondary to the exposition to drugs. Drug- or toxin-induced PAH is characterized by elevated pulmonary arterial resistance leading to right heart failure. Drug or toxin induced PAH is progressive and potentially fatal.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-275786/","orphanet_url":"https://www.orpha.net/en/disease/detail/275786","names":{"fr":{"name":"Hypertension artérielle pulmonaire médicamenteuse ou toxique","synonyms":["HTAP médicamenteuse ou toxique"],"definition":"Forme d'hypertension artérielle pulmonaire (HAP) secondaire à l'exposition à des médicaments. L'hypertension artérielle pulmonaire médicamenteuse ou toxique se caractérise par une résistance artérielle pulmonaire élevée entraînant une insuffisance cardiaque droite. L'HAP médicamenteuse ou toxique est progressive et potentiellement létale."},"de":{"name":"Pulmonale arterielle Hypertonie, Medikamenten- oder Toxin-induzierte","synonyms":["PAH, Medikamenten- oder Toxin-induzierte"],"definition":"Die Medikamenten- oder Toxininduzierte pulmonal-arterielle Hypertonie (PAH) ist eine Form der pulmonal-arteriellen Hypertonie (PAH, siehe dort), die sekundär durch die Exposition gegenüber Medikamenten entsteht. Sie ist durch einen erhöhten pulmonal-arteriellen Widerstand gekennzeichnet, der zu Rechtsherzversagen führt. Die Medikamenten- oder Toxininduzierte PAH ist progressiv und potenziell tödlich."},"es":{"name":"Hipertensión arterial pulmonar inducida por fármacos o toxinas","synonyms":["HAP inducida por drogas o toxinas"],"definition":"Es una forma de hipertensión arterial pulmonar (HAP) derivada de la exposición a fármacos caracterizada por una elevada resistencia arterial pulmonar conducente a insuficiencia cardíaca derecha. La enfermedad es progresiva y potencialmente mortal."},"it":{"name":"Ipertensione arteriosa polmonare indotta dalle tossine o dai farmaci","synonyms":["PAH indotta dalle tossine o dai farmaci"],"definition":"L'ipertensione arteriosa polmonare (PAH) indotta dai farmaci o dalle tossine è una forma di ipertensione arteriosa polmonare (PAH; si veda questo termine), secondaria all'esposizione ai farmaci. La malattia è caratterizzata da un'elevata resistenza delle arterie polmonari che esita nell'insufficienza della parte destra del cuore. La PAH indotta dai farmaci o dalle tossine è una malattia progressiva e potenzialmente letale."},"nl":{"name":"Medicatie- of toxinegeïnduceerde pulmonale arteriële hypertensie","synonyms":["Medicatie- of toxinegeïnduceerde PAH"],"definition":"Geneesmiddel- of toxine-geïnduceerde pulmonale arteriële hypertensie (PAH) is een vorm van pulmonale arteriële hypertensie (PAH; zie deze term) die secundair is aan de blootstelling aan geneesmiddelen. Geneesmiddel- of toxine-geïnduceerde PAH wordt gekarakteriseerd door een verhoogde weerstand in de longslagaders, wat leidt tot rechtszijdig hartfalen. Geneesmiddel- of toxine-geïnduceerde PAH is progressief en potentieel fataal."},"pt":{"name":"Hipertensão arterial pulmonar induzida por fármacos ou toxinas"},"pl":{"name":"Tętnicze nadciśnienie płucne indukowane lekiem lub toksyną","synonyms":["PAH inukowane lekiem lub toksyną"]},"cs":{"name":"Plicní arteriální hypertenze indukovaná léky nebo toxinem","synonyms":["Léky nebo toxinem indukovaná PAH"]},"uk":{"name":"Легенева артеріальна гіпертензія, спричинена лікарськими засобами або токсинами","synonyms":["ЛАГ, спричинена лікарськими засобами або токсинами"],"definition":"Drug- or toxin-induced pulmonary arterial hypertension (PAH) is a form of pulmonary arterial hypertension (PAH, see this term) secondary to the exposition to drugs. Drug- or toxin-induced PAH is characterized by elevated pulmonary arterial resistance leading to right heart failure. Drug or toxin induced PAH is progressive and potentially fatal."},"zh":{"name":"药物或毒素引起的肺动脉高压","synonyms":["药物或毒物引起的PAH"],"definition":"药物或毒素所致的肺动脉高压(PAH)是继药物暴露之后的肺动脉高压(PAH)的一种形式。药物或毒素诱导的肺动脉高压的特点是肺动脉阻力升高导致右心衰竭。药物或毒素引起的PAH是进行性的，具有潜在的致命性。"},"tr":{"name":"İlaç veya toksin kaynaklı pulmoner arteriyel hipertansiyon","synonyms":["İlaç veya toksin kaynaklı PAH"]}},"xrefs":[{"source":"MONDO","code":"0017149","qualifier":"E","icd_relation":null,"validated":true},{"source":"MONDO","code":"17149","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0340544","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":97955,"name":"Rare respiratory disease"},"parents":[{"orpha":182090,"name":"Pulmonary arterial hypertension","classifications":[184,233]}],"children":[],"genes":[{"symbol":"BMPR2","name":"bone morphogenetic protein receptor type 2","gene_type":"gene with protein product","association":"Major susceptibility factor in","status":"Assessed","source":"22523367[PMID]","hgnc":"1078","ensembl":"ENSG00000204217","omim":"600799","loci":["2q33.1-q33.2"]}],"genes_via_subtypes":[],"inheritance":["Multigenic/multifactorial"],"onset":["Adolescent","Adult","Childhood","Elderly"],"prevalence":[{"type":"Point prevalence","qualification":"Class only","class":"1-9 / 1 000 000","value":0.0,"area":"France","status":"Validated","source":"16456139[PMID]_ORPHANET"}],"phenotypes":null}