Trigeminal neuralgia
- Type
- Disease
- Group
- Disorder
- Inheritance
- Not applicable
- Age of onset
- Adolescent, Adult, Elderly
- Status
- active
A rare acquired peripheral neuropathy characterized by paroxysmal, sharp, stabbing, electric-shock-like orofacial pain, that is restricted to one or more of the trigeminal nerve divisions and mostly unilateral. Attacks are brief (few seconds to a maximum of two minutes), but typically occur repeatedly and periodically, can arise spontaneously or be triggered by innocuous stimuli, and are frequently accompanied by tic-like cramps of facial muscles. The condition affects women more often than men.
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Trigeminal neuralgia | |
| fr | Névralgie trigéminale | Névralgie du trijumeau · Tic douloureux |
| de | Trigeminusneuralgie | Tic douloureux |
| es | Neuralgia trigeminal | Tic doloroso |
| it | Nevralgia del trigemino | |
| nl | Trigeminusneuralgie | Tic douloureux |
| pt | Neuralgia do trigémio | |
| pl | Neuralgia nerwu trójdzielnego | |
| cs | Neuralgie trigeminu | |
| uk | Невралгія трійчастого нерва | |
| zh | 三叉神经痛 | |
| tr | Trigeminal nevralji |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| OMIM | 190400 | E | validated | |
| ICD-10 | G50.0 | E | specific | validated |
| ICD-11 | 8B82.0 | E | specific | validated |
| MONDO | 0008599 | E | validated | |
| MeSH | D014277 | E | validated | |
| UMLS | C0040997 | E | validated | |
| GARD | 7805 | E | validated | |
| MedDRA | 10044652 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (1):
- ORPHA:221109Cranial neuralgia
rare neurological diseases
No children.
Genes
0 directOrphanet records no gene directly on this code.
Prevalence and incidence
3 records| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Point prevalence | Unknown | — | Worldwide | Class only | Validated | ORPHANET |
| Annual incidence | 1-9 / 100 000 | 4.3 / 100 000 | United States | Value and class | Validated | 15062534[PMID] |
| Annual incidence | 1-9 / 100 000 | 8 / 100 000 | United Kingdom | Value and class | Validated | 10733998[PMID] |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
HPO phenotypes
17 annotations · validated 2018-09-19| HPO | Term (as annotated by Orphanet) | Diagnostic |
|---|---|---|
| Obligate (100%) | ||
| HP:0100661 | Trigeminal neuralgia | |
| Very frequent (99-80%) | ||
| HP:0012533 | Allodynia | |
| HP:0012199 | Cluster headache | |
| HP:0000716 | Depression | |
| Frequent (79-30%) | ||
| HP:0000740 | Episodic paroxysmal anxiety | |
| HP:0011968 | Feeding difficulties | |
| HP:0200025 | Mandibular pain | |
| HP:0003401 | Paresthesia | |
| HP:0002465 | Poor speech | |
| HP:0003474 | Somatic sensory dysfunction | |
| HP:0000183 | Tongue muscle weakness | |
| HP:0004948 | Vascular tortuosity | |
| Occasional (29-5%) | ||
| HP:0007305 | CNS demyelination | |
| HP:0001293 | Cranial nerve compression | |
| HP:0002664 | Neoplasm | |
| HP:0200026 | Ocular pain | |
| HP:0011096 | Peripheral demyelination | |
Run the differential on the 4 obligate / very frequent terms
Annotation source: 12940815[PMID]_11960159[PMID]_11565877[PMID]_1983882[PMID]_24534115[PMID]_27306631[PMID]_2716987[PMID]_5334334[PMID]_14315671[PMID]
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/221091
- This record as JSON: /data/d/221091.json