{"orpha":221091,"name":"Trigeminal neuralgia","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":[],"definition":"A rare acquired peripheral neuropathy characterized by paroxysmal, sharp, stabbing, electric-shock-like orofacial pain, that is restricted to one or more of the trigeminal nerve divisions and mostly unilateral. Attacks are brief (few seconds to a maximum of two minutes), but typically occur repeatedly and periodically, can arise spontaneously or be triggered by innocuous stimuli, and are frequently accompanied by tic-like cramps of facial muscles. The condition affects women more often than men.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-221091/","orphanet_url":"https://www.orpha.net/en/disease/detail/221091","names":{"fr":{"name":"Névralgie trigéminale","synonyms":["Névralgie du trijumeau","Tic douloureux"],"definition":"Neuropathie périphérique acquise rare caractérisée par des douleurs orofaciales paroxystiques, aiguës, en coup de poignard, semblables à des chocs électriques, limitées à une ou plusieurs divisions du nerf trijumeau et le plus souvent unilatérales. Les crises sont brèves (allant de quelques secondes à un maximum de deux minutes), mais se produisent généralement de manière répétée et périodique et pouvant survenir spontanément ou être déclenchées par des stimuli non douloureux. Elles sont souvent accompagnées de crampes des muscles faciaux semblables à des tics. Les femmes sont plus souvent touchées que les hommes."},"de":{"name":"Trigeminusneuralgie","synonyms":["Tic douloureux"],"definition":"Eine seltene erworbene periphere Neuropathie, die durch paroxysmale, scharfe, stechende, elektroschockartige orofaziale Schmerzen gekennzeichnet ist, die auf einen oder mehrere Abschnitte des Nervus trigeminus beschränkt und meist einseitig sind. Die Anfälle sind kurz (wenige Sekunden bis maximal zwei Minuten), treten aber typischerweise wiederholt und periodisch auf, können spontan auftreten oder durch harmlose Reize ausgelöst werden und werden häufig von tic-artigen Krämpfen der Gesichtsmuskeln begleitet. Frauen sind häufiger von der Krankheit betroffen als Männer."},"es":{"name":"Neuralgia trigeminal","synonyms":["Tic doloroso"],"definition":"Es una neuropatía periférica adquirida poco frecuente caracterizada por un dolor orofacial paroxístico, agudo, punzante, similar a una descarga eléctrica, que se limita a una o más de las divisiones del nervio trigémino, siendo principalmente unilateral. Los ataques son breves (de unos pocos segundos a un máximo de dos minutos), aunque, por lo general, ocurren de manera repetida y periódica. Pueden surgir espontáneamente o desencadenados por estímulos inocuos y, con frecuencia, van acompañados de calambres en los músculos faciales similares a un tic. El trastorno afecta a las mujeres con mayor frecuencia que a los varones."},"it":{"name":"Nevralgia del trigemino","definition":"Si tratta di una neuropatia periferica acquisita rara, caratterizzata dal dolore orofacciale parossistico, intenso e pungente, simile alle scosse elettriche, limitato a una o più divisioni del nervo trigemino, per lo più monolaterale. Gli attacchi sono brevi (da qualche secondo fino ad un massimo di due minuti), ma in genere si manifestano ripetutamente e periodicamente, in maniera spontanea oppure scatenati da stimoli innocui; spesso si associano a crampi dei muscoli facciali, simili a dei tic. Le femmine sono maggiormente colpite."},"nl":{"name":"Trigeminusneuralgie","synonyms":["Tic douloureux"],"definition":"Een zeldzame, verworven perifere neuropathie, gekarakteriseerd door paroxysmale, scherpe, stekende, op een elektrische schok gelijkende orofaciale pijn die beperkt blijft tot een of meerdere afsplitsingen van nervus trigeminus en die meestal unilateraal voorkomt. Aanvallen zijn kort (enkele seconden tot maximaal twee minuten), maar treden doorgaans herhaaldelijk en periodiek op, kunnen spontaan ontstaan of uitgelokt worden door onschadelijke stimuli, en gaan vaak gepaard met tic-achtige krampen van aangezichtsspieren. De aandoening treft vaker vrouwen dan mannen."},"pt":{"name":"Neuralgia do trigémio"},"pl":{"name":"Neuralgia nerwu trójdzielnego"},"cs":{"name":"Neuralgie trigeminu"},"uk":{"name":"Невралгія трійчастого нерва","definition":"A rare acquired peripheral neuropathy characterized by paroxysmal, sharp, stabbing, electric-shock-like orofacial pain, that is restricted to one or more of the trigeminal nerve divisions and mostly unilateral. Attacks are brief (few seconds to a maximum of two minutes), but typically occur repeatedly and periodically, can arise spontaneously or be triggered by innocuous stimuli, and are frequently accompanied by tic-like cramps of facial muscles. The condition affects women more often than men."},"zh":{"name":"三叉神经痛","definition":"一种罕见的获得性周围神经病变，以阵发性、尖锐、剧烈、电击样口面部疼痛为特征，局限于三叉神经的一个或多个分支，多为单侧表现。发作是短暂的（几秒钟到最多两分钟），但通常反复和周期性地发生，可自发发生或由无害的刺激触发，并经常伴有抽动样面部肌肉抽筋。该病对女性的影响比男性更大。"},"tr":{"name":"Trigeminal nevralji"}},"xrefs":[{"source":"OMIM","code":"190400","qualifier":"E","icd_relation":null,"validated":true},{"source":"ICD-10","code":"G50.0","qualifier":"E","icd_relation":"specific","validated":true},{"source":"ICD-11","code":"8B82.0","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"1803581281"},{"source":"MONDO","code":"0008599","qualifier":"E","icd_relation":null,"validated":true},{"source":"MeSH","code":"D014277","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0040997","qualifier":"E","icd_relation":null,"validated":true},{"source":"GARD","code":"7805","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10044652","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":98006,"name":"Rare neurologic disease"},"parents":[{"orpha":221109,"name":"Cranial neuralgia","classifications":[181]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["Adolescent","Adult","Elderly"],"prevalence":[{"type":"Point prevalence","qualification":"Class only","class":"Unknown","value":0.0,"area":"Worldwide","status":"Validated","source":"ORPHANET"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":4.3,"area":"United States","status":"Validated","source":"15062534[PMID]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":8.0,"area":"United Kingdom","status":"Validated","source":"10733998[PMID]"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2018-09-19","source":"12940815[PMID]_11960159[PMID]_11565877[PMID]_1983882[PMID]_24534115[PMID]_27306631[PMID]_2716987[PMID]_5334334[PMID]_14315671[PMID]","terms":[{"hpo":"HP:0100661","label":"Trigeminal neuralgia","frequency":"Obligate (100%)","criteria":null},{"hpo":"HP:0012533","label":"Allodynia","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0012199","label":"Cluster headache","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0000716","label":"Depression","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0000740","label":"Episodic paroxysmal anxiety","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0011968","label":"Feeding difficulties","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0200025","label":"Mandibular pain","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0003401","label":"Paresthesia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002465","label":"Poor speech","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0003474","label":"Somatic sensory dysfunction","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000183","label":"Tongue muscle weakness","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0004948","label":"Vascular tortuosity","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0007305","label":"CNS demyelination","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001293","label":"Cranial nerve compression","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002664","label":"Neoplasm","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0200026","label":"Ocular pain","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0011096","label":"Peripheral demyelination","frequency":"Occasional (29-5%)","criteria":null}]}}