5-fluorouracil poisoning
Synonyms: 5-fluorouracil intoxication
- Type
- Particular clinical situation in a disease or syndrome
- Group
- Disorder
- Inheritance
- Not applicable
- Age of onset
- Adult, Elderly
- Status
- active
A rare intoxication caused by the prolonged, low-dose administration of 5-fluorouracil, which is the mainstay of both adjuvant and advanced-disease chemotherapy regimens in colon cancer. 5-fluorouracil poisoning is characterized by gastrointestinal (nausea, emesis, diarrhea, anorexia, stomatitis) and hematologic (myelosuppression) toxicities as well as mucositis, alopecia and, occasionally, palmar-plantar dysesthesia (more commonly known as hand-foot syndrome). Women have been reported to experience more 5-fluorouracil-related toxicity than men.
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | 5-fluorouracil poisoning | 5-fluorouracil intoxication |
| fr | Intoxication au 5-fluorouracile | Surdosage en 5-fluorouracile |
| de | 5-Fluorouracil-Vergiftung | 5-Fluorouracil-Intoxikation |
| es | Intoxicación por 5-fluorouracilo | |
| it | Avvelenamento da 5-fluorouracile | Intossicazione da 5-fluorouracile |
| nl | 5-fluorouracilvergiftiging | 5-fluorouracilintoxicatie |
| pt | Sobredosagem de 5-fluorouracilo | |
| pl | Zatrucie 5-fluorouracylem | Intoksykacja 5-fluorouracylem |
| cs | Otrava 5-fluorouracilem | Intoxikace 5-fluorouracilem |
| uk | Отруєння 5-фторурацилом | Інтоксикація 5-фторурацилом |
| zh | 5-氟尿嘧啶中毒 | 5-氟尿嘧啶中毒 |
| tr | 5-flurourasil zehirlenmesi | 5-florourasil zehirlenmesi |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | T45.1 | NTBT | attributed | validated |
| ICD-11 | NE60 | NTBT | attributed | validated |
| MONDO | 0016312 | E | validated | |
| UMLS | C0274576 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (1):
- ORPHA:306640Rare intoxication due to medical products
rare disorders due to toxic effects
No children.
Genes
0 directOrphanet records no gene directly on this code.
Prevalence and incidence
1 record| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Point prevalence | 1-9 / 100 000 | 2 / 100 000 | Europe | Value and class | Validated | European Medicines Agency[OTHER] |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
HPO phenotypes
Orphanet has no HPO annotation for this code in this release.
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/217064
- This record as JSON: /data/d/217064.json