{"orpha":217064,"name":"5-fluorouracil poisoning","type":"Particular clinical situation in a disease or syndrome","group":"Disorder","status":"active","flags":[],"synonyms":["5-fluorouracil intoxication"],"definition":"A rare intoxication caused by the prolonged, low-dose administration of 5-fluorouracil, which is the mainstay of both adjuvant and advanced-disease chemotherapy regimens in colon cancer. 5-fluorouracil poisoning is characterized by gastrointestinal (nausea, emesis, diarrhea, anorexia, stomatitis) and hematologic (myelosuppression) toxicities as well as mucositis, alopecia and, occasionally, palmar-plantar dysesthesia (more commonly known as hand-foot syndrome). Women have been reported to experience more 5-fluorouracil-related toxicity than men.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-217064/","orphanet_url":"https://www.orpha.net/en/disease/detail/217064","names":{"fr":{"name":"Intoxication au 5-fluorouracile","synonyms":["Surdosage en 5-fluorouracile"],"definition":"Intoxication rare causée par l'administration prolongée de faibles doses de 5-fluorouracile, traitement de base par chimiothérapie adjuvante et celui d'un stade avancé du cancer colorectal. L'intoxication au 5-fluorouracile se caractérise par une intoxication gastro-intestinale (nausées, vomissements, diarrhée, anorexie, stomatite) et hématologique (myélosuppression), ainsi que par une mucosite, une alopécie et, occasionnellement, par une dysesthésie palmo-plantaire (plus connue sous le nom de syndrome main-pied). Selon les cas rapportés, la toxicité au 5-FU est plus fréquente chez les femmes."},"de":{"name":"5-Fluorouracil-Vergiftung","synonyms":["5-Fluorouracil-Intoxikation"],"definition":"Eine seltene Vergiftung, die durch die längere, niedrig dosierte Verabreichung von 5-Fluorouracil verursacht wird, das die Hauptstütze sowohl der adjuvanten als auch der fortgeschrittenen Chemotherapie bei Dickdarmkrebs ist. Eine 5-Fluorouracil-Vergiftung ist durch gastrointestinale (Übelkeit, Erbrechen, Durchfall, Anorexie, Stomatitis) und hämatologische (Myelosuppression) Toxizitäten sowie Mukositis, Alopezie und gelegentlich auch durch palmar-plantare Dysästhesie (besser bekannt als Hand-Fuß-Syndrom) gekennzeichnet. Berichten zufolge sind Frauen stärker von 5-Fluorouracil-bedingten Toxizitäten betroffen als Männer."},"es":{"name":"Intoxicación por 5-fluorouracilo","definition":"Es una intoxicación rara causada por la administración prolongada y a dosis bajas de 5-FU, que constituye la terapia de base en el tratamiento quimioterapéutico, tanto adyuvante como en casos de enfermedad avanzada, del cáncer de colon. Está caracterizado por toxicidad gastrointestinal (náusea, emesis, diarrea, anorexia, estomatitis) y hematológica (mielosupresión), así como mucositis, alopecia y, ocasionalmente, disestesia palmo-plantar (más comúnmente conocida como síndrome de mano-pie). Se ha descrito que las mujeres experimentan mayor toxicidad asociada a 5-FU que los varones."},"it":{"name":"Avvelenamento da 5-fluorouracile","synonyms":["Intossicazione da 5-fluorouracile"],"definition":"L'avvelenamento da 5-fluorouracile (5-FU) è un'intossicazione rara causata dall'assunzione prolungata di basse dosi di 5-FU, una molecola importante sia nella chemioterapia adiuvante che in quella utilizzata negli stadi avanzati del tumore del colon. L'avvelenamento da 5-fluorouracile è caratterizzato da tossicità a livello gastrointestinale (nausea, emesi, diarrea, anoressia, stomatite) ed ematologico (mielosoppressione), mucosite, alopecia e, raramente, disestesia palmo-plantare (nota anche come sindrome mano-piede). Le femmine sono maggiormente suscettibili alla tossicità da 5-FU rispetto ai maschi."},"nl":{"name":"5-fluorouracilvergiftiging","synonyms":["5-fluorouracilintoxicatie"],"definition":"Een zeldzame intoxicatie veroorzaakt door langdurige toediening van 5-fluoro-uracil in lage doses, de hoofdpijler van zowel adjuvant behandelregime als chemotherapie voor gevorderde ziekte bij darmkanker. Vergiftiging door 5-fluoro-uracil wordt gekenmerkt door gastro-intestinale (misselijkheid, braken, diarree, anorexie, stomatitis) en hematologische (myelosuppressie) toxiciteit, alsook mucositis, alopecie en soms, palmoplantaire dysesthesie (beter gekend als hand-voet-syndroom). Er werd gemeld dat vrouwen meer toxiciteit gerelateerd aan 5-fluoro-uracil ervaren dan mannen."},"pt":{"name":"Sobredosagem de 5-fluorouracilo"},"pl":{"name":"Zatrucie 5-fluorouracylem","synonyms":["Intoksykacja 5-fluorouracylem"]},"cs":{"name":"Otrava 5-fluorouracilem","synonyms":["Intoxikace 5-fluorouracilem"]},"uk":{"name":"Отруєння 5-фторурацилом","synonyms":["Інтоксикація 5-фторурацилом"],"definition":"A rare intoxication caused by the prolonged, low-dose administration of 5-fluorouracil, which is the mainstay of both adjuvant and advanced-disease chemotherapy regimens in colon cancer. 5-fluorouracil poisoning is characterized by gastrointestinal (nausea, emesis, diarrhea, anorexia, stomatitis) and hematologic (myelosuppression) toxicities as well as mucositis, alopecia and, occasionally, palmar-plantar dysesthesia (more commonly known as hand-foot syndrome). Women have been reported to experience more 5-fluorouracil-related toxicity than men."},"zh":{"name":"5-氟尿嘧啶中毒","synonyms":["5-氟尿嘧啶中毒"],"definition":"5-氟尿嘧啶（5-FU）中毒是一种罕见的因长期、低剂量服用5-FU引起的中毒。5-FU是结肠癌辅助化疗和晚期疾病化疗的主要手段。5-氟尿嘧啶中毒的特征是胃肠道毒性（恶心、呕吐、腹泻、厌食、口炎）和血液学毒性（骨髓抑制），以及粘膜炎、脱发，偶尔还有掌跖感觉障碍（通常称为手足综合征）。据报道，女性的5-FU相关中毒比男性更多。"},"tr":{"name":"5-flurourasil zehirlenmesi","synonyms":["5-florourasil zehirlenmesi"]}},"xrefs":[{"source":"ICD-10","code":"T45.1","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"ICD-11","code":"NE60","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"MONDO","code":"0016312","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0274576","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":108999,"name":"Rare disorder due to toxic effects"},"parents":[{"orpha":306640,"name":"Rare intoxication due to medical products","classifications":[204]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["Adult","Elderly"],"prevalence":[{"type":"Point prevalence","qualification":"Value and class","class":"1-9 / 100 000","value":2.0,"area":"Europe","status":"Validated","source":"European Medicines Agency[OTHER]"}],"phenotypes":null}