Serous carcinoma of the corpus uteri
Synonyms: Endometrial serous carcinoma
- Type
- Disease
- Group
- Disorder
- Status
- active
A rare high-grade endometrial carcinoma characterized by diffuse, marked nuclear pleomorphism, typically exhibiting complex papillary and/or glandular growth patterns and showing abnormal p53 and diffuse p16 immunohistochemistry. The tumor typically arises in atrophic endometrium or in an endometrial polyp. Most patients present with postmenopausal bleeding. Extrauterine metastasis is present in 40-50% of surgically staged cases, most frequently involving lymph nodes or peritoneal sites and omentum. Patients with extrauterine spread have poor outcomes, while endometrium-limited carcinoma has a better prognosis.
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Serous carcinoma of the corpus uteri | Endometrial serous carcinoma |
| fr | Carcinome séreux du corps de l'utérus | Carcinome séreux de l'endomètre |
| de | Seröses Karzinom des Corpus uteri | Endometriumkarzinom, seröses |
| es | Carcinoma seroso de cuerpo de útero | Carcinoma papilar del endometrio · Carcinoma seroso del endometrio |
| it | Carcinoma sieroso del corpo dell'utero | Carcinoma sieroso dellendometrio |
| nl | Sereus carcinoom van corpus uteri | Endometriaal sereus carcinoom · Sereus carcinoom van baarmoederlichaam |
| pt | Carcinoma seroso do corpo uterino | Carcinoma seroso endometrial |
| pl | Rak surowiczy trzonu macicy | Rak włośniczkowy endometrium · Rak surowiczy trzonu macicy |
| cs | Serózní karcinom corpus uteri | Endometriální kapilární karcinom |
| uk | Серозна карцинома тіла матки | Серозна карцинома ендометрія |
| zh | 子宫体乳头状癌 | 子宫内膜毛细血管癌 |
| tr | Korpus uteri papiller karsinomu | Endometrial kapiller karsinom |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | C54.1 | BTNT | attributed | validated |
| ICD-11 | 2C76.Y | NTBT | attributed | validated |
| MONDO | 0016268 | E | validated | |
| UMLS | C5679804 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (1):
- ORPHA:213569Rare cancer of corpus uteri
rare neoplastic diseases; rare gynecological and obstetric diseases
No children.
Genes
1 direct| Gene | Association | Status | HGNC | Ensembl | OMIM | Locus | Name | Source of validation |
|---|---|---|---|---|---|---|---|---|
| ERBB2 | Biomarker tested in | Assessed | HGNC:3430 | ENSG00000141736 | 164870 | 17q12 | erb-b2 receptor tyrosine kinase 2 | 38443321[PMID] |
Prevalence and incidence
0 recordsNo prevalence record in this release.
HPO phenotypes
Orphanet has no HPO annotation for this code in this release.
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/213726
- This record as JSON: /data/d/213726.json