Overlap myositis
Synonyms: Adult-onset overlap myositis · Non-specific myositis
- Type
- Disease
- Group
- Disorder
- Inheritance
- Not applicable
- Age of onset
- Adult
- Status
- active
A rare idiopathic inflammatory myopathy (IIM) with a heterogeneous phenotype characterized by myositis with at least one clinical and/or autoantibody overlap feature. Possible clinical overlap features include polyarthritis, Raynaud's phenomenon, sclerodactyly, scleroderma (proximal to metacarpophalangeal joints), lung interstitial pneumonia, and/or clinical signs of systemic lupus erythematosus (SLE).
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Overlap myositis | Adult-onset overlap myositis · Non-specific myositis |
| fr | Myosite de chevauchement | Myosite de chevauchement de l'adulte · Myosite non spécifique |
| de | Overlap-Myositis | Myositis, unspezifische · Myositis-Überlappungssyndrom mit Beginn im Erwachsenenalter |
| es | Miositis de solapamiento | Miositis de solapamiento de inicio en el adulto · Miositis no específica |
| it | Miosite da sovrapposizione | Miosite da sovrapposizione a esordio nell'età adulta |
| nl | Overlapmyositis | Niet-specifieke myositis · Overlapmyositis met aanvang op volwassen leeftijd |
| pt | Miosite de sobreposição | |
| pl | Zapalenie mięśni typu "overlap | Niespecyficzne zapalenie mięśni · Zapalenie mięśni typu "overlap" o początku w wieku dorosłym |
| cs | Překryvná myozitida | Překryvná myozitida s počátkem v dospělosti |
| uk | Overlap-міозит | Накладання міозиту у дорослих · Неспецифічний міозит |
| zh | 重叠肌炎 | 成人起病重叠肌炎 |
| tr | Örtüşen miyozit | Spesifik olmayan miyozit · Erişkin başlangıçlı örtüşen miyozit |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | M33.2 | NTBT | attributed | validated |
| MONDO | 0016099 | E | validated | |
| UMLS | C5679784 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (1):
- ORPHA:98482Idiopathic inflammatory myopathy
rare neurological diseases; rare systemic and rheumatological diseases
No children.
Genes
0 directOrphanet records no gene directly on this code.
Prevalence and incidence
1 record| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Point prevalence | Unknown | — | Europe | Class only | Not yet validated | ORPHANET |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
HPO phenotypes
40 annotations · validated 2021-12-02| HPO | Term (as annotated by Orphanet) | Diagnostic |
|---|---|---|
| Frequent (79-30%) | ||
| HP:0003119 | Abnormal circulating lipid concentration | |
| HP:0034088 | Anti-Ku antibody positivity | |
| HP:0033560 | Anti-PM-Scl antibody positivity | |
| HP:0033555 | Anti-Ro/SS-A antibody positivity | |
| HP:0034093 | Anti-Ro52/TRIM21 antibody positivity | |
| HP:0033040 | Anti-Sm antibody positivity | |
| HP:0030859 | Anti-topoisomerase I antibody positivity | |
| HP:0003493 | Antinuclear antibody positivity | |
| HP:0001369 | Arthritis | |
| HP:0002960 | Autoimmunity | |
| HP:0025142 | Constitutional symptom | |
| HP:0002015 | Dysphagia | |
| HP:0003236 | Elevated circulating creatine kinase concentration | |
| HP:0025131 | Finger swelling | |
| HP:0000822 | Hypertension | |
| HP:0100296 | Perifascicular muscle fiber atrophy | |
| HP:0003701 | Proximal muscle weakness | |
| HP:0008997 | Proximal muscle weakness in upper limbs | |
| HP:0030880 | Raynaud phenomenon | |
| HP:0011838 | Sclerodactyly | |
| HP:0032169 | Severe infection | |
| Occasional (29-5%) | ||
| HP:0001627 | Abnormal heart morphology | |
| HP:0006530 | Abnormal pulmonary interstitial morphology | |
| HP:0011121 | Abnormal skin morphology | |
| HP:0003549 | Abnormality of connective tissue | |
| HP:0000077 | Abnormality of the kidney | |
| HP:0000819 | Diabetes mellitus | |
| HP:0003551 | Difficulty climbing stairs | |
| HP:0009053 | Distal lower limb muscle weakness | |
| HP:0002910 | Elevated circulating hepatic transaminase concentration | |
| HP:0001288 | Gait disturbance | |
| HP:0001882 | Leukopenia | |
| HP:0009763 | Limb pain | |
| HP:0002092 | Pulmonary arterial hypertension | |
| HP:0100324 | Scleroderma | |
| HP:0004269 | Subluxation of the small joints of the hand | |
| HP:0002725 | Systemic lupus erythematosus | |
| HP:0002273 | Tetraparesis | |
| HP:0001873 | Thrombocytopenia | |
| Very rare (<4-1%) | ||
| HP:0001370 | Rheumatoid arthritis | |
Annotation source: 29865091[PMID]_33458584[PMID]_30968571[PMID]
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/206572
- This record as JSON: /data/d/206572.json