raremaprare-disease reference indexOrphadata 2026-06-23 · HPO 2026-09-01
ORPHA:173

Cholera

Type
Disease
Group
Disorder
Inheritance
Not applicable
Age of onset
All ages
Status
active

Cholera is an infectious disease, caused by intestinal infection with <i>Vibrio cholerae</i>, characterized by massive watery diarrhea and severe dehydration that can lead to shock and death if left untreated.

1

Names in Orphadata languages

12 of 12 languages
LangNameSynonyms
enCholera
frCholéra
deCholera
esCólera
itColera
nlCholera
ptCólera
plCholera
csCholera
ukХолера
zh霍乱
trKolera

Definition in:

2

Cross-references

qualifier = Orphanet mapping relation
SourceCodeQualifierICD relationValidation
ICD-10A00.0BTNTspecificvalidated
ICD-10A00.1BTNTspecificvalidated
ICD-10A00.9BTNTspecificvalidated
ICD-111A00Especificvalidated
MONDO0015766Evalidated
MeSHD002771Evalidated
UMLSC0008354Evalidated
GARD6043Evalidated
MedDRA10008631Evalidated

E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.

3

Classification

Preferential parent (Orphanet linearisation):

Parents in the classifications (1):

No children.

4

Genes

0 direct

Orphanet records no gene directly on this code.

5

Prevalence and incidence

13 records
TypeClassValueAreaQualificationValidationSource
Point prevalence<1 / 1 000 000—EuropeClass onlyValidatedWorld Health Organization 2011[OTHER]
Point prevalence<1 / 1 000 000—United StatesClass onlyValidatedWorld Health Organization 2011[OTHER]
Annual incidence<1 / 1 000 000—EuropeClass onlyValidatedEuropean Centre for Disease prevention and Control 2013-2017[OTHER]
Annual incidence<1 / 1 000 000—United KingdomClass onlyValidatedEuropean Centre for Disease prevention and Control 2013-2017[OTHER]
Annual incidence<1 / 1 000 000—GermanyClass onlyValidatedEuropean Centre for Disease prevention and Control 2013-2017[OTHER]
Annual incidence<1 / 1 000 000—AustriaClass onlyValidatedEuropean Centre for Disease prevention and Control 2013-2017[OTHER]
Annual incidence<1 / 1 000 000—BelgiumClass onlyValidatedEuropean Centre for Disease prevention and Control 2013-2017[OTHER]
Annual incidence<1 / 1 000 000—Czech RepublicClass onlyValidatedEuropean Centre for Disease prevention and Control 2013-2017[OTHER]
Annual incidence<1 / 1 000 000—DenmarkClass onlyValidatedEuropean Centre for Disease prevention and Control 2013-2017[OTHER]
Annual incidence<1 / 1 000 000—FranceClass onlyValidatedEuropean Centre for Disease prevention and Control 2013-2017[OTHER]
Annual incidence<1 / 1 000 000—NorwayClass onlyValidatedEuropean Centre for Disease prevention and Control 2013-2017[OTHER]
Annual incidence<1 / 1 000 000—SpainClass onlyValidatedEuropean Centre for Disease prevention and Control 2013-2017[OTHER]
Annual incidence<1 / 1 000 000—SwedenClass onlyValidatedEuropean Centre for Disease prevention and Control 2013-2017[OTHER]

Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.

6

HPO phenotypes

34 annotations · validated 2020-04-01
HPOTerm (as annotated by Orphanet)Diagnostic
Very frequent (99-80%)
HP:0002014Diarrhea
Frequent (79-30%)
HP:0003111Abnormal blood ion concentration
HP:0011036Abnormality of renal excretion
HP:0001941Acidosis
HP:0011037Decreased urine output
HP:0001944Dehydration
HP:0002901Hypocalcemia
HP:0002900Hypokalemia
HP:0002902Hyponatremia
HP:0002615Hypotension
HP:0003394Muscle spasm
HP:0001324Muscle weakness
HP:0001649Tachycardia
HP:0002013Vomiting
Occasional (29-5%)
HP:0032155Abdominal cramps
HP:0002027Abdominal pain
HP:0032448Achlorhydria
HP:0001919Acute kidney injury
HP:0000490Deeply set eye
HP:0002883Hyperventilation
HP:0001943Hypoglycemia
HP:0031274Hypovolemic shock
HP:0000737Irritability
HP:0003128Lactic acidosis
HP:0001254Lethargy
HP:0007185Loss of consciousness
HP:0007517Palmoplantar cutis laxa
HP:0001622Premature birth
HP:0001250Seizure
HP:0005268Spontaneous abortion
HP:0002789Tachypnea
Very rare (<4-1%)
HP:0011951Aspiration pneumonia
HP:0001945Fever
HP:0001297Stroke

Run the differential on the 1 obligate / very frequent terms

Annotation source: 22748592[PMID]_30512613[PMID]_28302312[PMID]

7

Sources for this card