{"orpha":173,"name":"Cholera","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":[],"definition":"Cholera is an infectious disease, caused by intestinal infection with <i>Vibrio cholerae</i>, characterized by massive watery diarrhea and severe dehydration that can lead to shock and death if left untreated.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-173/","orphanet_url":"https://www.orpha.net/en/disease/detail/173","names":{"fr":{"name":"Choléra","definition":"Maladie infectieuse rare due à une infection intestinale par le bacille <i>Vibrio cholerae</i>, caractérisée par une diarrhée aqueuse abondante et une déshydratation sévère qui peuvent entraîner un choc et le décès du patient en l'absence de traitement."},"de":{"name":"Cholera","definition":"Cholera ist eine Infektionskrankheit, die durch eine Darminfektion mit <i>Vibrio cholerae</i> verursacht wird und durch massive wässrige Durchfälle und schwere Dehydrierung gekennzeichnet ist, die unbehandelt zu Schock und Tod führen kann."},"es":{"name":"Cólera","definition":"Es una enfermedad infecciosa, causada por una infección intestinal con <i>Vibrio cholerae</i>, que se caracteriza por una diarrea acuosa masiva y deshidratación grave que puede evolucionar a conmoción y muerte en ausencia de tratamiento."},"it":{"name":"Colera","definition":"Il colera è una malattia infettiva, secondaria a un'infezione intestinale causata dal <i>Vibrio cholerae</i>; è caratterizzata da diarrea acquosa massiva e grave disidratazione che, se non trattate, possono esitare nello shock e nel decesso."},"nl":{"name":"Cholera","definition":"Cholera is een infectieziekte veroorzaakt door intestinale infectie met <i>Vibrio cholerae</i> en gekarakteriseerd door massale waterige diarree en ernstige dehydratie, die kan leiden tot shock en overlijden indien behandeling uitblijft."},"pt":{"name":"Cólera","definition":"A cólera é uma doença infecciosa caracterizada por diarreia grave e vómitos causada pelo <i>Vibrio cholera</i>, um pequeno bacilo Gram-negativo."},"pl":{"name":"Cholera"},"cs":{"name":"Cholera"},"uk":{"name":"Холера","definition":"Cholera is an infectious disease, caused by intestinal infection with <i>Vibrio cholerae</i>, characterized by massive watery diarrhea and severe dehydration that can lead to shock and death if left untreated."},"zh":{"name":"霍乱"},"tr":{"name":"Kolera"}},"xrefs":[{"source":"ICD-10","code":"A00.0","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"A00.1","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"A00.9","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-11","code":"1A00","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"257068234"},{"source":"MONDO","code":"0015766","qualifier":"E","icd_relation":null,"validated":true},{"source":"MeSH","code":"D002771","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0008354","qualifier":"E","icd_relation":null,"validated":true},{"source":"GARD","code":"6043","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10008631","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":68416,"name":"Rare infectious disease"},"parents":[{"orpha":163582,"name":"Rare bacterial infectious disease","classifications":[203]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["All ages"],"prevalence":[{"type":"Point prevalence","qualification":"Class only","class":"<1 / 1 000 000","value":0.0,"area":"Europe","status":"Validated","source":"World Health Organization 2011[OTHER]"},{"type":"Point prevalence","qualification":"Class only","class":"<1 / 1 000 000","value":0.0,"area":"United States","status":"Validated","source":"World Health Organization 2011[OTHER]"},{"type":"Annual incidence","qualification":"Class only","class":"<1 / 1 000 000","value":0.0,"area":"Europe","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Class only","class":"<1 / 1 000 000","value":0.0,"area":"United Kingdom","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Class only","class":"<1 / 1 000 000","value":0.0,"area":"Germany","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Class only","class":"<1 / 1 000 000","value":0.0,"area":"Austria","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Class only","class":"<1 / 1 000 000","value":0.0,"area":"Belgium","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Class only","class":"<1 / 1 000 000","value":0.0,"area":"Czech Republic","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Class only","class":"<1 / 1 000 000","value":0.0,"area":"Denmark","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Class only","class":"<1 / 1 000 000","value":0.0,"area":"France","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Class only","class":"<1 / 1 000 000","value":0.0,"area":"Norway","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Class only","class":"<1 / 1 000 000","value":0.0,"area":"Spain","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Class only","class":"<1 / 1 000 000","value":0.0,"area":"Sweden","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2020-04-01","source":"22748592[PMID]_30512613[PMID]_28302312[PMID]","terms":[{"hpo":"HP:0002014","label":"Diarrhea","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0003111","label":"Abnormal blood ion concentration","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0011036","label":"Abnormality of renal excretion","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001941","label":"Acidosis","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0011037","label":"Decreased urine output","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001944","label":"Dehydration","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002901","label":"Hypocalcemia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002900","label":"Hypokalemia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002902","label":"Hyponatremia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002615","label":"Hypotension","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0003394","label":"Muscle spasm","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001324","label":"Muscle weakness","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001649","label":"Tachycardia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002013","label":"Vomiting","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0032155","label":"Abdominal cramps","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002027","label":"Abdominal pain","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0032448","label":"Achlorhydria","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001919","label":"Acute kidney injury","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000490","label":"Deeply set eye","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002883","label":"Hyperventilation","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001943","label":"Hypoglycemia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0031274","label":"Hypovolemic shock","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000737","label":"Irritability","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0003128","label":"Lactic acidosis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001254","label":"Lethargy","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0007185","label":"Loss of consciousness","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0007517","label":"Palmoplantar cutis laxa","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001622","label":"Premature birth","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001250","label":"Seizure","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0005268","label":"Spontaneous abortion","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002789","label":"Tachypnea","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0011951","label":"Aspiration pneumonia","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001945","label":"Fever","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001297","label":"Stroke","frequency":"Very rare (<4-1%)","criteria":null}]}}