ORPHA:142
Anaplastic thyroid carcinoma
- Type
- Disease
- Group
- Disorder
- Inheritance
- Not applicable
- Age of onset
- Adult, Elderly
- Status
- active
A disorder that represents the ultimate dedifferentiation step of thyroid tumorigenesis and is one of the most severe cancers in humans.
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Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Anaplastic thyroid carcinoma | |
| fr | Cancer anaplasique de la thyroïde | |
| de | Schilddrüsenkarzinom, anaplastisches | |
| es | Carcinoma anaplásico de tiroides | |
| it | Carcinoma anaplasico della tiroide | |
| nl | Anaplastisch schildkliercarcinoom | |
| pt | Cancro anaplásico da tiroide | |
| pl | Rak anaplastyczny tarczycy | |
| cs | Anaplastický karcinom štítné žlázy | |
| uk | Анапластична карцинома щитовидної залози | |
| zh | 甲状腺未分化癌 | |
| tr | Anaplastik tiroid karsinomu |
Definition in:
2
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | C73 | NTBT | attributed | validated |
| ICD-11 | 2D10.3 | E | specific | validated |
| MONDO | 0006468 | E | validated | |
| MONDO | 6468 | E | validated | |
| MeSH | D065646 | E | validated | |
| UMLS | C0238461 | E | validated | |
| GARD | 664 | E | validated | |
| MedDRA | 10002240 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
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Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (1):
- ORPHA:100088Rare thyroid carcinoma
rare endocrine diseases; rare neoplastic diseases
No children.
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Genes
0 directOrphanet records no gene directly on this code.
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Prevalence and incidence
2 records| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Annual incidence | 1-9 / 1 000 000 | 0.17 / 100 000 | Europe | Value and class | Validated | RARECARE surveillance of rare cancers in Europe 2011[OTHER] |
| Point prevalence | 1-9 / 1 000 000 | 0.1 / 100 000 | Europe | Value and class | Validated | European Medicines Agency 2004[OTHER] |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
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HPO phenotypes
23 annotations · validated 2016-06-13| HPO | Term (as annotated by Orphanet) | Diagnostic |
|---|---|---|
| Obligate (100%) | ||
| HP:0011779 | Anaplastic thyroid carcinoma | |
| Very frequent (99-80%) | ||
| HP:0000475 | Broad neck | |
| HP:0000853 | Goiter | |
| HP:0001609 | Hoarse voice | |
| HP:0005994 | Nodular goiter | |
| Frequent (79-30%) | ||
| HP:0002015 | Dysphagia | |
| HP:0004894 | Laryngotracheal stenosis | |
| HP:0002716 | Lymphadenopathy | |
| HP:0100526 | Neoplasm of the lung | |
| HP:0012531 | Pain | |
| HP:0002098 | Respiratory distress | |
| HP:0002781 | Upper airway obstruction | |
| HP:0001605 | Vocal cord paralysis | |
| Occasional (29-5%) | ||
| HP:0011805 | Abnormal skeletal muscle morphology | |
| HP:0012735 | Cough | |
| HP:0001618 | Dysphonia | |
| HP:0002094 | Dyspnea | |
| HP:0002105 | Hemoptysis | |
| HP:0010622 | Neoplasm of the skeletal system | |
| HP:0010307 | Stridor | |
| HP:0001824 | Weight loss | |
| Very rare (<4-1%) | ||
| HP:0100836 | Malignant neoplasm of the central nervous system | |
| HP:0002575 | Tracheoesophageal fistula | |
Run the differential on the 5 obligate / very frequent terms
Annotation source: 11061600[PMID]_22869844[PMID]_11742333[PMID]_3967175[PMID]_9737368[PMID]
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Sources for this card
- Orphanet page: orpha.net/en/disease/detail/142
- This record as JSON: /data/d/142.json