Severe acute respiratory syndrome
Synonyms: SARS · SARS-1
- Type
- Disease
- Group
- Disorder
- Inheritance
- Not applicable
- Age of onset
- All ages
- Status
- active
A rare pulmonary disease induced by SARS-CoV coronavirus infection, with a reported incubation period varying from 2 to 7 days. Patients present flu-like symptoms, including fever, malaise, myalgia, headache, diarrhoea, and rigors. Dry, nonproductive, cough and dyspnea are frequently reported. Severe cases evolve rapidly, progressing to respiratory distress and failure, requiring intensive care. Mortality rate is 10%. The disease appeared in 2002 in southern China, subsequently spreading in 2003 to 26 countries. Reported human-to-human transmission occurred in Toronto (Canada), Hong Kong Special Administrative Region of China, Chinese Taipei, Singapore, and Hanoi (Viet Nam).
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Severe acute respiratory syndrome | SARS · SARS-1 |
| fr | Syndrome respiratoire aigu sévère | SRAS · SRAS-1 |
| de | Schweres akutes respiratorisches Syndrom | SARS · SARS-1 · Schweres akutes Atemwegssyndrom |
| es | Síndrome respiratorio agudo grave | = en |
| it | Sindrome respiratoria acuta grave | = en |
| nl | Ernstig acuut respiratoir syndroom | = en |
| pt | Síndrome de dificuldade respiratória aguda | SARS · SARS-1 · SDRA |
| pl | Zespół ostrej niewydolności oddechowej | SARS · SARS z towarzysząca infekcją koronawirusową · SARS-CoV |
| cs | Akutní respirační koronavirové infekce | = en |
| uk | Тяжкий гострий респіраторний синдром | = en |
| zh | 严重急性呼吸道综合征 | = en |
| tr | Ağır akut solunum sendromu | = en |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | U04 | E | specific | validated |
| ICD-11 | 1D65 | E | specific | validated |
| MONDO | 0005091 | E | validated | |
| MeSH | D045169 | E | validated | |
| UMLS | C1175175 | E | validated | |
| GARD | 9237 | E | validated | |
| MedDRA | 10061982 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (2):
- ORPHA:101944Rare pulmonary disease
rare respiratory diseases - ORPHA:163585Rare viral disease
rare infectious diseases
No children.
Genes
0 directOrphanet records no gene directly on this code.
Prevalence and incidence
2 records| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Point prevalence | Unknown | — | Worldwide | Class only | Not yet validated | ORPHANET |
| Annual incidence | <1 / 1 000 000 | — | Europe | Class only | Validated | European Centre for Disease prevention and Control 2011[OTHER] |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
HPO phenotypes
16 annotations · validated 2019-06-20| HPO | Term (as annotated by Orphanet) | Diagnostic |
|---|---|---|
| Very frequent (99-80%) | ||
| HP:0012735 | Cough | |
| Frequent (79-30%) | ||
| HP:0002094 | Dyspnea | |
| HP:0001945 | Fever | |
| HP:0002315 | Headache | |
| HP:0002721 | Immunodeficiency | |
| HP:0003326 | Myalgia | |
| HP:0002098 | Respiratory distress | |
| Occasional (29-5%) | ||
| HP:0001626 | Abnormality of the cardiovascular system | |
| HP:0011949 | Acute infectious pneumonia | |
| HP:0006528 | Chronic lung disease | |
| HP:0000819 | Diabetes mellitus | |
| HP:0012418 | Hypoxemia | |
| HP:0002664 | Neoplasm | |
| HP:0025439 | Pharyngitis | |
| HP:0004887 | Respiratory failure requiring assisted ventilation | |
| Very rare (<4-1%) | ||
| HP:0001919 | Acute kidney injury | |
Run the differential on the 1 obligate / very frequent terms
Annotation source: 30505188[PMID]_30623094[PMID]_25270030[PMID]_27195607[PMID]
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/140896
- This record as JSON: /data/d/140896.json