{"orpha":140896,"name":"Severe acute respiratory syndrome","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":["SARS","SARS-1"],"definition":"A rare pulmonary disease induced by SARS-CoV coronavirus infection, with a reported incubation period varying from 2 to 7 days. Patients present flu-like symptoms, including fever, malaise, myalgia, headache, diarrhoea, and rigors. Dry, nonproductive, cough and dyspnea are frequently reported. Severe cases evolve rapidly, progressing to respiratory distress and failure, requiring intensive care. Mortality rate is 10%. The disease appeared in 2002 in southern China, subsequently spreading in 2003 to 26 countries. Reported human-to-human transmission occurred in Toronto (Canada), Hong Kong Special Administrative Region of China, Chinese Taipei, Singapore, and Hanoi (Viet Nam).","note":null,"url":"https://raremap.alftech.space/d/ORPHA-140896/","orphanet_url":"https://www.orpha.net/en/disease/detail/140896","names":{"fr":{"name":"Syndrome respiratoire aigu sévère","synonyms":["SRAS","SRAS-1"],"definition":"Une maladie pulmonaire rare induite par une infection à coronavirus du SRAS-CoV, dont la période d'incubation varie de 2 à 7 jours. Les patients présentent des symptômes de type grippal, notamment de la fièvre, des malaises, des myalgies, des maux de tête, des diarrhées et des tremblements. Une toux sèche et non productive et une dyspnée sont fréquemment signalées. Les cas graves évoluent rapidement, progressant vers la détresse et l'insuffisance respiratoire, nécessitant des soins intensifs. Le taux de mortalité est de 10 %. La maladie est apparue en 2002 dans le sud de la Chine, puis s'est étendue en 2003 dans 26 pays. Des cas de transmission interhumaine ont été signalés à Toronto (Canada), dans la Région administrative spéciale de Hong Kong (Chine), à Taipei, à Singapour et à Hanoï (Viet Nam)."},"de":{"name":"Schweres akutes respiratorisches Syndrom","synonyms":["SARS","SARS-1","Schweres akutes Atemwegssyndrom"],"definition":"Eine seltene Lungenerkrankung, die durch eine Infektion mit dem Coronavirus SARS-CoV ausgelöst wird. Die Inkubationszeit beträgt 2-7 Tage. Die Patienten zeigen grippeähnliche Symptome wie Fieber, Unwohlsein, Myalgien, Kopfschmerzen, Durchfall und Rigor. Häufig wird von trockenem, nicht produktivem Husten und Atemnot berichtet. Schwere Fälle entwickeln sich rasch und führen zu Atemnot und Atemversagen, so dass eine intensivmedizinische Behandlung erforderlich ist. Die Sterblichkeitsrate liegt bei 10%. Die Krankheit trat 2002 in Südchina auf und breitete sich 2003 auf 26 Länder aus. Übertragungen von Mensch zu Mensch wurden aus Toronto (Kanada), der Sonderverwaltungszone Hongkong (China), Chinesisch-Taipeh, Singapur und Hanoi (Vietnam) gemeldet."},"es":{"name":"Síndrome respiratorio agudo grave","synonyms":["SARS","SARS-1"],"definition":"Es una enfermedad pulmonar poco frecuente inducida por la infección por el coronavirus SARS-CoV, con un período de incubación variable de 2 a 7 días. Los pacientes se presentan con síntomas similares a la gripe, incluyendo fiebre, malestar, mialgia, cefalea, diarrea y escalofríos. Con frecuencia se describe tos seca no productiva y disnea. Los casos graves evolucionan rápidamente a distrés e insuficiencia respiratoria, requiriendo de cuidados intensivos. La tasa de mortalidad es del 10%. La enfermedad apareció en 2002 en el sur de China, propagándose en 2003 a 26 países. Se describió transmisión entre humanos en Toronto (Canadá), la Región Administrativa Especial de Hong Kong de China, China Taipéi, Singapur y Hanoi (Vietnam)."},"it":{"name":"Sindrome respiratoria acuta grave","synonyms":["SARS","SARS-1"],"definition":"Si tratta di una pneumopatia rara causata dall'infezione da coronavirus SARS-CoV, che ha un periodo di incubazione compreso tra 2 e 7 giorni. I pazienti presentano sintomi simil-influenzali che comprendono la febbre, il malessere, la mialgia, la cefalea, la diarrea e i brividi. Spesso i pazienti presentano tosse secca non produttiva e dispnea. Nei casi più gravi, la malattia progredisce rapidamente verso il distress respiratorio e l'insufficienza respiratoria, che richiedono cure intensive. Il tasso di mortalità è del 10%. La malattia è comparsa per la prima volta nella Cina meridionale nel 2002, e successivamente nel 2003, diffondendosi in altri 26 paesi. Sono stati documentati casi di trasmissione da uomo a uomo a Toronto (Canada), nella Regione Amministrativa Speciale Cinese di Hong-Kong, a Taiwan, Singapore e Hanoi (Vietnam)."},"nl":{"name":"Ernstig acuut respiratoir syndroom","synonyms":["SARS","SARS-1"],"definition":"Een zeldzame longaandoening, geïnduceerd door infectie met coronavirus SARS-CoV en met een gerapporteerde incubatieperiode die varieert van 2 tot 7 dagen. Patiënten vertonen griepachtige symptomen, waaronder koorts, malaise, myalgie, hoofdpijn, diarree, en koude rillingen. Droge, niet-productieve hoest en dyspneu worden vaak gerapporteerd. Ernstige gevallen evolueren snel, met progressie tot ademnood en respiratoir falen, en vereisen intensieve zorg. De mortaliteit bedraagt 10%. De ziekte verscheen in 2002 in Zuid-China, om vervolgens in 2003 te verspreiden naar 26 landen. Transmissie tussen mensen werd gerapporteerd in Toronto (Canada), Speciale Bestuurlijke Regio Hongkong van de Volksrepubliek China, Chinees Taipei, Singapore, en Hanoi (Vietnam)."},"pt":{"name":"Síndrome de dificuldade respiratória aguda","synonyms":["SARS","SARS-1","SDRA"],"definition":"Uma doença pulmonar rara causada pela infecção por coronavirus SARS-CoV, apresenta um período estimado de incubação de 2 a 7 dias. Os doentes apresentam sintomas semelhantes à gripe, incluindo febre, mal estar, mialgias, doe de cabeça, diarreia e arrepios. Tosse seca, não produtiva e dispneia são frequentemente relatadas. Nos casos mais graves, a evolução é rápida e progride para dificuldade e falência respiratória, implicando o recurso aos cuidados intensivos. A doença surgiu em 2002, no sudoeste da China, e subsquentemente disseminou-se, em 2003, a 26 países. Em Toronto (Canada), Região Administrativa Especial de Hong Kong Chinesa, Taipei Chinesa, Singapura e Hanoi (Vietnam) houve descrição de casos cuja transmissão ocorreu entre Humanos."},"pl":{"name":"Zespół ostrej niewydolności oddechowej","synonyms":["SARS","SARS z towarzysząca infekcją koronawirusową","SARS-CoV"]},"cs":{"name":"Akutní respirační koronavirové infekce","synonyms":["SARS","SARS-1"]},"uk":{"name":"Тяжкий гострий респіраторний синдром","synonyms":["SARS","SARS-1"],"definition":"A rare pulmonary disease induced by SARS-CoV coronavirus infection, with a reported incubation period varying from 2 to 7 days. Patients present flu-like symptoms, including fever, malaise, myalgia, headache, diarrhoea, and rigors. Dry, nonproductive, cough and dyspnea are frequently reported. Severe cases evolve rapidly, progressing to respiratory distress and failure, requiring intensive care. Mortality rate is 10%. The disease appeared in 2002 in southern China, subsequently spreading in 2003 to 26 countries. Reported human-to-human transmission occurred in Toronto (Canada), Hong Kong Special Administrative Region of China, Chinese Taipei, Singapore, and Hanoi (Viet Nam)."},"zh":{"name":"严重急性呼吸道综合征","synonyms":["SARS","SARS-1"],"definition":"一种由SARS-CoV冠状病毒感染引起的罕见肺部疾病，据报道潜伏期为2至7天。患者呈流感样症状，包括发热、全身乏力、肌痛、头痛、腹泻和寒颤。干燥，劳动力丧失，咳嗽和呼吸困难为常见报道。严重病例进展迅速，发展为呼吸窘迫和衰竭，需要重症监护。死亡率为10%。该疾病于2002年在中国南方出现，随后于2003年传播至26个国家。人传人发生在多伦多（加拿大）、中国香港特别行政区、中国台北、新加坡和河内（越南）。"},"tr":{"name":"Ağır akut solunum sendromu","synonyms":["SARS","SARS-1"]}},"xrefs":[{"source":"ICD-10","code":"U04","qualifier":"E","icd_relation":"specific","validated":true},{"source":"ICD-11","code":"1D65","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"652944603"},{"source":"MONDO","code":"0005091","qualifier":"E","icd_relation":null,"validated":true},{"source":"MeSH","code":"D045169","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C1175175","qualifier":"E","icd_relation":null,"validated":true},{"source":"GARD","code":"9237","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10061982","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":97955,"name":"Rare respiratory disease"},"parents":[{"orpha":101944,"name":"Rare pulmonary disease","classifications":[184]},{"orpha":163585,"name":"Rare viral disease","classifications":[203]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["All ages"],"prevalence":[{"type":"Point prevalence","qualification":"Class only","class":"Unknown","value":0.0,"area":"Worldwide","status":"Not yet validated","source":"ORPHANET"},{"type":"Annual incidence","qualification":"Class only","class":"<1 / 1 000 000","value":0.0,"area":"Europe","status":"Validated","source":"European Centre for Disease prevention and Control 2011[OTHER]"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2019-06-20","source":"30505188[PMID]_30623094[PMID]_25270030[PMID]_27195607[PMID]","terms":[{"hpo":"HP:0012735","label":"Cough","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0002094","label":"Dyspnea","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001945","label":"Fever","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002315","label":"Headache","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002721","label":"Immunodeficiency","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0003326","label":"Myalgia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002098","label":"Respiratory distress","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001626","label":"Abnormality of the cardiovascular system","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0011949","label":"Acute infectious pneumonia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0006528","label":"Chronic lung disease","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000819","label":"Diabetes mellitus","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0012418","label":"Hypoxemia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002664","label":"Neoplasm","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0025439","label":"Pharyngitis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0004887","label":"Respiratory failure requiring assisted ventilation","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001919","label":"Acute kidney injury","frequency":"Very rare (<4-1%)","criteria":null}]}}