ORPHA:1332
Medullary thyroid carcinoma
Synonyms: MTC
- Type
- Disease
- Group
- Disorder
- Inheritance
- Not applicable
- Age of onset
- Adult
- Status
- active
Medullary thyroid carcinoma (MTC) is developed from thyroid C cells that secrete calcitonin (CT).
1
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Medullary thyroid carcinoma | MTC |
| fr | Cancer médullaire de la thyroïde | = en |
| de | Schilddrüsenkarzinom, medulläres | |
| es | Carcinoma medular de tiroides | = en |
| it | Carcinoma midollare della tiroide | = en |
| nl | Medullair schildkliercarcinoom | = en |
| pt | Cancro medular da tiroide | |
| pl | Rak rdzeniasty tarczycy | = en |
| cs | Medulární karcinom štítné žlázy | = en |
| uk | Медулярна карцинома щитоподібної залози | = en |
| zh | 甲状腺髓样癌 | = en |
| tr | Medüller tiroid karsinomu | = en |
Definition in:
2
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | C73 | NTBT | attributed | validated |
| ICD-11 | 2D10.4 | E | specific | validated |
| MONDO | 0015277 | E | validated | |
| MeSH | C536914 | E | validated | |
| UMLS | C0238462 | E | validated | |
| GARD | 7004 | E | validated | |
| MedDRA | 10027101 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
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Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (1):
- ORPHA:100088Rare thyroid carcinoma
rare endocrine diseases; rare neoplastic diseases
No children.
4
Genes
0 directOrphanet records no gene directly on this code.
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Prevalence and incidence
3 records| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Point prevalence | 1-9 / 100 000 | 5 / 100 000 | Europe | Value and class | Validated | European Medicines Agency 2018[OTHER] |
| Annual incidence | 1-9 / 1 000 000 | 0.17 / 100 000 | United States | Value and class | Validated | 21186939[PMID]_National Cancer OTHERitute 1992-2006[OTHER] |
| Annual incidence | 1-9 / 1 000 000 | 0.22 / 100 000 | Europe | Value and class | Validated | RARECARE surveillance of rare cancers in Europe 2011[OTHER] |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
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HPO phenotypes
14 annotations · validated 2016-06-13| HPO | Term (as annotated by Orphanet) | Diagnostic |
|---|---|---|
| Obligate (100%) | ||
| HP:0002865 | Medullary thyroid carcinoma | |
| Very frequent (99-80%) | ||
| HP:0003528 | Elevated calcitonin | |
| HP:0005994 | Nodular goiter | |
| Frequent (79-30%) | ||
| HP:0002014 | Diarrhea | |
| HP:0002015 | Dysphagia | |
| HP:0000975 | Hyperhidrosis | |
| HP:0002716 | Lymphadenopathy | |
| Occasional (29-5%) | ||
| HP:0030146 | Abnormal liver parenchyma morphology | |
| HP:0001618 | Dysphonia | |
| HP:0100526 | Neoplasm of the lung | |
| HP:0010622 | Neoplasm of the skeletal system | |
| HP:0002666 | Pheochromocytoma | |
| HP:0008200 | Primary hyperparathyroidism | |
| HP:0001824 | Weight loss | |
Run the differential on the 3 obligate / very frequent terms
Annotation source: 25810047[PMID]_23744408[PMID]_21346073[PMID]_21717441[PMID]_24261394[PMID]_24942936[PMID]_25490273[PMID]_22170709[PMID]_22162466[PMID]_20943788[PMID]
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Sources for this card
- Orphanet page: orpha.net/en/disease/detail/1332
- This record as JSON: /data/d/1332.json