ORPHA:1304
Brucellosis
- Type
- Disease
- Group
- Disorder
- Inheritance
- Not applicable
- Age of onset
- All ages
- Status
- active
Brucellosis is an anthropozoonotic infection, endemic in the Mediterranean region, the Middle East, Latin America and parts of Asia and Africa, that is caused by gram-negative coccobacilli of the genus <i>Brucella</i> transmitted through consumption of unpasteurized dairy products or through direct contact with infected animals, placentas or aborted fetuses. Brucellosis is characterized by fever, fatigue, malaise, headache, anorexia, weight loss, sweating, osteomuscular pain (joint and lumbar pain), and arthritis.
1
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Brucellosis | |
| fr | Brucellose | |
| de | Brucellose | |
| es | Brucelosis | |
| it | Brucellosi | |
| nl | Brucellose | Maltakoorts |
| pt | Brucelose | |
| pl | Brucelloza | |
| cs | Brucelóza | |
| uk | Бруцельоз | |
| zh | 布鲁杆菌病 | |
| tr | Bruselloz |
Definition in:
2
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | A23.0 | BTNT | specific | validated |
| ICD-10 | A23.1 | BTNT | specific | validated |
| ICD-10 | A23.2 | BTNT | specific | validated |
| ICD-10 | A23.3 | BTNT | specific | validated |
| ICD-10 | A23.8 | BTNT | specific | validated |
| ICD-10 | A23.9 | BTNT | specific | validated |
| ICD-11 | 1B95 | E | specific | validated |
| MONDO | 0005683 | E | validated | |
| MeSH | D002006 | E | validated | |
| UMLS | C0006309 | E | validated | |
| GARD | 5966 | E | validated | |
| MedDRA | 10006500 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
3
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (1):
- ORPHA:163582Rare bacterial infectious disease
rare infectious diseases
No children.
4
Genes
0 directOrphanet records no gene directly on this code.
5
Prevalence and incidence
25 records| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Annual incidence | <1 / 1 000 000 | 0.09 / 100 000 | Europe | Value and class | Validated | European Centre for Disease prevention and Control 2013-2017[OTHER] |
| Annual incidence | 1-9 / 1 000 000 | 0.11 / 100 000 | Bulgaria | Value and class | Validated | European Centre for Disease prevention and Control 2013-2016[OTHER] |
| Annual incidence | <1 / 1 000 000 | 0.02 / 100 000 | Croatia | Value and class | Validated | European Centre for Disease prevention and Control 2013-2016[OTHER] |
| Annual incidence | <1 / 1 000 000 | 0.004 / 100 000 | Czech Republic | Value and class | Validated | European Centre for Disease prevention and Control 2013-2016[OTHER] |
| Annual incidence | <1 / 1 000 000 | 0.008 / 100 000 | Finland | Value and class | Validated | European Centre for Disease prevention and Control 2013-2016[OTHER] |
| Annual incidence | <1 / 1 000 000 | 0.04 / 100 000 | Austria | Value and class | Validated | European Centre for Disease prevention and Control 2013-2017[OTHER] |
| Annual incidence | <1 / 1 000 000 | 0.05 / 100 000 | Germany | Value and class | Validated | European Centre for Disease prevention and Control 2013-2017[OTHER] |
| Annual incidence | 1-9 / 100 000 | 1.13 / 100 000 | Greece | Value and class | Validated | European Centre for Disease prevention and Control 2013-2017[OTHER] |
| Annual incidence | <1 / 1 000 000 | 0.03 / 100 000 | Ireland | Value and class | Validated | European Centre for Disease prevention and Control 2013-2017[OTHER] |
| Annual incidence | 1-9 / 1 000 000 | 0.22 / 100 000 | Italy | Value and class | Validated | European Centre for Disease prevention and Control 2013-2017[OTHER] |
| Annual incidence | <1 / 1 000 000 | 0.01 / 100 000 | Lithuania | Value and class | Validated | European Centre for Disease prevention and Control 2013-2017[OTHER] |
| Annual incidence | <1 / 1 000 000 | 0.03 / 100 000 | Luxembourg | Value and class | Validated | European Centre for Disease prevention and Control 2013-2017[OTHER] |
| Annual incidence | <1 / 1 000 000 | 0.05 / 100 000 | Malta | Value and class | Validated | European Centre for Disease prevention and Control 2013-2017[OTHER] |
| Annual incidence | <1 / 1 000 000 | 0.05 / 100 000 | Norway | Value and class | Validated | European Centre for Disease prevention and Control 2013-2017[OTHER] |
| Annual incidence | 1-9 / 1 000 000 | 0.35 / 100 000 | Portugal | Value and class | Validated | European Centre for Disease prevention and Control 2013-2017[OTHER] |
| Annual incidence | 1-9 / 1 000 000 | 0.12 / 100 000 | Spain | Value and class | Validated | European Centre for Disease prevention and Control 2013-2017[OTHER] |
| Annual incidence | 1-9 / 1 000 000 | 0.15 / 100 000 | Sweden | Value and class | Validated | European Centre for Disease prevention and Control 2013-2017[OTHER] |
| Annual incidence | <1 / 1 000 000 | 0.03 / 100 000 | France | Value and class | Validated | 27717526[PMID]_European Centre for Disease prevention and Control 2013-2017[OTHER] |
| Annual incidence | <1 / 1 000 000 | 0.02 / 100 000 | United Kingdom | Value and class | Validated | European Centre for Disease prevention and Control 2013-2016[OTHER] |
| Annual incidence | <1 / 1 000 000 | 0.01 / 100 000 | Romania | Value and class | Validated | European Centre for Disease prevention and Control 2013-2016[OTHER] |
| Annual incidence | <1 / 1 000 000 | 0.02 / 100 000 | Slovakia | Value and class | Validated | European Centre for Disease prevention and Control 2013-2016[OTHER] |
| Annual incidence | <1 / 1 000 000 | 0.02 / 100 000 | Slovenia | Value and class | Validated | European Centre for Disease prevention and Control 2013-2016[OTHER] |
| Annual incidence | <1 / 1 000 000 | 0.02 / 100 000 | Netherlands | Value and class | Validated | European Centre for Disease prevention and Control 2013-2016[OTHER] |
| Annual incidence | <1 / 1 000 000 | 0.01 / 100 000 | Poland | Value and class | Validated | European Centre for Disease prevention and Control 2013-2016[OTHER] |
| Annual incidence | <1 / 1 000 000 | 0.04 / 100 000 | Belgium | Value and class | Validated | European Centre for Disease prevention and Control 2013-2016[OTHER] |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
6
HPO phenotypes
77 annotations · validated 2020-04-01| HPO | Term (as annotated by Orphanet) | Diagnostic |
|---|---|---|
| Very frequent (99-80%) | ||
| HP:0001392 | Abnormality of the liver | |
| Frequent (79-30%) | ||
| HP:0025155 | Abnormality of hepatobiliary system physiology | |
| HP:0011024 | Abnormality of the gastrointestinal tract | |
| HP:0001903 | Anemia | |
| HP:0002039 | Anorexia | |
| HP:0002829 | Arthralgia | |
| HP:0001369 | Arthritis | |
| HP:0025406 | Asthenia | |
| HP:0011227 | Elevated circulating C-reactive protein concentration | |
| HP:0003565 | Elevated erythrocyte sedimentation rate | |
| HP:0012378 | Fatigue | |
| HP:0001945 | Fever | |
| HP:0002240 | Hepatomegaly | |
| HP:0000975 | Hyperhidrosis | |
| HP:0003237 | Increased circulating IgG level | |
| HP:0001882 | Leukopenia | |
| HP:0002018 | Nausea | |
| HP:0003095 | Septic arthritis | |
| HP:0001744 | Splenomegaly | |
| HP:0001824 | Weight loss | |
| Occasional (29-5%) | ||
| HP:0002027 | Abdominal pain | |
| HP:0012252 | Abnormal respiratory system morphology | |
| HP:0005561 | Abnormality of bone marrow cell morphology | |
| HP:0000119 | Abnormality of the genitourinary system | |
| HP:0000707 | Abnormality of the nervous system | |
| HP:0410008 | Abnormality of the peripheral nervous system | |
| HP:0000951 | Abnormality of the skin | |
| HP:0012387 | Bronchitis | |
| HP:0025143 | Chills | |
| HP:0025245 | Cutaneous cyst | |
| HP:0000716 | Depression | |
| HP:0000031 | Epididymitis | |
| HP:0030350 | Erythematous papule | |
| HP:0001508 | Failure to thrive | |
| HP:0000099 | Glomerulonephritis | |
| HP:0032252 | Granuloma | |
| HP:0002315 | Headache | |
| HP:0008843 | Hip osteoarthritis | |
| HP:0001971 | Hypersplenism | |
| HP:0100326 | Immunologic hypersensitivity | |
| HP:0003496 | Increased circulating IgM level | |
| HP:0001974 | Increased total leukocyte count | |
| HP:0005086 | Knee osteoarthritis | |
| HP:0100523 | Liver abscess | |
| HP:0002716 | Lymphadenopathy | |
| HP:0002011 | Morphological central nervous system abnormality | |
| HP:0100796 | Orchitis | |
| HP:0002754 | Osteomyelitis | |
| HP:0009830 | Peripheral neuropathy | |
| HP:0002202 | Pleural effusion | |
| HP:0002090 | Pneumonia | |
| HP:0001622 | Premature birth | |
| HP:0000979 | Purpura | |
| HP:0002923 | Rheumatoid factor positive | |
| HP:0012317 | Sacroiliac arthritis | |
| HP:0001518 | Small for gestational age | |
| HP:0005268 | Spontaneous abortion | |
| HP:0001873 | Thrombocytopenia | |
| HP:0002013 | Vomiting | |
| Very rare (<4-1%) | ||
| HP:0001646 | Abnormal aortic valve morphology | |
| HP:0031910 | Abnormal cranial nerve physiology | |
| HP:0001626 | Abnormality of the cardiovascular system | |
| HP:0012122 | Anterior uveitis | |
| HP:0012089 | Arteritis | |
| HP:0000708 | Atypical behavior | |
| HP:0002072 | Chorea | |
| HP:0012424 | Chorioretinitis | |
| HP:0100584 | Endocarditis | |
| HP:0002383 | Infectious encephalitis | |
| HP:0032620 | Intrarenal abscess | |
| HP:0025044 | Lung abscess | |
| HP:0012819 | Myocarditis | |
| HP:0001701 | Pericarditis | |
| HP:0030250 | Pulmonary granulomatosis | |
| HP:0001894 | Thrombocytosis | |
| HP:0004418 | Thrombophlebitis | |
| HP:0002326 | Transient ischemic attack | |
Run the differential on the 1 obligate / very frequent terms
Annotation source: 18045560[PMID]_29610436[PMID]
7
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/1304
- This record as JSON: /data/d/1304.json