{"orpha":1304,"name":"Brucellosis","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":[],"definition":"Brucellosis is an anthropozoonotic infection, endemic in the Mediterranean region, the Middle East, Latin America and parts of Asia and Africa, that is caused by gram-negative coccobacilli of the genus <i>Brucella</i> transmitted through consumption of unpasteurized dairy products or through direct contact with infected animals, placentas or aborted fetuses. Brucellosis is characterized by fever, fatigue, malaise, headache, anorexia, weight loss, sweating, osteomuscular pain (joint and lumbar pain), and arthritis.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-1304/","orphanet_url":"https://www.orpha.net/en/disease/detail/1304","names":{"fr":{"name":"Brucellose","definition":"La brucellose est une infection anthropozoonotique, endémique dans la région méditerranéenne, le Moyen-Orient, l'Amérique latine et des régions d'Asie et d'Afrique. Elle est due à des coccobacilles gram-négatives du genre <i>Brucella</i>, transmises par la consommation de produits laitiers non pasteurisés, ou par contact direct avec des animaux, des placentas ou des foetus avortés infectés. La brucellose se caractérise par une fièvre, une fatigue, un malaise, une céphalée, une anorexie, une perte de poids, des sueurs, une douleur ostéo-musculaire (douleur articulaire et lombaire) et une arthrite."},"de":{"name":"Brucellose"},"es":{"name":"Brucelosis","definition":"La brucelosis es una infección antropozoonótica, endémica en la región del Mediterráneo, Medio Oriente, América Latina y partes de Asia y África, causada por cocobacilos gramnegativos del género <i>Brucella</i>, transmitida por el consumo de productos lácteos no pasteurizados o por contacto directo con animales, placentas o fetos abortados infectados. La brucelosis se caracteriza por fiebre, cansancio, malestar general, cefalea, anorexia, pérdida de peso, sudoración, dolor osteomuscular (dolor articular y lumbar) y artritis."},"it":{"name":"Brucellosi"},"nl":{"name":"Brucellose","synonyms":["Maltakoorts"],"definition":"Brucellose is een antropozoönotische infectie, endemisch in het Middellandse Zeegebied, het Midden-Oosten, Latijns-Amerika en delen van Azië en Afrika, die veroorzaakt wordt door gramnegatieve coccobacillen van het genus <i>Brucella</i>, overgedragen door de consumptie van ongepasteuriseerde zuivelproducten of door direct contact met besmette dieren, placenta's of geaborteerde foetussen. Brucellose wordt gekenmerkt door koorts, vermoeidheid, malaise, hoofdpijn, anorexia, gewichtsverlies, zweten, osteomusculaire pijn (gewrichts- en lage rugpijn), en artritis."},"pt":{"name":"Brucelose"},"pl":{"name":"Brucelloza"},"cs":{"name":"Brucelóza"},"uk":{"name":"Бруцельоз","definition":"Brucellosis is an anthropozoonotic infection, endemic in the Mediterranean region, the Middle East, Latin America and parts of Asia and Africa, that is caused by gram-negative coccobacilli of the genus <i>Brucella</i> transmitted through consumption of unpasteurized dairy products or through direct contact with infected animals, placentas or aborted fetuses. Brucellosis is characterized by fever, fatigue, malaise, headache, anorexia, weight loss, sweating, osteomuscular pain (joint and lumbar pain), and arthritis."},"zh":{"name":"布鲁杆菌病"},"tr":{"name":"Bruselloz"}},"xrefs":[{"source":"ICD-10","code":"A23.0","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"A23.1","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"A23.2","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"A23.3","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"A23.8","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"A23.9","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-11","code":"1B95","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"730510331"},{"source":"MONDO","code":"0005683","qualifier":"E","icd_relation":null,"validated":true},{"source":"MeSH","code":"D002006","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0006309","qualifier":"E","icd_relation":null,"validated":true},{"source":"GARD","code":"5966","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10006500","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":68416,"name":"Rare infectious disease"},"parents":[{"orpha":163582,"name":"Rare bacterial infectious disease","classifications":[203]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["All ages"],"prevalence":[{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.09,"area":"Europe","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.11,"area":"Bulgaria","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2016[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.02,"area":"Croatia","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2016[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.004,"area":"Czech Republic","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2016[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.008,"area":"Finland","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2016[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.04,"area":"Austria","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.05,"area":"Germany","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":1.13,"area":"Greece","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.03,"area":"Ireland","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.22,"area":"Italy","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.01,"area":"Lithuania","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.03,"area":"Luxembourg","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.05,"area":"Malta","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.05,"area":"Norway","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.35,"area":"Portugal","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.12,"area":"Spain","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.15,"area":"Sweden","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.03,"area":"France","status":"Validated","source":"27717526[PMID]_European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.02,"area":"United Kingdom","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2016[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.01,"area":"Romania","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2016[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.02,"area":"Slovakia","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2016[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.02,"area":"Slovenia","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2016[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.02,"area":"Netherlands","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2016[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.01,"area":"Poland","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2016[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.04,"area":"Belgium","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2016[OTHER]"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2020-04-01","source":"18045560[PMID]_29610436[PMID]","terms":[{"hpo":"HP:0001392","label":"Abnormality of the liver","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0025155","label":"Abnormality of hepatobiliary system physiology","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0011024","label":"Abnormality of the gastrointestinal tract","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001903","label":"Anemia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002039","label":"Anorexia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002829","label":"Arthralgia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001369","label":"Arthritis","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0025406","label":"Asthenia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0011227","label":"Elevated circulating C-reactive protein concentration","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0003565","label":"Elevated erythrocyte sedimentation rate","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0012378","label":"Fatigue","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001945","label":"Fever","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002240","label":"Hepatomegaly","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000975","label":"Hyperhidrosis","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0003237","label":"Increased circulating IgG level","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001882","label":"Leukopenia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002018","label":"Nausea","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0003095","label":"Septic arthritis","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001744","label":"Splenomegaly","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001824","label":"Weight loss","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002027","label":"Abdominal pain","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0012252","label":"Abnormal respiratory system morphology","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0005561","label":"Abnormality of bone marrow cell morphology","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000119","label":"Abnormality of the genitourinary system","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000707","label":"Abnormality of the nervous system","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0410008","label":"Abnormality of the peripheral nervous system","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000951","label":"Abnormality of the skin","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0012387","label":"Bronchitis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0025143","label":"Chills","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0025245","label":"Cutaneous cyst","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000716","label":"Depression","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000031","label":"Epididymitis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0030350","label":"Erythematous papule","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001508","label":"Failure to thrive","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000099","label":"Glomerulonephritis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0032252","label":"Granuloma","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002315","label":"Headache","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0008843","label":"Hip osteoarthritis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001971","label":"Hypersplenism","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0100326","label":"Immunologic hypersensitivity","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0003496","label":"Increased circulating IgM level","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001974","label":"Increased total leukocyte count","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0005086","label":"Knee osteoarthritis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0100523","label":"Liver abscess","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002716","label":"Lymphadenopathy","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002011","label":"Morphological central nervous system abnormality","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0100796","label":"Orchitis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002754","label":"Osteomyelitis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0009830","label":"Peripheral neuropathy","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002202","label":"Pleural effusion","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002090","label":"Pneumonia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001622","label":"Premature birth","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000979","label":"Purpura","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002923","label":"Rheumatoid factor positive","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0012317","label":"Sacroiliac arthritis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001518","label":"Small for gestational age","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0005268","label":"Spontaneous abortion","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001873","label":"Thrombocytopenia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002013","label":"Vomiting","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001646","label":"Abnormal aortic valve morphology","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0031910","label":"Abnormal cranial nerve physiology","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001626","label":"Abnormality of the cardiovascular system","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0012122","label":"Anterior uveitis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0012089","label":"Arteritis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0000708","label":"Atypical behavior","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0002072","label":"Chorea","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0012424","label":"Chorioretinitis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0100584","label":"Endocarditis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0002383","label":"Infectious encephalitis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0032620","label":"Intrarenal abscess","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0025044","label":"Lung abscess","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0012819","label":"Myocarditis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001701","label":"Pericarditis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0030250","label":"Pulmonary granulomatosis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001894","label":"Thrombocytosis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0004418","label":"Thrombophlebitis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0002326","label":"Transient ischemic attack","frequency":"Very rare (<4-1%)","criteria":null}]}}