Acute myeloid leukemia and myelodysplastic syndromes related to alkylating agent
Synonyms: AML and myelodysplastic syndromes related to alkylating agent
- Type
- Disease
- Group
- Disorder
- Status
- active
A subgroup of therapy-related myeloid neoplasms (t-MN), associated with a treatment of an unrelated neoplastic or autoimmune disease with cytotoxic agents, like cyclophosphamid, platins, melphalan and others. The neoplastic cells typically harbor unbalanced aberrations of chromosomes 5 and 7 (monosomy 5/del(5q) and monosomy 7/del(7q)) or a complex karyotype. It usually presents with multilineage dysplasia and cytopenias 5-10 years after exposure, with symptoms related to the degree of bone marrow failure and the corresponding cytopenia (fatigue, bleeding and bruising, recurrent infections, bone pain).
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Acute myeloid leukemia and myelodysplastic syndromes related to alkylating agent | AML and myelodysplastic syndromes related to alkylating agent |
| fr | Leucémie aiguë myéloïde et syndromes myélodysplasiques liés aux agents alkylants | |
| de | Akute myeloische Leukämie und myelodysplastische Syndrome durch alkylierende Agenzien | AML und MDS durch alkylierende Agenzien |
| es | Leucemia mieloide aguda y síndromes mielodisplásicos relacionados con agentes alquilantes | LMA y síndromes mielodisplásicos asociados a agentes alquilantes |
| it | Leucemia mieloide acuta e sindromi mielodisplastiche correlate ad un agente alchilante | AML e sindromi mielodisplastiche associate ad un agente alchilante |
| nl | Acute myeloïde leukemie en myelodysplastische syndromen gerelateerd aan alkylerend middel | AML en myelodysplastische syndromen gerelateerd aan alkylerend middel |
| pt | Leucemia mielóide aguda e síndromes mielodisplásticos relacionados com agentes alquilantes | |
| pl | Ostra białaczka szpikowa i zespoły mielodysplastyczne związane z czynnikiem alkilującym | AML i zespoły mielodysplastyczne związane z czynnikiem alkilującym |
| cs | Akutní myeloidní leukémie a myelodysplastický syndrom související s alkylačním činidlem | AML a myelodysplastický syndrom související s alkylačním činidlem |
| uk | Гострий мієлоїдний лейкоз та мієлодиспластичні синдроми, повязані з алкілуючим агентом | ГМЛ та мієлодиспластичні синдроми, повязані з алкілуючим агентом |
| zh | 烷化剂相关急性髓系白血病及骨髓增生异常综合征 | 与烷化剂相关的急性髓系白血病和骨髓增生异常综合征 |
| tr | Akut miyeloid lösemi ve alkilleyici ajanla -ilişkili miyelodisplastik sendromlar | Alkilleyici ajanla ilişkili AML ve miyelodisplastik sendromlar |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | C92.8 | NTBT | attributed | validated |
| ICD-11 | 2A60.20 | NTBT | index | validated |
| MONDO | 0015164 | E | validated | |
| UMLS | C1332234 | E | validated | |
| GARD | 19835 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (1):
- ORPHA:86846Therapy related acute myeloid leukemia and myelodysplastic syndrome
rare hematological diseases; rare neoplastic diseases; rare transplant-related disorders
No children.
Genes
0 directOrphanet records no gene directly on this code.
Prevalence and incidence
0 recordsNo prevalence record in this release.
HPO phenotypes
Orphanet has no HPO annotation for this code in this release.
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/102379
- This record as JSON: /data/d/102379.json