{"orpha":99918,"name":"Streptococcal toxic-shock syndrome","type":"Etiological subtype","group":"Subtype of disorder","status":"active","flags":[],"synonyms":["Streptococcal TSS"],"definition":"Streptococcal toxic-shock syndrome (streptococcal TSS) is an acute disease mediated by the production of superantigenic toxins characterized by the sudden onset of fever and other febrile symptoms, pain, multisystem organ involvement and potentially leading to coma, shock and death due to a <i>Streptococcus pyogenes</i> infection.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-99918/","orphanet_url":"https://www.orpha.net/en/disease/detail/99918","names":{"fr":{"name":"Syndrome du choc toxique streptococcique","synonyms":["SCT streptococcique"],"definition":"Maladie aiguë médiée par la production de toxines superantigéniques, caractérisée par l'apparition soudaine de fièvre et d'autres symptômes fébriles, de douleurs, d'une défaillance d'organes, pouvant conduire au coma, au choc et au décès dû à une infection à <i>Streptococcus pyogenes</i>."},"de":{"name":"Toxisches Schock-Syndrom, Streptokokken-induziertes","synonyms":["Streptokokken-TSS"],"definition":"Das durch Streptokokken verursachte toxische Schocksyndrom (Streptokokken-TSS) ist eine akute Erkrankung, die durch die Produktion von Superantigen-Toxinen ausgelöst wird und durch einen plötzlichen Beginn mit Fieber, anderen fieberhaften Symptomen, Schmerzen und Multiorganbeteiligung gekennzeichnet ist. Eine Infektion mit <i>Streptococcus pyogenes</i> kann zum Koma, Schock und zum Tod führen."},"es":{"name":"Síndrome de shock tóxico estreptocócico","synonyms":["Síndrome de shock tóxico por estreptococos","TSS por estreptococos"],"definition":"Es una enfermedad aguda mediada por la producción de toxinas superantigénicas y caracterizada por la aparición repentina de fiebre y otros síntomas febriles, dolor, afectación orgánica multisistémica que conduce potencialmente a coma, shock y fallecimiento debido a una infección por <i>Streptococcus pyogenes</i>."},"it":{"name":"Sindrome dello shock tossico da streptococco","synonyms":["TSS da streptococco"],"definition":"La sindrome dello shock tossico streptococcico (TSS streptococcica) è una malattia acuta mediata dalla produzione di tossine superantigeniche, caratterizzata dalla comparsa improvvisa di febbre e sintomi correlati, dolore e interessamento multiorgano; può esitare nel coma, nello shock e nel decesso a causa dell'infezione da Streptococcus pyogenes."},"nl":{"name":"Streptokokkale toxische shock-syndroom","synonyms":["Streptokokkale TSS"],"definition":"Streptococcale toxischeshocksyndroom (streptococcale TSS) is een acute ziekte die gemedieerd wordt door de productie van superantigene toxines, die gekenmerkt wordt door de plotse aanvang van koorts en andere febriele symptomen, pijn en multisystemische orgaanbetrokkenheid, en die potentieel leidt tot coma, shock en overlijden als gevolg van een infectie met <i>Streptococcus pyogenes</i>."},"pt":{"name":"Síndrome de choque tóxico estreptocócico"},"pl":{"name":"Paciorkowcowy zespół wstrząsu toksycznego","synonyms":["Paciorkowcowy TSS"]},"cs":{"name":"Streptokokový syndrom toxického šoku","synonyms":["Streptokokový TSS"]},"uk":{"name":"Стрептококовий синдром токсичного шоку","synonyms":["Стрептококовий TSS"],"definition":"Streptococcal toxic-shock syndrome (streptococcal TSS) is an acute disease mediated by the production of superantigenic toxins characterized by the sudden onset of fever and other febrile symptoms, pain, multisystem organ involvement and potentially leading to coma, shock and death due to a <i>Streptococcus pyogenes</i> infection."},"zh":{"name":"链球菌中毒性休克综合征","synonyms":["链球菌性TSS"],"definition":"链球菌中毒性休克综合征 (streptococcal TSS) 是一种由超抗原性毒素产生引起的急性疾病，以突然发热等发热症状、疼痛、多系统器官受累为特征，可能因化脓性链球菌感染 而导致昏迷、休克和死亡。"},"tr":{"name":"Streptokoksik toksik şok sendromu","synonyms":["Streptococcal TSS"]}},"xrefs":[{"source":"ICD-10","code":"A48.3","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"ICD-11","code":"1C45.0","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"197163558"},{"source":"MONDO","code":"0020544","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0343532","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10044251","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":68416,"name":"Rare infectious disease"},"parents":[{"orpha":36234,"name":"Bacterial toxic-shock syndrome","classifications":[203]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["All ages"],"prevalence":[{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.1,"area":"France","status":"Validated","source":"21976764[PMID]_Dr Lina Gérard[EXPERT]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.2,"area":"United States","status":"Validated","source":"22534148[PMID]_Dr Lina Gérard[EXPERT]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.33,"area":"Sweden","status":"Validated","source":"17638193[PMID]_Dr Lina Gérard[EXPERT]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.23,"area":"Denmark","status":"Validated","source":"15815000[PMID]"}],"phenotypes":null}