{"orpha":99824,"name":"Lassa fever","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":["LF","Lassa hemorrhagic fever"],"definition":"Lassa fever (LF) is a potentially severe viral hemorrhagic disease caused by Lassa virus and characterized by initial fever and malaise followed by gastrointestinal symptoms and, in severe cases, bleeding, shock and multi-organ system failure.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-99824/","orphanet_url":"https://www.orpha.net/en/disease/detail/99824","names":{"fr":{"name":"Fièvre de Lassa","synonyms":["Fièvre hémorragique de Lassa"],"definition":"La fièvre de Lassa est une maladie hémorragique virale potentiellement sévère causée par le virus Lassa. Elle est caractérisée initialement par une fièvre et un malaise, suivis par des symptômes gastro-intestinaux et dans les cas sévères, par une hémorragie, un choc et une défaillance multiviscérale."},"de":{"name":"Lassa-Fieber","synonyms":["LF","Lassa hämorrhagisches Fieber"],"definition":"Das Lassa-Fieber (LF) ist eine vom Lassa-Virus verursachte, potenziell schwer verlaufende hämorrhagische Erkrankung. Anfängliche Symptome sind Fieber und Unwohlsein. Es folgen gastrointestinale Symptome und, in schweren Fällen, Blutungen, Schock und systemisches Multiorganversagen."},"es":{"name":"Fiebre de Lassa","synonyms":["Fiebre hemorrágica de Lassa","LF"],"definition":"La fiebre de Lassa (LF) es una enfermedad hemorrágica vírica potencialmente grave causada por el virus de Lassa y caracterizada por fiebre inicial y malestar, seguidos de síntomas gastrointestinales y, en los casos graves, de sangrado, shock y fallo multiorgánico."},"it":{"name":"Febbre di Lassa","synonyms":["Febbre emorragica di Lassa","LF"],"definition":"La febbre di Lassa (LF) è una malattia emorragica virale potenzialmente grave, causata dal virus Lassa; è caratterizzata inizialmente da febbre e malessere, seguiti da sintomi gastrointestinali e, nei casi gravi, da shock e insufficienza sistemica multi-organo."},"nl":{"name":"Lassa-koorts","synonyms":["LF","Lassa hermorragische koorts"],"definition":"Lassakoorts (LF) is een potentieel ernstige virale hemorragische ziekte die veroorzaakt wordt door Lassavirus en die gekenmerkt wordt door initiële koorts en malaise, gevolgd door gastro-intestinale symptomen en, in ernstige gevallen, bloeding, shock en multi-orgaanfalen."},"pt":{"name":"Febre de Lassa"},"pl":{"name":"Gorączka Lassa","synonyms":["Gorączka krwotoczna Lassa","LF"]},"cs":{"name":"Horečka Lassa","synonyms":["LF","Lassa hemoragická horečka"]},"uk":{"name":"Лихоманка Ласса","synonyms":["Геморагічна лихоманка Ласса","LF"],"definition":"Lassa fever (LF) is a potentially severe viral hemorrhagic disease caused by Lassa virus and characterized by initial fever and malaise followed by gastrointestinal symptoms and, in severe cases, bleeding, shock and multi-organ system failure."},"zh":{"name":"拉沙热","synonyms":["拉沙出血热"],"definition":"拉萨热（LF）是由拉萨病毒引起的一种潜在的严重病毒性出血性疾病，其特征是最初发热和不适，随后出现胃肠道症状，严重时会出现出血、休克和多器官系统衰竭。"},"tr":{"name":"Lassa ateşi","synonyms":["LF","Lassa hemorajik ateşi"]}},"xrefs":[{"source":"ICD-10","code":"A96.2","qualifier":"E","icd_relation":"specific","validated":true},{"source":"ICD-11","code":"1D61.2","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"515020316"},{"source":"MONDO","code":"0005820","qualifier":"E","icd_relation":null,"validated":true},{"source":"MeSH","code":"D007835","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0023092","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10023927","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":68416,"name":"Rare infectious disease"},"parents":[{"orpha":341,"name":"Viral hemorrhagic fever","classifications":[203]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":[],"onset":["All ages"],"prevalence":[{"type":"Point prevalence","qualification":"Class only","class":"Unknown","value":0.0,"area":"Worldwide","status":"Not yet validated","source":"ORPHANET"},{"type":"Point prevalence","qualification":"Class only","class":"<1 / 1 000 000","value":0.0,"area":"Europe","status":"Validated","source":"European Medicines Agency 2018[OTHER]"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2021-08-30","source":"28701331[PMID]_32125412[PMID]_31518896[PMID]","terms":[{"hpo":"HP:0025406","label":"Asthenia","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0001945","label":"Fever","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0003496","label":"Increased circulating IgM level","frequency":"Very frequent (99-80%)","criteria":"Diagnostic criterion"},{"hpo":"HP:0400008","label":"Menometrorrhagia","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0005268","label":"Spontaneous abortion","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0020071","label":"Viremia","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0002027","label":"Abdominal pain","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0100749","label":"Chest pain","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0012735","label":"Cough","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002015","label":"Dysphagia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002315","label":"Headache","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001324","label":"Muscle weakness","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002017","label":"Nausea and vomiting","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0025439","label":"Pharyngitis","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001892","label":"Abnormal bleeding","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002829","label":"Arthralgia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0003418","label":"Back pain","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000509","label":"Conjunctivitis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002014","label":"Diarrhea","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002094","label":"Dyspnea","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000282","label":"Facial edema","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000365","label":"Hearing impairment","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000952","label":"Jaundice","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0100520","label":"Oliguria","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001622","label":"Premature birth","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001250","label":"Seizure","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0100806","label":"Sepsis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0031273","label":"Shock","frequency":"Occasional (29-5%)","criteria":null}]}}