{"orpha":99139,"name":"OBSOLETE: Unstable hemoglobin disease","type":"Disease","group":"Disorder","status":"inactive","flags":["Obsolete entity"],"synonyms":[],"definition":null,"note":"This entity has been obsoleted from the Orphanet nomenclature of rare diseases.<br/><br/>Instead, consider using Unstable beta globin chain variant disease","url":"https://raremap.alftech.space/d/ORPHA-99139/","orphanet_url":"https://www.orpha.net/en/disease/detail/99139","names":{"fr":{"name":"OBSOLETE : Maladie de l'hémoglobine instable"},"de":{"name":"OBSOLET: Hämolytische Anämie durch instabiles Hämoglobin"},"es":{"name":"OBSOLETO: Enfermedad de la hemoglobina inestable"},"it":{"name":"OBSOLETO: Malattia dell'emoglobina instabile"},"nl":{"name":"OBSOLEET: Ziekte door onstabiel hemoglobine"},"pt":{"name":"OBSOLETO: Doença de hemoglobina instável"},"pl":{"name":"NIEAKTUALNE: Choroba niestabilnej hemoglobiny"},"cs":{"name":"NEAKTUÁLNÍ: Nemoc nestabilního hemoglobinu"},"uk":{"name":"Захворювання з нестабільним гемоглобіном","definition":"A rare hemoglobinopathy characterized by variable degrees of hemolytic anemia, depending on the nature of the hemoglobin variant. In symptomatic patients, clinical manifestations are jaundice, splenomegaly, and, in patients with severe anemia, pallor. Additional features include reticulocytosis, presence of Heinz bodies, and pigmenturia."},"zh":{"name":"不稳定性血红蛋白病","definition":"该病是一种罕见的血红蛋白病，基于不同的血红蛋白改变有不同程度的溶血性贫血。患者临床表现为黄疸、脾肿大，严重贫血患者临床表现为苍白，其他特征包括网织红细胞增多、亨氏小体和色素尿。"},"tr":{"name":"Kararsız hemoglobin hastalığı"}},"xrefs":[],"associations":[{"type":"Referred to","orpha":231226,"name":"Unstable beta globin chain variant disease"}],"incoming_associations":[],"preferential_parent":null,"parents":[],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":[],"onset":[],"prevalence":[],"phenotypes":null}