{"orpha":98979,"name":"Chandler syndrome","type":"Clinical subtype","group":"Subtype of disorder","status":"active","flags":[],"synonyms":[],"definition":"A clinical variant of iridocorneal endothelial (ICE) syndrome, characterized by very few iris abnormalities but more severe corneal edema and less severe secondary glaucoma than seen in the other two ICE syndrome variants: Cogan-Reese syndrome and essential iris atrophy.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-98979/","orphanet_url":"https://www.orpha.net/en/disease/detail/98979","names":{"fr":{"name":"Syndrome de Chandler","definition":"Le syndrome de Chandler, la plus fréquente forme de syndrome irido-cornéo-endothélial (ICE), est caractérisé par très peu d'anomalies iriennes mais un oedème de la cornée plus sévère et un glaucome secondaire moins important que dans les deux autres variantes du syndrome ICE : le syndrome de Cogan-Resse et l'atrophie essentielle de l'iris."},"de":{"name":"Chandler-Syndrom","definition":"Das Chandler-Syndrom ist die häufigste klinische Variante des Irido-kornealen (ICE) Syndroms (s. dort). Kennzeichen sind die geringe Zahl von Irisanomalien, bei, im Vergleich zu den beiden anderen Varianten des ICE-Syndroms (Cogan-Reese-Syndrom und Essentielle Irisatrophie (s.diese Termini)), stärkerem Hornhautödem und weniger schwer ausgeprägtem sekundärem Glaukom."},"es":{"name":"Síndrome de Chandler","definition":"Es una variante clínica del síndrome endotelial iridocorneal (ICE), se caracteriza por presentar muy pocas anomalías en el iris pero sí edemas corneales más graves y un glaucoma secundario menos grave que los vistos en las otras dos variantes del síndrome ICE: el síndrome de Cogan-Reese y la atrofia esencial del iris."},"it":{"name":"Sindrome di Chandler","definition":"La sindrome di Chandler, la variante clinica più frequente della sindrome endoteliale iridocorneale (ICE), è caratterizzata da minime anomalie dell'iride, edema corneale grave e glaucoma secondario, meno grave rispetto a quelli descritti nella altre due varianti della sindrome ICE: la sindrome Cogan-Reese e l'atrofia essenziale dell'iride (si vedano questi termini)."},"nl":{"name":"Syndroom van Chandler","definition":"Een klinische variant van iridocorneaal endotheliaal (ICE) syndroom, gekarakteriseerd door zeer weinig afwijkingen van iris, maar met ernstiger corneaoedeem en minder ernstiger secundair glaucoom in vergelijking met de andere twee varianten van ICE-syndroom: syndroom van Cogan-Reese en essentiële irisatrofie."},"pt":{"name":"Síndrome Chandler"},"pl":{"name":"Zespół Chandlera"},"cs":{"name":"Chandlerův syndrom"},"uk":{"name":"Синдром Чандлера","definition":"A clinical variant of iridocorneal endothelial (ICE) syndrome, characterized by very few iris abnormalities but more severe corneal edema and less severe secondary glaucoma than seen in the other two ICE syndrome variants: Cogan-Reese syndrome and essential iris atrophy."},"zh":{"name":"Chandler综合征","definition":"该病是虹膜角膜内皮综合征(ICE)的一种临床亚型，其特征是虹膜极少数出现异常，相比其他两种ICE综合征（Cogan-Reese综合征和原发性虹膜萎缩），该病有更严重的角膜水肿和较轻的继发性青光眼。"},"tr":{"name":"Chandler sendromu"}},"xrefs":[{"source":"ICD-10","code":"H21.2","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"ICD-11","code":"LA11.Y","qualifier":"NTBT","icd_relation":"index","validated":true,"icd11_uri":"806443940"},{"source":"MONDO","code":"0020369","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0544008","qualifier":"E","icd_relation":null,"validated":true},{"source":"GARD","code":"6033","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10057487","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":97966,"name":"Rare ophthalmic disorder"},"parents":[{"orpha":64734,"name":"Iridocorneal endothelial syndrome","classifications":[147,156,189]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":[],"onset":[],"prevalence":[],"phenotypes":null}