{"orpha":98827,"name":"Unclassified myelodysplastic syndrome","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":[],"definition":"Unclassified myelodysplastic syndrome (MDS-U) is a subtype of myelodysplastic syndrome (MDS) with atypical features of uncertain clinical significance.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-98827/","orphanet_url":"https://www.orpha.net/en/disease/detail/98827","names":{"fr":{"name":"Syndrome myélodysplasique non-classifié","definition":"Sous-type de syndrome myélodysplasique (SMD) présentant des signes atypiques de signification clinique incertaine."},"de":{"name":"Myelodysplastisches Syndrom, nicht-klassifizierbares"},"es":{"name":"Síndrome mielodisplásico no clasificado","definition":"Es un subtipo de síndrome mielodisplásico (SMD) con alteraciones atípicas y de significación clínica incierta."},"it":{"name":"Sindrome mielodisplastica non classificata","definition":"La sindrome mielodisplastica non classificata (MDS-U) è un sottotipo della sindrome mielodisplastica (MDS; si veda questo termine). Presenta segni clinici atipici, di significato clinico incerto."},"nl":{"name":"Niet-geclassificeerd myelodysplastisch syndroom","definition":"Niet-geclassificeerd myelodysplastisch syndroom (MDS-U) is een subtype van myelodysplastisch syndroom (MDS; zie deze term) met atypische kenmerken met een onzekere klinische significantie."},"pt":{"name":"Síndrome mielodisplásico, não classificado"},"pl":{"name":"Niesklasyfikowany zespół mielodysplastyczny"},"cs":{"name":"Neklasifikovaný myelodysplastický syndrom"},"uk":{"name":"Некласифікований мієлодиспластичний синдром","definition":"Unclassified myelodysplastic syndrome (MDS-U) is a subtype of myelodysplastic syndrome (MDS; see this term) with atypical features of uncertain clinical significance."},"zh":{"name":"未分类骨髓增生异常综合征","definition":"未分类骨髓增生异常综合征(MDS-U)是骨髓增生异常综合征(MDS，见该词条)的一个亚型，特征不典型，临床意义也尚不明确。"},"tr":{"name":"Sınıflandırılmamış miyelodisplastik sendrom"}},"xrefs":[{"source":"ICD-10","code":"D46.7","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"ICD-11","code":"2A37","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"1684468291"},{"source":"MONDO","code":"0020315","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C5681636","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":250908,"name":"Rare neoplastic disease"},"parents":[{"orpha":86836,"name":"Refractory cytopenia with multilineage dysplasia","classifications":[194,202,233]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["All ages"],"prevalence":[{"type":"Annual incidence","qualification":"Class only","class":"Unknown","value":0.0,"area":"Worldwide","status":"Validated","source":"WHO Tumour classification[OTHER]"},{"type":"Point prevalence","qualification":"Class only","class":"Unknown","value":0.0,"area":"Worldwide","status":"Validated","source":"WHO Tumour classification[OTHER]"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2019-06-11","source":"26799610[PMID]_28297619[PMID]_27039723[PMID]_17709138[PMID]_30091023[PMID]_30555034[PMID]","terms":[{"hpo":"HP:0002863","label":"Myelodysplasia","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0045040","label":"Abnormal lactate dehydrogenase activity","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001871","label":"Abnormality of blood and blood-forming tissues","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0012378","label":"Fatigue","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0012148","label":"Multiple lineage myelodysplasia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002960","label":"Autoimmunity","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0005528","label":"Bone marrow hypocellularity","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001974","label":"Increased total leukocyte count","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0030166","label":"Night sweats","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0004808","label":"Acute myeloid leukemia","frequency":"Very rare (<4-1%)","criteria":null}]}}