{"orpha":97335,"name":"Osgood-Schlatter disease","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":["Aseptic necrosis of the tibial tubercle","Osteochondrosis of the tibial tubercle"],"definition":"Osgood-Schlatter disease is a traction apophysitis of the anterior tibial tubercle described in active adolescents and characterized by gradual onset of pain and swelling of the anterior knee causing limping that usually disappears at the end of growth.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-97335/","orphanet_url":"https://www.orpha.net/en/disease/detail/97335","names":{"fr":{"name":"Maladie d'Osgood-Schlatter","synonyms":["Nécrose aseptique du tubercule tibial","Ostéochondrite du tubercule tibial"],"definition":"Apophysite de traction du tubercule tibial antérieur décrite chez les adolescents actifs et caractérisée par l'apparition progressive d'une douleur et d'un gonflement à l'avant du genou provoquant une boiterie et disparaissant généralement à la fin de la période de croissance."},"de":{"name":"Osgood-Schlatter-Krankheit","synonyms":["Aseptische Nekrose des Tuberositas tibiae","Osteochondritis des Tuberositas tibiae","Osteochondrosis des Tuberositas tibiae"],"definition":"Die Osgood-Schlatter-Krankheit ist eine durch Zug verursachte Apophysitis des vorderen Tibia-Tuberkels. Sie tritt bei körperlich aktiven Adoleszenten auf und ist gekennzeichnet durch allmählich einsetzende Schmerzen und Schwellungen an der Vorderseite der Kniee, weshalb die Patienten humpeln. In der Regel normalisiert sich der Gang zum Ende der Wachstumsperiode."},"es":{"name":"Enfermedad de Osgood-Schlatter","synonyms":["Osteocondritis de la tuberosidad de la tibia","Osteocondritis del tubérculo tibial","Osteocondrosis de la tuberosidad de la tibia","Osteocondrosis del tubérculo tibial","Necrosis aséptica de la tuberosidad de la tibia","Necrosis aséptica del tubérculo tibial"],"definition":"La enfermedad de Osgood-Schlatter es una apofisitis por tracción de la tuberosidad anterior de la tibia descrita en adolescentes activos y que se caracteriza por la aparición gradual de dolor e hinchazón en la rodilla anterior causando cojera y que normalmente desaparece al final del crecimiento."},"it":{"name":"Malattia di Osgood-Schlatter","synonyms":["Necrosi asettica del tubercolo tibiale","Osteocondrite del tubercolo tibiale","Osteocondrosi del tubercolo tibiale"],"definition":"La malattia di Osgood-Schlatter è un'apofisite da trazione del tubercolo anteriore della tibia, descritta negli adolescenti attivi, caratterizzata da un esordio graduale del dolore e del gonfiore a livello della parte anteriore del ginocchio, a cui consegue una deambulazione zoppicante, che di solito scompare alla fine della crescita."},"nl":{"name":"Ziekte van Osgood-Schlatter","synonyms":["Aseptische necrose van de tibia-tuberkel","Osteochondrose van de tibia-tuberkel"],"definition":"Een apofysitis door tractie van anterieure tuberositas tibiae, beschreven bij actieve adolescenten, en gekenmerkt door geleidelijk optreden van pijn en zwelling van anterieure knie, wat leidt tot mank lopen dat meestal verdwijnt tegen het einde van de groei."},"pt":{"name":"Doença de Osgood-Schlatter"},"pl":{"name":"Choroba Osgooda i Schlattera","synonyms":["Jałowa martwica guzowatości kości piszczelowej","Osteochondroza guzowatości kości piszczelowej"]},"cs":{"name":"Osgoodova-Schlatterova nemoc","synonyms":["Aseptická nekróza tuberositas tibiae","Osteochondróza tuberositas tibiae","Osgood-Schlatterova nemoc"]},"uk":{"name":"Хвороба Осгуда-Шлаттера","synonyms":["Асептичний некроз горбка великогомілкової кістки","Остеохондроз горбка великогомілкової кістки"],"definition":"Osgood-Schlatter disease is a traction apophysitis of the anterior tibial tubercle described in active adolescents and characterized by gradual onset of pain and swelling of the anterior knee causing limping that usually disappears at the end of growth."},"zh":{"name":"奥-施病","synonyms":["胫骨结节无菌性坏死"],"definition":"Osgood-Schlater病是一种胫骨前结节的牵引性骨骺炎，见于活跃的青少年，其特征是前膝逐渐开始疼痛和肿胀，导致跛行，通常在生长末期消失。"},"tr":{"name":"Osgood-Schlatter hastalığı","synonyms":["Tibial tüberkülün osteokondrozu","Tibial tüberkülün aseptik nekrozu"]}},"xrefs":[{"source":"ICD-10","code":"M92.5","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"ICD-11","code":"FB82.1","qualifier":"NTBT","icd_relation":"index","validated":true,"icd11_uri":"1417227232"},{"source":"MONDO","code":"0004241","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0029376","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10031130","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":93419,"name":"Rare bone disease"},"parents":[{"orpha":399319,"name":"Osteochondrosis","classifications":[196,199]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["Adolescent","Childhood"],"prevalence":[{"type":"Point prevalence","qualification":"Class only","class":"Unknown","value":0.0,"area":"Worldwide","status":"Not yet validated","source":"ORPHANET"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2019-06-14","source":"27752406[PMID]_30538899[PMID]_31019825[PMID]_28723024[PMID]_28593576[PMID]","terms":[{"hpo":"HP:0030839","label":"Knee pain","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0003045","label":"Abnormal patella morphology","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0009046","label":"Difficulty running","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001288","label":"Gait disturbance","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0006456","label":"Irregular proximal tibial epiphyses","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0003066","label":"Limited knee extension","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0030866","label":"Large knee","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002362","label":"Shuffling gait","frequency":"Occasional (29-5%)","criteria":null}]}}