{"orpha":97330,"name":"Thoracic outlet syndrome","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":["TOS","Thoracic outlet compression syndrome"],"definition":"Thoracic outlet syndrome (TOS) is a group of disorders characterized by paresthesias, pain and weakness of the upper extremities due to compression, tension or inflammation of the neurovascular bundle as it passes through the thoracic outlet. There are 3 forms of TOS with different clinical pictures and etiologies: neurogenic TOS (NTOS) that can be divided into true or disputed forms, arterial TOS (ATOS) and venous TOS (VTOS).","note":null,"url":"https://raremap.alftech.space/d/ORPHA-97330/","orphanet_url":"https://www.orpha.net/en/disease/detail/97330","names":{"fr":{"name":"Syndrome du défilé thoracique","synonyms":["SDT","Syndrome de la traversée cervico-thoraco-brachiale","Syndrome du défilé cervico-thoraco-brachial","TOS"],"definition":"Groupe de maladies caractérisées par des paresthésies, des douleurs et des faiblesses des membres supérieures dues à une compression, une tension ou une inflammation des paquets vasculo-nerveux qui passent par le défilé thoracique. Il existe trois formes de syndrome du défilé thoracique (SDT) avec des tableaux cliniques et des étiologies différents : le SDT neurogène (SDTN) qui peut être divisé en formes vraies ou objectivées, le SDT artériel (SDTA) et le SDT veineux (SDTV)."},"de":{"name":"Thoracic-outlet-Syndrom","definition":"Das Thoracic-outlet-Syndrome (TOS) (auch: Engpass-Syndrom der oberen Thoraxapertur) ist eine Gruppe von Störungen, die durch Parästhesien, Schmerzen und Schwäche der oberen Extremitäten aufgrund von Kompression, Spannung oder Entzündung des neurovaskulären Gefäß-Nervenbündels bei dessen Durchgang durch die obere Thoraxapertur gekennzeichnet ist. Es gibt 3 Formen des TOS mit jeweils unterschiedlichen klinischen Bildern und Ätiologien: Das neurogene TOS (NTOS), das in echte und umstrittene Formen unterteilt werden kann, das arterielle TOS (ATOS) und das venöse TOS (VTOS) (siehe jeweils dort)."},"es":{"name":"Síndrome de la salida torácica","synonyms":["SST","TOS"],"definition":"El síndrome de la salida torácica (TOS) es un grupo de trastornos que se caracterizan por parestesias, dolor y debilidad en las extremidades superiores debido a la compresión, tensión o inflamación de los haces neurovasculares cuando pasan a través de la salida torácica. Hay 3 formas de TOS con diferentes cuadros clínicos y etiologías: TOS neurogénico (NTOS) que puede dividirse en las formas verdadera y dudosa, TOS arterial (ATOS) y TOS venoso (VTOS) (consulte estos términos)."},"it":{"name":"Sindrome dello stretto toracico","synonyms":["TOS"],"definition":"La sindrome dello stretto toracico (TOS) definisce un gruppo di malattie caratterizzate da parestesie, dolore e debolezza a livello degli arti superiori, da compressione, tensione o infiammazione del fascio neurovascolare che attraversa lo stretto toracico. Sono noti tre tipi di TOS, associati a diversi quadri clinici ed eziologie: la TOS neurogena (NTOS), che comprende le forme vere e quelle discusse, la TOS arteriosa (ATOS) e la TOS venosa (VTOS) (si vedano questi termini)."},"nl":{"name":"Thoracic outlet-syndroom","synonyms":["Thoracic outlet-compressiesyndroom","TOS"],"definition":"Thoracic outlet-syndroom (TOS) is een verzamelnaam voor een groep aandoeningen die gekarakteriseerd worden door paresthesieën, pijn en zwakheid aan de bovenste ledematen ten gevolge van compressie, en spanning of ontsteking van de neurovasculaire bundel in het gebied van de bovenste thoraxapertuur. Er zijn 3 vormen van TOS met elk een ander klinisch beeld en een andere etiologie: neurogeen TOS (NTOS) dat kan onderverdeeld worden in echte en omstreden vormen, arterieel TOS (ATOS) en veneus TOS (VTOS) (zie deze termen)."},"pt":{"name":"Síndrome do canal torácico"},"pl":{"name":"Zespół górnego otworu klatki piersiowej","synonyms":["TOS","Zespół uciskowy górnego otworu klatki"]},"cs":{"name":"Syndrom horní hrudní apertury","synonyms":["TOS","Kompresivní syndrom horní hrudní apertury"]},"uk":{"name":"Синдром грудного виходу","synonyms":["Синдром здавлення грудного отвору легеневої артерії","TOS"],"definition":"Thoracic outlet syndrome (TOS) is a group of disorders characterized by paresthesias, pain and weakness of the upper extremities due to compression, tension or inflammation of the neurovascular bundle as it passes through the thoracic outlet. There are 3 forms of TOS with different clinical pictures and etiologies: neurogenic TOS (NTOS) that can be divided into true or disputed forms, arterial TOS (ATOS) and venous TOS (VTOS) (see these terms)."},"zh":{"name":"胸廓出口综合征","synonyms":["胸廓出口压迫综合征"],"definition":"胸廓出口综合征(TOS)是一组以上肢感觉异常、疼痛和无力为特征的疾病，主要原因是神经血管束在通过胸廓出口时受到压迫，引起紧张或炎症。有3种类型的TOS，分别具有不同的临床表现和病因：神经源性TOS(NTOS)(可分为真性TOS或尚有争议TOS)，动脉型TOS(ATOS)和静脉型TOS(VTOS)(见该类词条)。"},"tr":{"name":"Torasik çıkış sendromu","synonyms":["TOS","Torasik çıkış kompresyon sendromu"]}},"xrefs":[{"source":"ICD-10","code":"G54.0","qualifier":"NTBT","icd_relation":"inclusion","validated":true},{"source":"ICD-11","code":"8B91.Y","qualifier":"NTBT","icd_relation":"index","validated":true,"icd11_uri":"909280105"},{"source":"MONDO","code":"0005979","qualifier":"E","icd_relation":null,"validated":true},{"source":"MeSH","code":"D013901","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0039984","qualifier":"E","icd_relation":null,"validated":true},{"source":"GARD","code":"7759","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10048627","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[{"type":"Referred to","orpha":100072,"name":"OBSOLETE: True vascular thoracic outlet syndrome","status":"inactive"}],"preferential_parent":{"orpha":97962,"name":"Rare surgical thoracic disease"},"parents":[{"orpha":97962,"name":"Rare surgical thoracic disease","classifications":[186]}],"children":[{"orpha":357107,"name":"Arterial thoracic outlet syndrome","type":"Clinical subtype"},{"orpha":100073,"name":"Neurogenic thoracic outlet syndrome","type":"Clinical subtype"},{"orpha":357131,"name":"Venous thoracic outlet syndrome","type":"Clinical subtype"}],"genes":[],"genes_via_subtypes":[],"inheritance":[],"onset":["Adult","Elderly"],"prevalence":[{"type":"Point prevalence","qualification":"Class only","class":"Unknown","value":0.0,"area":"Worldwide","status":"Not yet validated","source":"ORPHANET"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2016-06-01","source":"26251937[PMID]","terms":[{"hpo":"HP:0003401","label":"Paresthesia","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0000772","label":"Abnormal rib morphology","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002829","label":"Arthralgia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000969","label":"Edema","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001324","label":"Muscle weakness","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0003326","label":"Myalgia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0003457","label":"EMG abnormality","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0003394","label":"Muscle spasm","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000763","label":"Sensory neuropathy","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002619","label":"Varicose veins","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0004936","label":"Venous thrombosis","frequency":"Occasional (29-5%)","criteria":null}]}}