{"orpha":97292,"name":"Cardiogenic shock","type":"Particular clinical situation in a disease or syndrome","group":"Disorder","status":"active","flags":[],"synonyms":[],"definition":"A rare, cardiac condition characterized by severely decreased cardiac output, hypoperfusion and end-organ dysfunction, in the presence of adequate intravascular volume. The clinical presentation is variable and may range from subtle hemodynamic alterations to overt cardiovascular collapse. Commonly reported features include dyspnea, crackles, elevated jugular venous pressure, altered mental state, abnormal pulse pressure, oliguria, cold extremities, and increased serum lactate levels.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-97292/","orphanet_url":"https://www.orpha.net/en/disease/detail/97292","names":{"fr":{"name":"Choc cardiogénique","definition":"Maladie cardiaque rare, caractérisée par une diminution importante du débit cardiaque, une hypoperfusion et un dysfonctionnement des organes terminaux, en présence d'un volume intravasculaire adéquat. La présentation clinique est variable et peut aller d'altérations hémodynamiques subtiles à un collapsus cardiovasculaire manifeste. Les caractéristiques les plus courantes sont la dyspnée, les crépitations, l'élévation de la pression veineuse jugulaire, l'altération de l'état mental, l'anomalie du pouls, l'oligurie, des extrémités froides et l'augmentation des taux de lactate sérique."},"de":{"name":"Kardiogener Schock","definition":"Eine seltene kardiale Erkrankung, die durch ein stark vermindertes Herzzeitvolumen, Hypoperfusion und Dysfunktion der Endorgane gekennzeichnet ist, obwohl ein ausreichendes intravaskuläres Volumen vorhanden ist. Das klinische Erscheinungsbild ist unterschiedlich und kann von subtilen hämodynamischen Veränderungen bis hin zum offenen kardiovaskulären Kollaps reichen. Zu den häufig berichteten Merkmalen gehören Dyspnoe, Knistern, erhöhter Jugularvenendruck, veränderter Geisteszustand, abnormaler Pulsdruck, Oligurie, kalte Extremitäten und erhöhte Serumlaktatwerte."},"es":{"name":"Shock cardiogénico","synonyms":["Choque cardiogénico"],"definition":"Es una afección cardíaca poco frecuente caracterizada por una disminución severa del gasto cardíaco, hipoperfusión y disfunción de los órganos diana, en presencia de un volumen intravascular adecuado. La presentación clínica es variada y puede oscilar desde leves alteraciones hemodinámicas hasta un colapso cardiovascular manifiesto. Las características descritas con mayor frecuencia incluyen disnea, crepitantes, presión venosa yugular elevada, alteración del estado mental, presión del pulso anómala, oliguria, extremidades frías e incremento de los niveles de lactato sérico."},"it":{"name":"Shock cardiogeno","definition":"Si tratta di una cardiopatia rara, caratterizzata da una grave riduzione della gittata cardiaca, ipoperfusione e disfunzione dell'organo bersaglio, in presenza di un volume intravascolare adeguato. Il quadro clinico è variabile e comprende le alterazioni emodinamiche lievi, fino al collasso cardiovascolare conclamato. I sintomi più comuni sono la dispnea, i rantoli, l'elevata pressione venosa giugulare, lo stato mentale alterato, le anomalie del polso, l'oliguria, le estremità fredde e l'aumento dei livelli di lattato nel siero."},"nl":{"name":"Cardiogene shock","definition":"Een zeldzame hartaandoening, gekarakteriseerd door ernstig verminderd hartminuutvolume, hypoperfusie en disfunctie van eindorgaan, in aanwezigheid van adequaat intravasculair volume. De klinische presentatie is variabel en kan gaan van subtiele hemodynamische veranderingen tot duidelijk waarneembare cardiovasculaire collaps. Gangbaar gerapporteerde kenmerken zijn onder meer dyspneu, ademgeruis, verhoogde druk in vena jugularis, gewijzigde mentale toestand, abnormale polsdruk, oligurie, koud aanvoelende ledematen, en verhoogde lactaatgehaltes in serum."},"pt":{"name":"Tratamento de choque cardiogénico"},"pl":{"name":"Wstrząs kardiogenny"},"cs":{"name":"Kardiogenní šok"},"uk":{"name":"Кардіогенний шок","definition":"A rare, cardiac condition characterized by severely decreased cardiac output, hypoperfusion and end-organ dysfunction, in the presence of adequate intravascular volume. The clinical presentation is variable and may range from subtle hemodynamic alterations to overt cardiovascular collapse. Commonly reported features include dyspnea, crackles, elevated jugular venous pressure, altered mental state, abnormal pulse pressure, oliguria, cold extremities, and increased serum lactate levels."},"zh":{"name":"心源性休克","definition":"该病是一种罕见的心脏病，其特征是心输出量严重下降、灌注不足和末梢器官功能障碍，但血管内容量充足。临床表现多变，可能表现从细微的血流动力学改变到明显的心血管衰竭。常见表现包括呼吸困难、裂纹、颈静脉压升高、精神状态改变、脉压异常、少尿、四肢冰冷和血清乳酸水平升高。"},"tr":{"name":"Kardiyojenik şok"}},"xrefs":[{"source":"ICD-10","code":"R57.0","qualifier":"E","icd_relation":"specific","validated":true},{"source":"ICD-11","code":"MG40.0","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"1974956233"},{"source":"MONDO","code":"0800175","qualifier":"E","icd_relation":null,"validated":true},{"source":"MeSH","code":"D012770","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0036980","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10007625","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":97929,"name":"Rare cardiac disease"},"parents":[{"orpha":97929,"name":"Rare cardiac disease","classifications":[146]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["Adolescent","Adult","Childhood","Elderly"],"prevalence":[{"type":"Point prevalence","qualification":"Value and class","class":"1-5 / 10 000","value":40.0,"area":"Europe","status":"Validated","source":"European Medicines Agency 2008[OTHER]"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2023-08-10","source":"29412021[PMID]_28923988[PMID_29173681[PMID]_30947630[PMID]","terms":[{"hpo":"HP:0003115","label":"Abnormal EKG","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0005162","label":"Abnormal left ventricular function","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0002615","label":"Hypotension","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0009805","label":"Low-output congestive heart failure","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0011675","label":"Arrhythmia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001695","label":"Cardiac arrest","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001635","label":"Congestive heart failure","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0030830","label":"Crackles","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000961","label":"Cyanosis","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002094","label":"Dyspnea","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000969","label":"Edema","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0030848","label":"Elevated jugular venous pressure","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0012418","label":"Hypoxemia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0006670","label":"Impaired myocardial contractility","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0030876","label":"Increased pulmonary capillary wedge pressure","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0030851","label":"Low pulse pressure","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001658","label":"Myocardial infarction","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0100520","label":"Oliguria","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0012764","label":"Orthopnea","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0004372","label":"Reduced consciousness","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001289","label":"Confusion","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0003259","label":"Elevated circulating creatinine concentration","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002240","label":"Hepatomegaly","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002151","label":"Increased circulating lactate concentration","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001942","label":"Metabolic acidosis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001653","label":"Mitral regurgitation","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0012251","label":"ST segment elevation","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002321","label":"Vertigo","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001259","label":"Coma","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001708","label":"Right ventricular failure","frequency":"Very rare (<4-1%)","criteria":null}]}}