{"orpha":95619,"name":"Post-traumatic pituitary deficiency","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":[],"definition":"A rare, acquired, endocrine disorder characterized by deficiency of one or more of the pituitary hormones resulting as a consequence of traumatic or medically-induced injury of the pituitary gland. Clinical presentation is variable depending on the nature and acuity of the injury and the resulting order and amount of hormone deficiency.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-95619/","orphanet_url":"https://www.orpha.net/en/disease/detail/95619","names":{"fr":{"name":"Insuffisance hypophysaire d'origine post-traumatique","definition":"Maladie endocrinienne acquise rare caractérisée par une insuffisance d'une ou de plusieurs hormones hypophysaires à la suite d'une lésion hypophysaire iatrogène ou traumatique. La présentation clinique varie en fonction de la nature et de la sévérité de la lésion, ainsi que du nombre et de l'importance d'hormones affectées et du déficit hormonal qui en résulte."},"de":{"name":"Hypophysenfunktionsstörung, posttraumatische","definition":"Eine erworbene endokrine Störung, die durch einen Mangel an einem oder mehreren Hypophysenhormonen gekennzeichnet ist, der als Folge einer traumatischen oder medizinisch bedingten Verletzung der Hypophyse auftritt. Das klinische Erscheinungsbild ist je nach Art und Schwere der Verletzung und der daraus resultierenden Reihenfolge und Menge des Hormonmangels unterschiedlich."},"es":{"name":"Deficiencia hipofisaria postraumática","definition":"Es un trastorno endocrino, adquirido y poco frecuente, caracterizado por la deficiencia de una o más hormonas hipofisarias como consecuencia de una lesión traumática o médicamente inducida de la glándula pituitaria. La presentación clínica varía en función de la naturaleza y la agudeza de la lesión, así como del orden y la cantidad de deficiencia hormonal resultante."},"it":{"name":"Deficit ipofisario iatrogeno o traumatico","definition":"Il deficit ipofisario iatrogeno o traumatico è un'endocrinopatia rara acquisita, caratterizzata dal deficit di uno o più ormoni ipofisari, secondaria ad una lesione dell'ipofisi di natura traumatica o indotta medicalmente. Il quadro clinico è variabile e dipende dalla natura e dalla gravità della lesione, nonché dal grado del deficit ormonale che ne deriva."},"nl":{"name":"Posttraumatische hypofysedeficiëntie","definition":"Een zeldzame verworven endocriene aandoening, gekenmerkt door deficiëntie van één of meer hypofysehormonen als gevolg van traumatisch of medisch geïnduceerd letsel van hypofyse. Het klinisch beeld varieert afhankelijk van de aard en ernst van de verwonding, en de mate van resulterende hormoondeficiëntie."},"pt":{"name":"Deficiência pituitária pós-traumática"},"pl":{"name":"Jatrogenny lub pourazowy Niedobór hormonów przysadki","definition":"Rzadkie, nabyte zaburzenie endokrynologiczne charakteryzujące się niedoborem jednego lub więcej hormonów przysadki wskutek urazowego lub jatrogennego uszkodzenia przysadki. Obraz kliniczny różni się w zależności od charakteru i ciężkości urazu oraz wynikającego z niego jakościowego i ilościowego niedoboru hormonów."},"cs":{"name":"Iatrogenní nebo traumatický deficit hormonů hypofýzy"},"uk":{"name":"Посттравматичний дефіцит гормонів гіпофізу","definition":"A rare, acquired, endocrine disorder characterized by deficiency of one or more of the pituitary hormones resulting as a consequence of traumatic or medically-induced injury of the pituitary gland. Clinical presentation is variable depending on the nature and acuity of the injury and the resulting order and amount of hormone deficiency."},"zh":{"name":"创伤后垂体缺陷","definition":"医源性或创伤性垂体缺陷是一种罕见的获得性内分泌紊乱，其特征是由于垂体的外伤性或医学性损伤而导致一种或多种垂体激素缺乏。临床表现取决于损伤的性质和严重程度，以及由此导致的激素缺乏的顺序和量。"},"tr":{"name":"Travma sonrası hipofiz eksikliği"}},"xrefs":[{"source":"ICD-10","code":"E23.6","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"ICD-11","code":"5A61.0","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"MONDO","code":"0019845","qualifier":"E","icd_relation":null,"validated":true},{"source":"MONDO","code":"19845","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0342400","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[{"type":"Referred to","orpha":95621,"name":"OBSOLETE: Postsurgical hypopituitarism","status":"inactive"},{"type":"Referred to","orpha":95623,"name":"OBSOLETE: Posttraumatic hypopituitarism","status":"inactive"}],"preferential_parent":{"orpha":97978,"name":"Rare endocrine disease"},"parents":[{"orpha":95502,"name":"Acquired pituitary hormone deficiency","classifications":[193]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":[],"onset":["Adolescent","Adult","Childhood","Elderly"],"prevalence":[],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2017-04-10","source":"24635130[PMID]_26307884[PMID]_24243629[PMID]_23690314[PMID]_22090267[PMID]_17895459[PMID]_18234750[PMID]_17467517[PMID]_15472187[PMID]_16378796[PMID]_4301762[PMID]","terms":[{"hpo":"HP:0040086","label":"Abnormal prolactin level","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000141","label":"Amenorrhea","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002920","label":"Decreased circulating ACTH level","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000824","label":"Decreased response to growth hormone stimulation test","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0012378","label":"Fatigue","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001943","label":"Hypoglycemia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000044","label":"Hypogonadotropic hypogonadism","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002615","label":"Hypotension","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000789","label":"Infertility","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000938","label":"Osteopenia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0005625","label":"Osteoporosis of vertebrae","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0009888","label":"Abnormality of secondary sexual hair","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0010311","label":"Aplasia/Hypoplasia of the breasts","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0000863","label":"Central diabetes insipidus","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0008734","label":"Decreased testicular size","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0000823","label":"Delayed puberty","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0002750","label":"Delayed skeletal maturation","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001510","label":"Growth delay","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0000871","label":"Panhypopituitarism","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0008245","label":"Pituitary hypothyroidism","frequency":"Very rare (<4-1%)","criteria":null}]}}