{"orpha":95512,"name":"Adenohypophysitis","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":["Anterior pituitary hypophysitis"],"definition":"A rare, acquired pituitary hormone deficiency, a type of primary hypophysitis characterized by an inflammation of anterior pituitary. Clinical presentation is variable and includes headaches, visual disturbances, symptoms of adrenal insufficiency, hyperprolactinemia, hypothyroidism and hypogonadism. It most commonly affects young women during pregnancy or postpartum period.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-95512/","orphanet_url":"https://www.orpha.net/en/disease/detail/95512","names":{"fr":{"name":"Adénohypophysite","synonyms":["Hypophysite de l'hypophyse antérieure"],"definition":"Insuffisance hypophysaire acquise rare à type d'hypophysite primitive caractérisée par une inflammation de l'antéhypophyse. Variable, le tableau clinique comprend des maux de tête, des troubles visuels, des symptômes d'insuffisance surrénale, d'hyperprolactinémie, d'hypothyroïdie et d'hypogonadisme. La maladie touche le plus souvent les jeunes femmes pendant la grossesse ou la période du post-partum."},"de":{"name":"Adenohypophysitis, lymphozytische"},"es":{"name":"Adenohipofisitis","synonyms":["Hipofisitis pituitaria anterior"],"definition":"Es una deficiencia de hormona hipofisaria adquirida poco frecuente, un tipo de hipofisitis primaria caracterizada por inflamación de la hipófisis anterior. La presentación clínica es variable e incluye cefaleas, trastornos visuales, síntomas de insuficiencia suprarrenal, hiperprolactinemia, hipotiroidismo e hipogonadismo. Afecta, más frecuentemente, a mujeres jóvenes durante el embarazo o el postparto."},"it":{"name":"Adenoipofisite","synonyms":["Ipofisite dell'ipofisi anteriore"],"definition":"L'adenoipofisite è un difetto raro acquisito degli ormoni dell'ipofisi, un'ipofisite primitiva caratterizzata dall'infiammazione dell'ipofisi anteriore. Il quadro clinico è variabile e comprende la cefalea, i disturbi visivi, i sintomi caratteristici dell'insufficienza surrenalica, l'iperprolattinemia, l'ipotiroidismo e l'ipogonadismo. Colpisce per lo più le donne giovani durante la gravidanza o nel periodo postpartum."},"nl":{"name":"Adenohypofysitis","synonyms":["Anterieure pituïtaire hypofysitis"],"definition":"Een zeldzame, verworven hypofysaire hormoondeficiëntie en een type van primaire hypofysitis, gekarakteriseerd door inflammatie van de anterieure hypofyse. Het klinisch beeld is variabel en omvat hoofdpijn, visuele stoornissen, symptomen van bijnierschorsinsufficiëntie, hyperprolactinemie, hypothyreoïdie en hypogonadisme. Deze aandoening treft doorgaans jonge vrouwen tijdens de zwangerschap of postpartumperiode."},"pt":{"name":"Adeno-hipofisite linfocítica"},"pl":{"name":"Zapalenie gruczołowej części przysadki","synonyms":["Zapalenie przedniej części przysadki"],"definition":"*Zapalenie gruczołowej części przysadki jest rzadkim nabytym niedoborem hormonów przysadki; jest to typ pierwotnego zapalenia przysadki - charakteryzuje się zapaleniem przedniego płata przysadki. Obraz kliniczny jest zmienny i obejmuje bóle głowy, zaburzenia widzenia, objawy niewydolności kory nadnerczy, hiperprolaktynemię, niedoczynność tarczycy i hipogonadyzm. Najczęściej chorują młode kobiety w okresie ciąży lub połogu."},"cs":{"name":"Adenohypofyzitida","synonyms":["Zánět předního laloku hypofýzy"]},"uk":{"name":"Аденогіпофізит","synonyms":["Гіпофіз передньої частки гіпофіза"],"definition":"A rare, acquired pituitary hormone deficiency, a type of primary hypophysitis characterized by an inflammation of anterior pituitary. Clinical presentation is variable and includes headaches, visual disturbances, symptoms of adrenal insufficiency, hyperprolactinemia, hypothyroidism and hypogonadism. It most commonly affects young women during pregnancy or postpartum period."},"zh":{"name":"腺垂体炎","synonyms":["垂体前叶炎"],"definition":"一种罕见的获得性垂体激素缺乏症，是一种以垂体前叶炎症为特征的原发性垂体炎。临床表现多变，包括头痛、视力障碍、肾上腺功能不全、高催乳素血症、甲状腺功能减退和性腺功能减退。该病最常见于怀孕或产后的年轻女性。"},"tr":{"name":"Adenohipofizit","synonyms":["Anterior hipofiz hipofiziti"]}},"xrefs":[{"source":"ICD-10","code":"E23.6","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"ICD-11","code":"5A61.0","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"MONDO","code":"0019838","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C5190880","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":97978,"name":"Rare endocrine disease"},"parents":[{"orpha":95506,"name":"Primary hypophysitis","classifications":[193]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":[],"onset":["Adolescent","Adult"],"prevalence":[],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2017-06-30","source":"23885185[PMID]_27008424[PMID]_18987830[PMID]_17273922[PMID]_14606714[PMID]_27165294[PMID]","terms":[{"hpo":"HP:0000871","label":"Panhypopituitarism","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0012504","label":"Abnormal size of pituitary gland","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0012696","label":"Abnormal thalamic MRI signal intensity","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0011748","label":"Adrenocorticotropic hormone deficiency","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0011735","label":"Adrenocorticotropin deficient adrenal insufficiency","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000141","label":"Amenorrhea","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000622","label":"Blurred vision","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0008163","label":"Decreased circulating cortisol level","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0030018","label":"Decreased female libido","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0040306","label":"Decreased male libido","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0008214","label":"Decreased serum estradiol","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0040171","label":"Decreased serum testosterone concentration","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0008213","label":"Gonadotropin deficiency","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002315","label":"Headache","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0003158","label":"Hyposthenuria","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000802","label":"Impotence","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000870","label":"Increased circulating prolactin concentration","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002018","label":"Nausea","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001895","label":"Normochromic anemia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001278","label":"Orthostatic hypotension","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000980","label":"Pallor","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0008245","label":"Pituitary hypothyroidism","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0007987","label":"Progressive visual field defects","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0008240","label":"Secondary growth hormone deficiency","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0003493","label":"Antinuclear antibody positivity","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0007041","label":"Chronic lymphocytic meningitis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000651","label":"Diplopia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000872","label":"Hashimoto thyroiditis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002902","label":"Hyponatremia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0004396","label":"Poor appetite","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0008202","label":"Reduced circulating prolactin concentration","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000407","label":"Sensorineural hearing impairment","frequency":"Occasional (29-5%)","criteria":null}]}}