{"orpha":95465,"name":"Cleft mitral valve","type":"Morphological anomaly","group":"Disorder","status":"active","flags":[],"synonyms":[],"definition":"A rare, congenital, non-syndromic heart malformation characterized by a slit-like hole or defect in one of the mitral valve leaflets, which is usually thickened and distorted. It usually affects the anterior leaflet, but the cleft of posterior leaflet has also been described. Cleft mitral valve can be isolated or associated with other congenital heart anomalies.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-95465/","orphanet_url":"https://www.orpha.net/en/disease/detail/95465","names":{"fr":{"name":"Fente mitrale","definition":"Malformation cardiaque congénitale non syndromique rare caractérisée par un orifice ou un défaut ressemblant à une fente dans l'un des feuillets de la valve mitrale, généralement d'aspect épaissi et déformé. Elle affecte généralement le feuillet antérieur, mais une fente du feuillet postérieur a également été décrite. La fente mitrale peut être isolée ou associée à d'autres anomalies cardiaques congénitales."},"de":{"name":"Mitralklappenspalt","definition":"Eine seltene, angeborene, nicht-syndromale Herzfehlbildung, die durch ein schlitzförmiges Loch oder einen Defekt in einem der Mitralklappensegel gekennzeichnet ist, die in der Regel verdickt und verformt sind. Typischwerweise ist das vordere Segel betroffen, aber auch eine Spaltung des hinteren Klappensegels ist beschrieben worden. Die Mitralklappenspalte kann isoliert oder in Verbindung mit anderen angeborenen Herzanomalien auftreten."},"es":{"name":"Válvula mitral hendida","definition":"Es una malformación cardíaca congénita no sindrómica y poco frecuente caracterizada por un defecto o un orificio en forma de hendidura en una de las valvas de la válvula mitral, que por lo general está engrosada y malformada. Suele afectar a la valva anterior, aunque también se ha descrito la hendidura en la valva posterior. Puede presentarse de forma aislada o asociada a otras anomalías cardíacas congénitas."},"it":{"name":"Schisi della valvola mitrale","definition":"È una cardiopatia congenita rara non sindromica, caratterizzata da una schisi o un difetto in un lembo della valvola mitrale, che di solito è ispessito e distorto. In genere interessa il lembo anteriore, ma sono stati descritti pazienti con schisi del lembo posteriore. L'anomalia può essere isolata, oppure associarsi ad altre cardiopatie congenite."},"nl":{"name":"Gespleten mitralisklep","definition":"Een zeldzame, congenitale, niet-syndromale hartmalformatie gekarakteriseerd door een spleetvormige opening of defect in een van de klepbladen van de mitralisklep, die meestal verdikt en vervormd is. Meestal is het voorste klepblad aangetast, maar een spleet in het achterste klepblad werd ook reeds beschreven. Gespleten mitralisklep kan geïsoleerd voorkomen of geassocieerd zijn met andere congenitale hartanomalieën."},"pt":{"name":"Fenda da Válvula mitral"},"pl":{"name":"Rozszczep zastawki mitralnej"},"cs":{"name":"Rozštěp mitrální chlopně"},"uk":{"name":"Розщеплення стулки мітрального клапана","definition":"A rare, congenital, non-syndromic heart malformation characterized by a slit-like hole or defect in one of the mitral valve leaflets, which is usually thickened and distorted. It usually affects the anterior leaflet, but the cleft of posterior leaflet has also been described. Cleft mitral valve can be isolated or associated with other congenital heart anomalies."},"zh":{"name":"二尖瓣裂","definition":"一种罕见的先天性非综合征性心脏畸形，其特征是一个二尖瓣叶中有一个狭缝状的洞或缺损，该二尖瓣叶通常增厚、变形。该病通常累及二尖瓣前叶，但后叶裂也有报道。二尖瓣裂可以孤立存在，也可与其他先天性心脏异常合并存在。"},"tr":{"name":"Yarık mitral kapak"}},"xrefs":[{"source":"ICD-10","code":"Q23.3","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"ICD-11","code":"LA87.1Y","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"MONDO","code":"0019818","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0344772","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":93890,"name":"Rare developmental defect during embryogenesis"},"parents":[{"orpha":2447,"name":"Congenital mitral malformation","classifications":[147,148]}],"children":[{"orpha":95474,"name":"Double-orifice mitral valve","type":"Clinical subtype"},{"orpha":99064,"name":"Straddling and/or overriding mitral valve","type":"Clinical subtype"}],"genes":[],"genes_via_subtypes":[],"inheritance":[],"onset":[],"prevalence":[],"phenotypes":null}