{"orpha":95443,"name":"Mesocardia","type":"Morphological anomaly","group":"Disorder","status":"active","flags":[],"synonyms":["Midline heart"],"definition":"A rare, congenital non-syndromic heart malformation characterized by an atypical location of the heart in a central position within the thorax, with the apex situated in the midline. The atrial arrangement is usually normal, whereas the ventricles may be inverted. Various congenital heart anomalies have also been associated, such as congenitally corrected transposition of the great arteries.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-95443/","orphanet_url":"https://www.orpha.net/en/disease/detail/95443","names":{"fr":{"name":"Mésocardie","definition":"Malformation cardiaque congénitale non syndromique rare caractérisée par une localisation atypique du coeur en position centrale dans le thorax, l'apex étant situé sur la ligne médiane du thorax. Les oreillettes sont généralement en situs solitus, tandis que les ventricules peuvent être en situs inversus. Diverses anomalies cardiaques congénitales et un situs inversus viscéral ont également été associés."},"de":{"name":"Mesokardie","definition":"Eine seltene, angeborene, nicht-syndromale Herzfehlbildung, die durch eine atypische Lage des Herzens in zentraler Position im Thorax gekennzeichnet ist, wobei sich der Apex in der Mittellinie des Thorax befindet. Die Vorhöfe sind normalerweise situs solitus, während die Ventrikel situs inversus sein können. Verschiedene angeborene Herzanomalien und ein viszeraler Situs inversus sind ebenfalls assoziiert worden."},"es":{"name":"Mesocardia","synonyms":["Corazón en la línea media"],"definition":"Es una malformación cardíaca no sindrómica, congénita y poco frecuente, caracterizada por la localización cardíaca atípica en posición centrotorácica, con el ápex situado en la línea media del tórax. Las aurículas se suelen encontrar en situs solitus, mientras que los ventrículos se encuentran en situs inversus. También se han asociado diversas anomalías cardíacas congénitas y situs inversus visceral."},"it":{"name":"Mesocardia","synonyms":["Cuore mediano"],"definition":"Si tratta di una cardiopatia congenita rara non sindromica, caratterizzata dal posizionamento atipico del cuore, che si trova al centro del torace, con l'apice posizionato sulla linea mediana del torace. Di solito gli atri si trovano in posizione normale (situs solitus), mentre i ventricoli possono essere in posizione inversa (situs inversus). Può associarsi a diverse cardiopatie congenite e a situs inversus degli organi interni."},"nl":{"name":"Mesocardie","synonyms":["Hart in middellijn"],"definition":"Een zeldzame, congenitale, niet-syndromale hartmalformatie gekarakteriseerd door een atypische locatie van het hart in een centrale positie in de thorax, met de apex op de middellijn van de thorax. Atria zijn meestal situs solitus, terwijl de ventrikels situs inversus kunnen zijn. Verschillende congenitale hartanomalieën en viscerale situs inversus werden ook reeds geassocieerd."},"pt":{"name":"Mesocardia"},"pl":{"name":"Mezokardia","synonyms":["Serce położone pośrodkowo"]},"cs":{"name":"Mezokardie","synonyms":["Srdce ve střední čáře"]},"uk":{"name":"Мезокардія","synonyms":["Серединне серце"],"definition":"A rare, congenital non-syndromic heart malformation characterized by an atypical location of the heart in a central position in the thorax, with the apex in the midline of the thorax. Atria are usually situs solitus, whereas ventricles may be situs inversus. Various congenital heart anomalies and visceral situs inversus have also been associated."},"zh":{"name":"中位心","synonyms":["中位心"],"definition":"一种罕见的先天性非综合征性心脏畸形，其特征是心脏位于胸腔中心，心尖位于胸腔中线。心房通常是处于正常的解剖位置，而心室可能出现左右转位。还可伴其他各种先天性心脏异常和内脏左右镜面转位。"},"tr":{"name":"Mezokardi","synonyms":["Orta çizgi kalp"]}},"xrefs":[{"source":"ICD-10","code":"Q24.8","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"ICD-11","code":"LA80.2","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"1251061251"},{"source":"MONDO","code":"0019807","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0265865","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":93890,"name":"Rare developmental defect during embryogenesis"},"parents":[{"orpha":98716,"name":"Heart position anomaly","classifications":[147,148]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":[],"onset":[],"prevalence":[],"phenotypes":null}