{"orpha":95431,"name":"Twin to twin transfusion syndrome","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":["Feto-fetal transfusion syndrome"],"definition":"Twin twin transfusion syndrome (TTTS) is a rare condition seen in twin monochorionic pregnancies, typically developing during the 15-26 week gestation period and usually due to unbalanced intertwin placental anastomoses, where an unequal exchange of blood between twins causes oligohydramnios in one sac and polyhydramnios in the other which can lead to a high perinatal mortality rate and a high rate of disability in survivors if left untreated","note":null,"url":"https://raremap.alftech.space/d/ORPHA-95431/","orphanet_url":"https://www.orpha.net/en/disease/detail/95431","names":{"fr":{"name":"Syndrome de transfusion foeto-foetale","synonyms":["STT","Syndrome transfuseur-transfusé"],"definition":"Le syndrome de transfusion foeto-foetale (STT) est une rare complication spécifique des grossesses gémellaires monochoriales, survenant généralement à 15-26 semaines de la grossesse et qui est souvent due à un déséquilibre des anastomoses placentaires gémellaires, où un échange sanguin inégal entre les jumeaux provoque un oligoamnios dans une poche et un hydramnios dans l'autre, ce qui peut entraîner une mortalité périnatale ainsi qu'une situation de handicap chez les survivants s'ils ne sont pas pris en charge adéquatemment."},"de":{"name":"Zwillings-Transfusions-Syndrom","synonyms":["FFTS","Fetofetales Transfusions-Syndrom","TTTS"],"definition":"Das Zwillings-Transfusions-Syndrom (TTTS) ist eine seltene, bei monochoriaten Zwillings-Schwangerschaften auftretende Störung, die sich typisch in der 15.-26. Schwangerschaftswoche entwickelt. Ursache sind in der Regel plazentale Anastomosen mit ungleicher Verteilung des Blutes zwischen den Zwillingen. Die Folge ist ein Oligohydramnion in der einen und ein Polyhydramnion in der anderen Fruchthöhle, mit erhöhter perinataler Mortalität und einer hohen Rate von Behinderungen bei den Überlebenden, wenn diese nicht behandelt werden."},"es":{"name":"Síndrome de transfusión gemelo-gemelo","synonyms":["Síndrome de transfusión feto-fetal"],"definition":"El síndrome de transfusión gemelo-gemelo (TTTS) es una enfermedad poco frecuente observada en embarazos monocoriales, que se desarrolla típicamente en las semanas 15-26 del periodo de gestación, y que es causada generalmente por el desequilibrio en la anastomosis placentaria entre gemelos, donde un intercambio de sangre desigual entre gemelos causa oligohidramnios en un saco y polihidramnios en el otro, lo que puede dar lugar a una alta tasa de mortalidad perinatal y una alta tasa de discapacidad en los supervivientes si no es tratado."},"it":{"name":"Sindrome da trasfusione gemello-gemello","synonyms":["Sindrome della trasfusione feto-fetale"],"definition":"La sindrome da trasfusione gemello-gemello (TTTS) è una malattia rara osservata nelle gravidanze monocoriali, che si sviluppa tipicamente durante la 15-26° settimana di gestazione e, di solito, è dovuta al disequilibrio delle anastomosi placentari tra i gemelli, quando uno scambio asimmetrico di sangue tra i gemelli provoca oligoidramnios in un sacco e poliidramnios nell'altro, comportando un tasso elevato di mortalità prenatale e di disabilità nei sopravvissuti, in assenza di trattamento."},"nl":{"name":"Tweelingtransfusiesyndroom","synonyms":["Foeto-foetaal transfusiesyndroom"],"definition":"Een zeldzame aandoening, waargenomen bij zwangerschappen van monochoriale tweelingen, doorgaans optredend tijdens week 15-26 van de zwangerschap, en meestal te wijten aan ongebalanceerde anastomosen in placenta tussen tweelingen, waarbij ongelijke uitwisseling van bloed tussen tweelingen leidt tot oligohydramnion in één zak en polyhydramnion in de andere, wat kan resulteren in hoge perinatale mortaliteit en hoog percentage van invaliditeit bij overlevenden zonder behandeling."},"pt":{"name":"Síndrome de transfusão de gémeo-para-gémeo"},"pl":{"name":"Zespół transfuzji międzypłodowej","synonyms":["Zespół przetoczenia krwi między płodami"]},"cs":{"name":"Syndrom feto-fetální transfuze","synonyms":["Feto-fetální transfuzní syndrom"]},"uk":{"name":"Синдром трансфузії від близнюка до близнюка","synonyms":["Фето-фетальний трансфузійний синдром"],"definition":"Twin twin transfusion syndrome (TTTS) is a rare condition seen in twin monochorionic pregnancies, typically developing during the 15-26 week gestation period and usually due to unbalanced intertwin placental anastomoses, where an unequal exchange of blood between twins causes oligohydramnios in one sac and polyhydramnios in the other which can lead to a high perinatal mortality rate and a high rate of disability in survivors if left untreated"},"zh":{"name":"双胎输血综合征","synonyms":["双胎输血综合征"],"definition":"双胎输血综合征（TTTS）是一种见于双胎单绒毛膜妊娠情况下的罕见疾病，通常发生在妊娠期15-26周，通常是由于不平衡的双胎间胎盘吻合，形成双胎之间不平等的血液交换，导致一个囊内羊水过少，而另一个囊中羊水过多，如果不治疗，可能导致围产期高死亡率和幸存者高致残率。"},"tr":{"name":"İkizden ikize transfüzyon sendromu","synonyms":["Feto-fetal transfüzyon sendromu"]}},"xrefs":[{"source":"ICD-10","code":"O43.0","qualifier":"NTBT","icd_relation":"inclusion","validated":true},{"source":"ICD-10","code":"P02.3","qualifier":"NTBT","icd_relation":"index","validated":true},{"source":"ICD-11","code":"JA8A.0","qualifier":"NTBT","icd_relation":"index","validated":true,"icd11_uri":"850604370"},{"source":"MONDO","code":"0019805","qualifier":"E","icd_relation":null,"validated":true},{"source":"MeSH","code":"D005330","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C2909036","qualifier":"E","icd_relation":null,"validated":true},{"source":"GARD","code":"325","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10058328","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":96344,"name":"Rare gynecologic or obstetric disease"},"parents":[{"orpha":617310,"name":"Rare disorder due to unbalanced inter-twin blood transfusion","classifications":[205]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":[],"onset":[],"prevalence":[],"phenotypes":null}