{"orpha":94059,"name":"Uremic pruritus","type":"Particular clinical situation in a disease or syndrome","group":"Disorder","status":"active","flags":[],"synonyms":[],"definition":null,"note":null,"url":"https://raremap.alftech.space/d/ORPHA-94059/","orphanet_url":"https://www.orpha.net/en/disease/detail/94059","names":{"fr":{"name":"Prurit urémique"},"de":{"name":"Pruritus, urämischer"},"es":{"name":"Prurito urémico"},"it":{"name":"Prurito uremico"},"nl":{"name":"Uremische pruritus"},"pt":{"name":"Prurido urémico"},"pl":{"name":"Świąd mocznicowy"},"cs":{"name":"Uremický pruritus"},"uk":{"name":"Уремічний свербіж"},"zh":{"name":"尿毒症性皮肤瘙痒症"},"tr":{"name":"Üremik kaşıntı"}},"xrefs":[{"source":"ICD-10","code":"L29.8","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"ICD-11","code":"EC90.10","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"1928505945"},{"source":"UMLS","code":"C1262019","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10060875","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":97992,"name":"Rare hematologic disease"},"parents":[{"orpha":90077,"name":"Other acquired skin disease","classifications":[187]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["Adolescent","Adult","Childhood","Elderly"],"prevalence":[{"type":"Point prevalence","qualification":"Value and class","class":"1-5 / 10 000","value":35.0,"area":"Europe","status":"Validated","source":"European Medicines Agency 2010[OTHER]"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2020-03-17","source":"24402092[PMID]_29183013[PMID]_9585892[PMID]","terms":[{"hpo":"HP:0012622","label":"Chronic kidney disease","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0000958","label":"Dry skin","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0003138","label":"Increased blood urea nitrogen","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0000989","label":"Pruritus","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0011112","label":"Abnormality of serum cytokine level","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0011354","label":"Generalized abnormality of skin","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0031901","label":"Increased serum mast cell beta-tryptase concentration","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0031355","label":"Maintenance insomnia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002360","label":"Sleep abnormality","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0003774","label":"Stage 5 chronic kidney disease","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000716","label":"Depression","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0003072","label":"Hypercalcemia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002918","label":"Hypermagnesemia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0011123","label":"Inflammatory abnormality of the skin","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0100725","label":"Lichenification","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0200034","label":"Papule","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001581","label":"Recurrent skin infections","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0008732","label":"Renal hypophosphatemia","frequency":"Occasional (29-5%)","criteria":null}]}}