{"orpha":93555,"name":"Mixed cryoglobulinemia type III","type":"Etiological subtype","group":"Subtype of disorder","status":"active","flags":[],"synonyms":["MC type III"],"definition":"A clinico-serological subtype of mixed cryoglobulinemia syndrome, is an immune complex disorder, characterized by purpura, weakness and arthralgia and defined immunochemically by cryoglobulins containing both polyclonal IgGs and polyclonal IgMs.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-93555/","orphanet_url":"https://www.orpha.net/en/disease/detail/93555","names":{"fr":{"name":"Cryoglobulinémie mixte type III","synonyms":["MC type III"],"definition":"Sous-type clinico-sérologique du syndrome de cryoglobulinémie mixte, une maladie à complexes immuns caractérisé par un purpura, une faiblesse et une arthralgie et défini sur le plan immunochimique par des cryoglobulines contenant à la fois des IgG polyclonales et des IgM polyclonales."},"de":{"name":"Kryoglobulinämie, gemischte, Typ III","synonyms":["MC vom Typ II I"],"definition":"Ein klinisch-serologischer Subtyp des gemischten Kryoglobulinämie-Syndroms, einer Immunkomplexerkrankung, die durch Purpura, Schwäche und Arthralgie gekennzeichnet ist und immunchemisch durch Kryoglobuline definiert ist, die sowohl polyklonale IgGs als auch polyklonale IgMs enthalten."},"es":{"name":"Crioglobulinemia mixta tipo III","synonyms":["Crioglobulinemia mixta tipo 3"],"definition":"Es un subtipo clínico-serológico del síndrome de crioglobulinemia mixta, es un trastorno inmuno-complejo caracterizado por púrpura, debilidad y artralgia, y definido inmunoquímicamente por crioglobulinas compuestas por IgG e IgM policlonales."},"it":{"name":"Crioglobulinemia mista, tipo III","synonyms":["MC, tipo III"],"definition":"La crioglobulinemia mista tipo III, sottotipo clinico sierologico della crioglobulinemia mista (CM, si veda questo termine), è una patologia da formazione di immuno-complessi, caratterizzata da porpora, debolezza e artralgia. È definita immunochimicamente dalle crioglobuline contenenti sia IgG che IgM policlonali."},"nl":{"name":"Gemengde cryoglobulinemie type III","synonyms":["MC type III"],"definition":"Een klinisch-serologisch subtype van gemengde cryoglobulinemie-syndroom, een aandoening van immuuncomplex, gekarakteriseerd door purpura, zwakte en artralgie, en immunochemisch gedefinieerd door cryoglobulinen bestaande uit zowel polyklonaal IgG als polyklonaal IgM."},"pt":{"name":"Crioglobulinemia mista tipo III","definition":"A crioglobulinemia mista tipo III, um subtipo serologico-clínico de crioglobulinemia mista (CM, ver este termo), é uma doença de complexos imunes, caracterizada por púrpura, fraqueza e artralgia e imunoquimicamente definida por crioglobulinas que contenham tanto IgGs como IgMs policlonais."},"pl":{"name":"Mieszana krioglobulinemia typu III","synonyms":["MC type III"]},"cs":{"name":"Smíšená kryoglobulinemie, typ III","synonyms":["MC typ III"]},"uk":{"name":"Змішана кріоглобулінемія, тип III","synonyms":["MC тип III"],"definition":"A clinico-serological subtype of mixed cryoglobulinemia syndrome, is an immune complex disorder, characterized by purpura, weakness and arthralgia and defined immunochemically by cryoglobulins containing both polyclonal IgGs and polyclonal IgMs."},"zh":{"name":"混合性冷沉球蛋白血症III型","synonyms":["MC III型"],"definition":"混合性冷沉球蛋白血症Ⅲ型，混合性冷沉球蛋白血症（MC，见该词条）的一种较少见的临床血清学亚型，是一种以紫癜、虚弱和关节痛为特征的免疫复合物疾病，免疫化学特征为多克隆IgGs（自身抗原）和多克隆IgM（自身抗体）组成的冷球蛋白。"},"tr":{"name":"Karma kriyoglobulinemi tip III","synonyms":["MC tip III"]}},"xrefs":[{"source":"ICD-10","code":"D89.1","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"ICD-11","code":"4A44.90","qualifier":"NTBT","icd_relation":"attributed","validated":true,"icd11_uri":"null"},{"source":"MONDO","code":"0019727","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C5680263","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":98023,"name":"Rare systemic or rheumatologic disease"},"parents":[{"orpha":91138,"name":"Cryoglobulinemic vasculitis","classifications":[181,184,188,196,198,231,233]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":[],"onset":["All ages"],"prevalence":[{"type":"Point prevalence","qualification":"Class only","class":"Unknown","value":0.0,"area":"Worldwide","status":"Not yet validated","source":"ORPHANET"}],"phenotypes":null}