{"orpha":93554,"name":"Mixed cryoglobulinemia type II","type":"Etiological subtype","group":"Subtype of disorder","status":"active","flags":[],"synonyms":["MC type II"],"definition":"A clinico-serological subtype of mixed cryoglobulinemia syndrome, an immune complex disorder, characterized by purpura, weakness and arthralgia and defined immunochemically by cryoglobulins composed of polyclonal IgGs (autoantigens) and monoclonal IgM (autoantibody).","note":null,"url":"https://raremap.alftech.space/d/ORPHA-93554/","orphanet_url":"https://www.orpha.net/en/disease/detail/93554","names":{"fr":{"name":"Cryoglobulinémie mixte type II","synonyms":["MC type II"],"definition":"Sous-type clinico-sérologique du syndrome de cryoglobulinémie mixte, une maladie à complexes immuns, caractérisé par un purpura, une faiblesse et une arthralgie et défini sur le plan immunochimique par des cryoglobulines composées d'IgG polyclonales (auto-antigènes) et d'IgM monoclonales (auto-anticorps)."},"de":{"name":"Kryoglobulinämie, gemischte, Typ II","synonyms":["MC vom Typ II"],"definition":"Ein klinisch-serologischer Subtyp des gemischten Kryoglobulinämie-Syndroms, einer Immunkomplexerkrankung, die durch Purpura, Schwäche und Arthralgie gekennzeichnet ist und immunchemisch durch Kryoglobuline aus polyklonalen IgGs (Autoantigenen) und monoklonalen IgM (Autoantikörpern) definiert ist."},"es":{"name":"Crioglobulinemia mixta tipo II","definition":"Es un subtipo clínico-serológico del síndrome de crioglobulinemia mixta, es un trastorno inmuno-complejo caracterizado por púrpura, debilidad y artralgia, y definido inmunoquímicamente por crioglobulinas compuestas por IgG policlonales (autoantígenos) e IgM monoclonal (autoanticuerpo)."},"it":{"name":"Crioglobulinemia mista, tipo II","synonyms":["MC, tipo II"],"definition":"La crioglobulinemia mista tipo II, sottotipo clinico-sierologico della crioglobulinemia mista (si veda questo termine), è una patologia associata alla formazione di immuno-complessi, caratterizzata da porpora, debolezza ed artralgia. È definita immunochimicamente dalla presenza di crioglobuline composte da IgG policlonali (autoantigeni) e IgM monoclonali (autoanticorpi)."},"nl":{"name":"Gemengde cryoglobulinemie type II","synonyms":["MC type II"],"definition":"Een klinisch-serologisch subtype van gemengde cryoglobulinemie-syndroom, een aandoening van immuuncomplex, gekarakteriseerd door purpura, zwakte en artralgie, en immunochemisch gedefinieerd door cryoglobulinen bestaande uit polyklonaal IgG (auto-antigenen) en monoklonaal IgM (auto-antilichaam)."},"pt":{"name":"Crioglobulinemia mista tipo II","definition":"A crioglobulinemia mista tipo II, um subtipo serologico-clínico de crioglobulinemia mista (CM, ver este termo), é uma doença de complexos-imunes, caracterizada por púrpura, fraqueza e artralgia e definida imunoquimicamente por crioglobulinas compostas de IgGs policlonais (auto-antigénios) e IgM monoclonal (auto-anticorpo)."},"pl":{"name":"Mieszana krioglobulinemia typu II","synonyms":["MC type II"]},"cs":{"name":"Smíšená kryoglobulinemie, typ II","synonyms":["MC typ II"]},"uk":{"name":"Змішана кріоглобулінемія, тип II","synonyms":["MC тип II"],"definition":"A clinico-serological subtype of mixed cryoglobulinemia syndrome, an immune complex disorder, characterized by purpura, weakness and arthralgia and defined immunochemically by cryoglobulins composed of polyclonal IgGs (autoantigens) and monoclonal IgM (autoantibody)."},"zh":{"name":"II型混合性冷沉球蛋白血症","synonyms":["MC II型"],"definition":"混合性冷沉球蛋白血症Ⅱ型，混合性冷沉球蛋白血症（MC，见该词条）的一种较少见的临床血清学亚型，是一种以紫癜、虚弱和关节痛为特征的免疫复合物疾病，免疫化学特征为多克隆IgGs（自身抗原）和单克隆IgM（自身抗体）组成的冷球蛋白。"},"tr":{"name":"Tip II karma kriyoglobulinemi","synonyms":["MC tip II"]}},"xrefs":[{"source":"ICD-10","code":"D89.1","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"ICD-11","code":"4A44.90","qualifier":"NTBT","icd_relation":"attributed","validated":true,"icd11_uri":"null"},{"source":"MONDO","code":"0019726","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C5680264","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":98023,"name":"Rare systemic or rheumatologic disease"},"parents":[{"orpha":91138,"name":"Cryoglobulinemic vasculitis","classifications":[181,184,188,196,198,231,233]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":[],"onset":["All ages"],"prevalence":[{"type":"Point prevalence","qualification":"Class only","class":"Unknown","value":0.0,"area":"Worldwide","status":"Not yet validated","source":"ORPHANET"}],"phenotypes":null}