{"orpha":91547,"name":"Relapsing fever","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":[],"definition":"An infectious disease, rare in Europe, characterized by relapsing fever accompanied by headaches, vomiting and myalgia lasting 2-7&nbsp;days, with afebrile intervals of up to 10&nbsp;days. It is caused by bacterial species of the genus <i>Borrelia</i>, and transmitted by ticks (tick-borne relapsing fever; TBRF) and lice (louse-borne relapsing fever; LBRF).","note":null,"url":"https://raremap.alftech.space/d/ORPHA-91547/","orphanet_url":"https://www.orpha.net/en/disease/detail/91547","names":{"fr":{"name":"Fièvre récurrente infectieuse","definition":"Maladie infectieuse, rare en Europe, caractérisée par l'alternance d'accès fébriles récurrents accompagnés de maux de tête, de vomissements et de myalgies persistant entre 2 à 7&nbsp;jours, et d'intervalles sans fièvre pouvant aller jusqu'à 10&nbsp;jours. Elle est causée par des espèces bactériennes du genre <i>Borrelia</i> et transmise par des tiques (fièvre récurrente à tiques) et des poux (fièvre récurrente à poux)."},"de":{"name":"Rückfallfieber","definition":"Es handelt sich um eine in Europa seltene Infektionskrankheit, die durch rezidivierendes Fieber, begleitet von Kopfschmerzen, Erbrechen und Myalgie, gekennzeichnet ist und zwei bis sieben Tage andauert, mit afebrilen Intervallen von bis zu zehn Tagen. Sie wird durch Bakterien der Gattung <i>Borrelia</i> verursacht und durch Zecken (Zecken-Rückfallfieber, TBRF) oder Läuse (Läuse-Rückfallfieber, LBRF) übertragen."},"es":{"name":"Fiebre recurrente","definition":"Es una enfermedad infecciosa, poco frecuente en Europa, caracterizada por fiebre recurrente acompañada de cefaleas, vómitos y mialgias de 2 a 7 días de duración, con intervalos afebriles de hasta 10 días. Está causada por especies bacterianas del género <i>Borrelia</i> y transmitida por garrapatas (fiebre recurrente transmitida por garrapatas; FRTG) y por piojos (fiebre recurrente transmitida por piojo; FRTP)."},"it":{"name":"Febbre ricorrente"},"nl":{"name":"Terugkerende koorts","synonyms":["Febris recurrens"],"definition":"Een infectieuze aandoening, zeldzaam in Europa, gekenmerkt door recidiverende koorts vergezeld van hoofdpijn, braken en myalgie gedurende 2-7 dagen, met afebriele intervallen van tot wel 10 dagen. Het wordt veroorzaakt door een bacteriesoort van het geslacht <i>Borrelia</i>, en overgedragen door teken (door teken overgedragen recidiverende koorts; TBRF) en luizen (door luizen overgedragen recidiverende koorts; LBRF)."},"pt":{"name":"Febre recorrente","definition":"A febre recorrente é uma infeção causada por bactérias do género <i>Borrelia</i>, excluindo a possibilidade da doença de Lyme (ver este termo) pertencente ao complexo <i>Borrelia burgdorferi</i>."},"pl":{"name":"Dur powrotny","definition":"Choroba zakaźna, rzadka w Europie, charakteryzująca się nawracającą gorączką z towarzyszącymi bólami głowy, wymiotami i bólami mięśni trwającymi od 2 do 7 dni, z przerwami bezgorączkowymi trwającymi do 10 dni. Wywołują ją gatunki bakterii z rodzaju Borrelia, a przenoszona jest przez kleszcze lub wszy."},"cs":{"name":"Návratná horečka"},"uk":{"name":"Рецидивуюча лихоманка","definition":"Relapsing fever is an infection caused by bacteria of the genus <i>Borrelia</i>, excluding those responsible for Lyme disease (see this term) belonging to the <i>Borrelia burgdorferi</i> complex."},"zh":{"name":"回归热","definition":"复发热是一种由 Borrelia属细菌引起的感染，不包括那些引起莱姆病（见该词条）的细菌——属于 Borrelia burgdorferi 集群。"},"tr":{"name":"Tekrarlayan ateş"}},"xrefs":[{"source":"ICD-10","code":"A68.0","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"A68.1","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"A68.9","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-11","code":"1C1J","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"965498095"},{"source":"MONDO","code":"0019633","qualifier":"E","icd_relation":null,"validated":true},{"source":"MeSH","code":"D012061","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0035021","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10038300","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":68416,"name":"Rare infectious disease"},"parents":[{"orpha":163582,"name":"Rare bacterial infectious disease","classifications":[203]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["All ages"],"prevalence":[{"type":"Point prevalence","qualification":"Class only","class":"Unknown","value":0.0,"area":"Worldwide","status":"Not yet validated","source":"ORPHANET"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2019-10-25","source":"31187963[PMID]_29016302[PMID]","terms":[{"hpo":"HP:0011227","label":"Elevated circulating C-reactive protein concentration","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0001945","label":"Fever","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0003573","label":"Increased total bilirubin","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0001873","label":"Thrombocytopenia","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0001903","label":"Anemia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002910","label":"Elevated circulating hepatic transaminase concentration","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002315","label":"Headache","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0025435","label":"Increased circulating lactate dehydrogenase concentration","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001974","label":"Increased total leukocyte count","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000952","label":"Jaundice","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0003326","label":"Myalgia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002027","label":"Abdominal pain","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001892","label":"Abnormal bleeding","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000079","label":"Abnormality of the urinary system","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001919","label":"Acute kidney injury","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002829","label":"Arthralgia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0025143","label":"Chills","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0012735","label":"Cough","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0003259","label":"Elevated circulating creatinine concentration","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0012378","label":"Fatigue","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002615","label":"Hypotension","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001882","label":"Leukopenia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0031179","label":"Nuchal rigidity","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001649","label":"Tachycardia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002013","label":"Vomiting","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002014","label":"Diarrhea","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0000421","label":"Epistaxis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0000790","label":"Hematuria","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0002105","label":"Hemoptysis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0011899","label":"Hyperfibrinogenemia","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0011897","label":"Neutrophilia","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0008151","label":"Prolonged prothrombin time","frequency":"Very rare (<4-1%)","criteria":null}]}}