{"orpha":91546,"name":"Lyme disease","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":["Lyme borreliosis"],"definition":"Lyme disease (named after the towns in the USA where the disease was first identified) is a bacterial infection caused by <i>Borrelia burgdorferi</i>.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-91546/","orphanet_url":"https://www.orpha.net/en/disease/detail/91546","names":{"fr":{"name":"Maladie de Lyme","synonyms":["Borréliose de Lyme"],"definition":"La maladie de Lyme (du nom du lieu où la maladie a été identifiée aux USA) est une infection bactérienne due à <i>Borrelia burgdorferi</i>."},"de":{"name":"Lyme-Krankheit","synonyms":["Lyme-Borreliose"],"definition":"Die Lyme-Borreliose (benannt nach den Städten in den USA, in denen die Krankheit zuerst identifiziert wurde) ist eine bakterielle Infektion, die durch <i>Borrelia burgdorferi</i> verursacht wird."},"es":{"name":"Fiebre de Lyme","synonyms":["Borreliosis de Lyme"],"definition":"La enfermedad de Lyme (llamada así por la ciudad de los EE. UU. donde se identificó la enfermedad por primera vez) es una infección bacteriana causada por <i>Borrelia burgdorferi</i>."},"it":{"name":"Malattia di Lyme","synonyms":["Borreliosi di Lyme"]},"nl":{"name":"Ziekte van Lyme","synonyms":["Lyme-borreliose"],"definition":"Ziekte van Lyme (genoemd naar de steden in de VSA waar de ziekte voor het eerst werd geïdentificeerd) is een bacteriële infectie veroorzaakt door <i>Borrelia burgdorferi</i>."},"pt":{"name":"Doença de Lyme","definition":"A doença de Lyme (segundo a cidades dos EUA onde a doença foi inicialmente identificada) é uma infeção bacteriana causada por <i>Borrelia burgdorferi</i>."},"pl":{"name":"Choroba z Lyme","synonyms":["Borelioza z Lyme"]},"cs":{"name":"Lymeská nemoc","synonyms":["Lymeská borelióza"]},"uk":{"name":"Хвороба Лайма","synonyms":["Лайм-бореліоз"],"definition":"Lyme disease (named after the towns in the USA where the disease was first identified) is a bacterial infection caused by <i>Borrelia burgdorferi</i>."},"zh":{"name":"莱姆病","synonyms":["兰姆氏包柔螺旋体病"],"definition":"莱姆病（以首次发现该病的美国城镇命名）是一种由Borrelia burgdorferi引起的细菌感染。"},"tr":{"name":"Lyme hastalığı","synonyms":["Lyme borelyozu"]}},"xrefs":[{"source":"ICD-10","code":"A69.2","qualifier":"E","icd_relation":"specific","validated":true},{"source":"ICD-11","code":"1C1G","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"1600014919"},{"source":"MONDO","code":"0019632","qualifier":"E","icd_relation":null,"validated":true},{"source":"MeSH","code":"D008193","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0024198","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10025169","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":68416,"name":"Rare infectious disease"},"parents":[{"orpha":206613,"name":"Infectious disease with peripheral neuropathy","classifications":[181]},{"orpha":163582,"name":"Rare bacterial infectious disease","classifications":[203]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["All ages"],"prevalence":[{"type":"Annual incidence","qualification":"Value and class","class":">1 / 1000","value":177.5,"area":"Europe","status":"Validated","source":"[EXPERT]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-5 / 10 000","value":16.6,"area":"France","status":"Validated","source":"[EXPERT]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-5 / 10 000","value":21.9,"area":"Worldwide","status":"Not yet validated","source":"emedicine[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-5 / 10 000","value":12.37,"area":"Hungary","status":"Validated","source":"23428090[PMID]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-5 / 10 000","value":36.0,"area":"Sweden","status":"Not yet validated","source":"ORPHANET"},{"type":"Annual incidence","qualification":"Value and class","class":">1 / 1000","value":100.0,"area":"United States","status":"Validated","source":"24045727[PMID]"},{"type":"Point prevalence","qualification":"Class only","class":"Unknown","value":0.0,"area":"Europe","status":"Not yet validated","source":"ORPHANET"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2016-06-01","source":null,"terms":[{"hpo":"HP:0001369","label":"Arthritis","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0006824","label":"Cranial nerve paralysis","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001386","label":"Joint swelling","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001287","label":"Meningitis","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0100576","label":"Amaurosis fugax","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0011675","label":"Arrhythmia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002829","label":"Arthralgia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001678","label":"Atrioventricular block","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000708","label":"Atypical behavior","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0004334","label":"Dermal atrophy","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0012378","label":"Fatigue","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001945","label":"Fever","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002315","label":"Headache","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002383","label":"Infectious encephalitis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0100785","label":"Insomnia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002354","label":"Memory impairment","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001324","label":"Muscle weakness","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0003326","label":"Myalgia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002017","label":"Nausea and vomiting","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0003401","label":"Paresthesia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0009830","label":"Peripheral neuropathy","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000613","label":"Photophobia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0200036","label":"Skin nodule","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000554","label":"Uveitis","frequency":"Occasional (29-5%)","criteria":null}]}}