{"orpha":90160,"name":"Pressure-induced localized lipoatrophy","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":["Lipoatrophia semicircularis","Semicircular lipoatrophy"],"definition":"Pressure-induced localized lipoatrophy is a rare, acquired, localized lipodystrophy characterized by band-like, horizontal, asymptomatic, lipoatrophic depressions with clinically normal overlying skin usually involving the anterolateral aspect of the thighs. An identifiable history of the repeated mechanical microtrauma due to occupational or postural habits is present.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-90160/","orphanet_url":"https://www.orpha.net/en/disease/detail/90160","names":{"fr":{"name":"Lipoatrophie localisée due à la pression","synonyms":["Lipoatrophie semi-circulaire"],"definition":"Une lipoatrophie localisée, acquise et rare, caractérisée par des dépressions lipoatrophiques asymptomatiques, horizontales et en forme de bande, affectant généralement la face antérolatérale des cuisses. La peau recouvrant les dépressions est cliniquement normale. Les patients présentent des antécédents identifiables de microtraumatismes mécaniques répétés, dus à des habitudes posturales ou professionnelles."},"de":{"name":"Lipoatrophie, lokale, druck-induzierte","synonyms":["Lipoatrophia semicircularis"],"definition":"Bei der druckinduzierten lokalisierten Lipoatrophie handelt es sich um eine seltene, erworbene, lokalisierte Lipodystrophie, die durch bandförmige, horizontale, asymptomatische, lipoatrophische Vertiefungen mit klinisch normaler darüberliegender Haut gekennzeichnet ist und meist den anterolateralen Aspekt der Oberschenkel betrifft. Es liegt eine identifizierbare Vorgeschichte des wiederholten mechanischen Mikrotraumas aufgrund beruflicher oder haltungsbedingter Gewohnheiten vor."},"es":{"name":"Lipoatrofia localizada inducida por presión","synonyms":["Lipoatrofia semicircular","Lipoatrophia semicircularis"],"definition":"Es una lipodistrofia localizada, adquirida y poco frecuente, caracterizada por depresiones lipoatróficas horizontales, asintomáticas, en banda, con una piel suprayacente clínicamente normal que, por lo general, se localiza en la cara anterolateral de los muslos. Se asocia a una historia previa de microtraumatismos mecánicos repetidos de origen ocupacional o postural."},"it":{"name":"Lipoatrofia localizzata indotta dalla pressione","definition":"La lipoatrofia localizzata indotta dalla pressione è una lipodistrofia localizzata acquisita rara, caratterizzata da depressioni lipoatrofiche asintomatiche orizzontali a banda, rivestite da cute clinicamente normale, di solito localizzate nella porzione anterolaterale delle cosce. L'anamnesi remota è positiva per microtraumi meccanici ripetuti causati da abitudini professionali o posturali."},"nl":{"name":"Drukgeïnduceerde gelokaliseerde lipoatrofie","synonyms":["Lipoatrophia semicircularis","Semicirculaire lipoatrofie"],"definition":"Drukgeïnduceerde gelokaliseerde lipoatrofie is een zeldzame, verworven, gelokaliseerde lipodystrofie die gekarakteriseerd wordt door bandachtige, horizontale, asymptomatische, lipoatrofische instulpingen met klinisch normale bovenliggende huid, meestal aan de anterolaterale delen van de dijen. Er is een identificeerbare voorgeschiedenis aanwezig van herhaalde mechanische microtrauma's als gevolg van beroepsmatige gewoonten of lichaamshoudingen."},"pt":{"name":"Lipodistrofia localizada induzida por pressão"},"pl":{"name":"Lipoatrofia zlokalizowana spowodowana uciskiem","synonyms":["Lipoatrophia semicircularis","Semicircular lipoatrophy"]},"cs":{"name":"Lokalizovaná lipoatrofie vyvolaná tlakem","synonyms":["Lipoatrophia semicircularis","Semicircular lipoatrophy"]},"uk":{"name":"Індукована тиском локальна ліпоатрофія","synonyms":["Ліпоатрофія напівкругла","Напівкругова ліпоатрофія"],"definition":"Pressure-induced localized lipoatrophy is a rare, acquired, localized lipodystrophy characterized by band-like, horizontal, asymptomatic, lipoatrophic depressions with clinically normal overlying skin usually involving the anterolateral aspect of the thighs. An identifiable history of the repeated mechanical microtrauma due to occupational or postural habits is present."},"zh":{"name":"压力诱导局限性脂质营养不良","synonyms":["半环形脂肪萎缩"]},"tr":{"name":"Basınca bağlı lokalize lipoatrofi","synonyms":["Semisirküler lipoatrofi","Lipoatrofi semisirkülaris"]}},"xrefs":[{"source":"ICD-10","code":"E88.1","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"ICD-11","code":"EF01.1","qualifier":"NTBT","icd_relation":"index","validated":true,"icd11_uri":"528253911"},{"source":"MONDO","code":"0019556","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C1260961","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":89826,"name":"Rare skin disease"},"parents":[{"orpha":79088,"name":"Localized lipodystrophy","classifications":[187,193]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":[],"onset":["Adult","Elderly"],"prevalence":[],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2017-04-19","source":"2279347[PMID]_18501172[PMID]_21865368[PMID]","terms":[{"hpo":"HP:0100578","label":"Lipoatrophy","frequency":"Obligate (100%)","criteria":null},{"hpo":"HP:0003758","label":"Reduced subcutaneous adipose tissue","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0011356","label":"Regional abnormality of skin","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0007485","label":"Absence of subcutaneous fat","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0010783","label":"Erythema","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0011123","label":"Inflammatory abnormality of the skin","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0200036","label":"Skin nodule","frequency":"Frequent (79-30%)","criteria":null}]}}